Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients

P.F. Chinnery, Gene Reviews (2005), available at (www.genetests.org) searching for ‘neuroferritinopathy’. Curtis, 2001, Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease, Nat. Genet., 28, 350, 10.1038/ng571 Chinnery, 2003, Neuroferritinopathy in a French family with late onset dominant dystonia, J. Med. Genet., 40, e69, 10.1136/jmg.40.5.e69 Zhao, 2003, Multiple pathways for mineral core formation in mammalian apoferritin. The role of hydrogen peroxide, Biochemistry, 42, 3142, 10.1021/bi027357v Schafer, 2000, Iron and free radical oxidations in cell membranes, Cell. Mol. Biol., 46, 657 Kirschvink, 1992, Magnetite biomineralization in the human brain, Proc. Natl. Acad. Sci. U. S. A., 89, 7683, 10.1073/pnas.89.16.7683 Goodman, 1953, Alzheimer's disease—A clinicopathologic analysis of 23 cases with a theory on pathogenesis, J. Nerv. Ment. Dis., 118, 97, 10.1097/00005053-195308000-00001 Kienzl, 1999, Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease?, Life Sci., 65, 1973, 10.1016/S0024-3205(99)00458-0 Bush, 2000, Metals and neuroscience, Curr. Opin. Chem. Biol., 4, 184, 10.1016/S1367-5931(99)00073-3 Lynch, 2000, Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions, Exp. Gerontol., 35, 445, 10.1016/S0531-5565(00)00112-1 Ke, 2003, Oxidative stress is associated with intermittent hypoxia-mediated apoptosis in cortical neuronal cells, Free Radic. Biol. Med., 35, S158 Ke, 2003, Iron misregulation in the brain: a primary cause of neurodegenerative disorders, Lancet Neurol., 2, 246, 10.1016/S1474-4422(03)00353-3 Hautot, 2003, Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue, Proc. R. Soc. Lond., B, 270, S62, 10.1098/rsbl.2003.0012 Collingwood, 2005, In situ characterization and mapping of iron compounds in Alzheimer's disease tissue, J. Alzheimer's Dis., 7, 267, 10.3233/JAD-2005-7401 Gossuin, 2005, Looking for biogenic magnetite in brain ferritin using NMR relaxometry, NMR Biomed., 18, 469, 10.1002/nbm.983 Smith, 1997, Iron accumulation in Alzheimer's disease is a source of redox-generated free radicals, Proc. Natl. Acad. Sci. U. S. A., 94, 9866, 10.1073/pnas.94.18.9866 Sayre, 2000, In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals, J. Neurochem., 74, 270, 10.1046/j.1471-4159.2000.0740270.x Quintana, 2000, Initial studies with high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brains of patients with progressive supranuclear palsy and Alzheimer disease, Cell. Mol. Biol., 46, 807 Quintana, 2004, Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin, J. Struct. Biol., 147, 166, 10.1016/j.jsb.2004.03.001 Hautot, 2005, Superconducting quantum interference device measurements of dilute magnetic materials in biological samples, Rev. Sci. Instrum., 76, 45101, 10.1063/1.1868272 Dobson, 2001, Nanoscale biogenic iron oxides and neurodegenerative disease, FEBS Lett., 496, 1, 10.1016/S0014-5793(01)02386-9 Dobson, 2004, Magnetic iron compounds in neurological disorders, Ann. N. Y. Acad. Sci., 1012, 183, 10.1196/annals.1306.016 Dobson, 1996, magnetic properties of human hippocampal tissue—Evaluation of artefact and contamination sources, Brain Res. Bull., 39, 255, 10.1016/0361-9230(95)02132-9 Dubiel, 1999, Magnetic properties of human liver and brain ferritin, Eur. Biophys. J., 28, 263, 10.1007/s002490050208 Makhlouf, 1997, Magnetic hysteresis anomalies in ferritin, Phys. Rev. B, 55, 717, 10.1103/PhysRevB.55.R14717 Gilles, 2000, Non-Langevin behaviour of the uncompensated magnetization in nanoparticles of artificial ferritin, Eur. Phys. J., B, 17, 417, 10.1007/s100510070121 J. Collingwood, J. Dobson, Mapping and characterization of iron compounds in Alzheimer's tissue, J. Alzheimer's Dis. 10 (2--3) (in press). Waltz, 2002, The Verwey transition—A topical review, J. Phys., Condens. Matter, 14, R285, 10.1088/0953-8984/14/12/203 Morales, 1999, Surface and internal spin canting in γ-Fe2O3 nanoparticles' of M.P, Chem. Mater., 11, 3058, 10.1021/cm991018f B.D. Cullity, Introduction to magnetic materials. p. 413, (dB3 p / 6=25 k T / K with K=1.35 105 erg/cm3. Pankhurst, 1993, Fine particle magnetic oxides, J. Phys. Condens. Matter, 5, 8487, 10.1088/0953-8984/5/45/002 L., Néel,Theorie des proprietes magnetiques des grains fins antiferromagnetiques: superparamagnetisme et superantiferromagnetisme. P. 412–440. Cisowski, 1982, Interacting vs. noninteracting single domain behaviour in natural and synthetic samples, Earth Planet. Sci. Lett., 26, 56, 10.1016/0031-9201(81)90097-2 Gossuin, 2004, Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification, NMR Biomed., 17, 427, 10.1002/nbm.903 Mikhailova, 2005, Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy, J. R. Soc. Interface, 2, 33, 10.1098/rsif.2004.0011 Quintana, 2006, Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level, J. Struct. Biol., 153, 42, 10.1016/j.jsb.2005.11.001