Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

Cell - Tập 183 Số 1 - Trang 126-142.e17 - 2020
Kevin R. Parker1,2, Denis Migliorini3,4,5, Eric Perkey6,7, Kathryn E. Yost1,2, Aparna Bhaduri8,9, Puneet Bagga10, Mohammad Haris10,11,12, Neil Wilson10, Fang Liu3, Khatuna Gabunia3, John Scholler3, Thomas J. Montine13, Vijay Bhoj3,14, Ravinder Reddy10, Suyash Mohan10, Ivan Maillard6, Arnold R. Kriegstein8,9, Carl H. June3,14,5, Howard Y. Chang1,15,2, Avery D. Posey3,16,17,5, Ansuman T. Satpathy13,2
1Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA
2Parker Institute for Cancer Immunotherapy, Stanford University School of Medicine, Stanford, CA, USA
3Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
4Center for Translational Research in Onco-Hematology and Department of Oncology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
5Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
6Division of Hematology-Oncology, Department of Medicine and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
7Graduate Program in Cellular and Molecular Biology and Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA
8Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
9The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA
10Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, USA
11Functional and Molecular Imaging Laboratory, Research Branch, Sidra Medicine, Doha, Qatar
12Laboratory Animal Research Center, Qatar University, Doha, Qatar
13Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
14Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
15Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
16Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA
17Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

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