Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura

Annals of Hematology - Tập 84 - Trang 807-811 - 2005
Yutaka Tsutsumi1, Hiroe Kanamori1, Hiroaki Yamato1, Nobuyuki Ehira1, Takahito Kawamura1, Shintaro Umehara1, Akio Mori1, Shinji Obara1, Nobutaka Ogura1, Junji Tanaka2, Masahiro Asaka3, Masahiro Imamura2, Nobuo Masauzi1
1Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan
2Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
3Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Tóm tắt

Helicobacter pylori (HP) eradication therapy is a useful treatment for idiopathic thrombocytopenic purpura (ITP). Some investigators have also reported the effects of proton pump inhibitor (PPI) monotherapy on ITP. We performed a randomized study of HP eradication therapy and PPI monotherapy on ITP. Four of nine patients achieved complete remission (CR), two of nine achieved partial remission (PR) in HP eradication therapy, three of eight achieved CR, and two of eight achieved PR in PPI monotherapy. No significant differences were observed in the CR + PR of these patients between HP eradication therapy and PPI monotherapy. As for cost comparisons, HP eradication therapy is cheaper than PPI monotherapy, but it is less effective.

Tài liệu tham khảo

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