Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells

European Journal of Immunology - Tập 20 Số 9 - Trang 2141-2144 - 1990
Fionula M. Brennan1, Claus Zachariae1, David Chantry1, Christian Grønhøj1, Martin Turner1, Ravinder N. Maini2, Kouji Matsushima1, Marc Feldmann1
1Charing Cross Sunley Research Centre, London, National Cancer Institute, Biological Response Modifiers Program, NCI-Frederick Cancer Research Facility, Frederick
2Kennedy Institute of Rheumatology, London

Tóm tắt

AbstractThe presence of neutrophils in the synovial joint of patients with rheumatoid arthritis (RA) is thought to be due to the activity of chemotactic factors released by activated cells in the joint. We have shown in this report, for the first time, the abundance of one such factor, interleukin 8 (IL 8), in the synovial fluid of patients both with RA and other non‐RA joint diseases, and the spontaneous production of IL8 mRNA by RA synovial cells in culture. There was no correlation between the levels of chemotactic activity and IL8 protein, suggesting that other factors with similar neutrophil chemotactic activity are also present in the synovial fluid exudate. In support of this concept neither the level of chemotactic activity nor IL8 protein levels correlated with neutrophil or leukocyte infiltration, indicating that the mechanism of migration into the inflammatory environment of the joint is complex. Such migration is likely to be due to a number of chemotactic signals in addition to IL8, which may either synergize with, or inhibit, the action of IL8.

Từ khóa


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Thông tin
Thông tin xuất bản

European Journal of Immunology

Tập 20 Số 9

2141-2144

Thông tin tác giả