5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

Molecular Cell - Tập 56 - Trang 286-297 - 2014
Gary C. Hon1, Chun-Xiao Song2, Tingting Du1, Fulai Jin1, Siddarth Selvaraj1, Ah Young Lee1, Chia-an Yen1, Zhen Ye1, Shi-Qing Mao3, Bang-An Wang3, Samantha Kuan1, Lee E. Edsall1, Boxuan Simen Zhao2, Guo-Liang Xu3, Chuan He2, Bing Ren1,4
1Ludwig Institute for Cancer Research, La Jolla, CA 92093-0653, USA
2Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
3State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
4Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, and Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA 92093