Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents

Kuo, S. C.; Lee, F. Y.; Teng, C. M. EP. Patent 667,345, 1995. Kuo, S. C.; Lee, F. Y.; Teng, C. M. US. Patent 5,574,168, 1996. Kuo, S. C.; Lee, F. Y.; Teng, C. M. Ch.P. Patent 300,893, 1997. Kuo, S. C.; Lee, F. Y.; Teng, C. M. JP. Patent 2,928,079, 1999. Lee, 2001, J. Med. Chem., 44, 3746, 10.1021/jm010001h Ko, 1994, Blood, 84, 4226, 10.1182/blood.V84.12.4226.bloodjournal84124226 Wu, 1995, Br. J. Pharmacol., 116, 1973, 10.1111/j.1476-5381.1995.tb16400.x Teng, 1997, Eur. J. Pharmacol., 320, 161, 10.1016/S0014-2999(96)00911-9 Friebe, 1996, Eur. Mol. Biol. Org. J., 15, 6863, 10.1002/j.1460-2075.1996.tb01078.x Friebe, 1998, Mol. Pharmacol., 54, 962, 10.1124/mol.54.6.962 Stasch, 2001, Nature, 410, 212, 10.1038/35065611 Wang, 2005, J. Pharmacol. Exp. Ther., 312, 917, 10.1124/jpet.104.077230 Wu, S. Y.; Pan, S. L.; Guh, J. H.; Huang, D. Y.; Chang, Y. L.; Kuo, S. C.; Lee, F. Y.; Teng, C. M. YC-1 induces apoptosis of human renal carcinoma A498 cells through activating JNK pathway. Unpublished data. Huang, 2005, Mol. Cancer Ther., 4, 1628, 10.1158/1535-7163.MCT-05-0090 Hsu, 2003, Biochem. Pharmacol., 66, 263, 10.1016/S0006-2952(03)00244-2 Pan, 2005, J. Pharmacol. Exp. Ther., 314, 35, 10.1124/jpet.105.085126 Pan, 2005, Thromb. Haemost., 93, 940, 10.1160/TH04-03-0195 Liu, 2006, J. Pharmacol. Exp. Ther., 316, 35, 10.1124/jpet.105.090563 Chun, J.G.; Yang, J. S.; Hung, L. J.; Lee, F.Y.; Teng, C. M.; Tai, S.C.; Lin, K.L.; Wang, S. F.; Kuo, S. C. Proteomics 2006 (unpublished). Chini, 1986, Boll./Ist. Sieroter. Milan., 65, 523 Otake, 2005, Mol. Pharmacol., 67, 319, 10.1124/mol.104.006080 Nakashima, 2005, J. Exp. Clin. Cancer Res., 24, 447 Wang, 1997, Int. J. Cancer, 70, 699, 10.1002/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5 Bradford, 1976, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3