Mercury‐selenium compounds and their toxicological significance: Toward a molecular understanding of the mercury‐selenium antagonism

Environmental Toxicology and Chemistry - Tập 28 Số 8 - Trang 1567-1577 - 2009
Mohammad A. K. Khan1, Fei Wang1,2
1Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
2Department of Environment and Geography, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada

Tóm tắt

AbstractThe interaction between mercury (Hg) and selenium (Se) is one of the best known examples of biological antagonism, yet the underlying mechanism remains unclear. This review focuses on the possible pathways leading to the Hg‐Se antagonism, with an emphasis on the potential Hg‐Se compounds that are responsible for the antagonism at the molecular level (i.e., bis[methylmercuric]selenide, methylmercury selenocysteinate, selenoprotein P‐bound HgSe clusters, and the biominerals HgSexS1−x). The presence of these compounds in biological systems has been suggested by direct or indirect evidence, and their chemical properties support their potentially key roles in alleviating the toxicity of Hg and Se (at high Hg and Se exposures, respectively) and deficiency of Se (at low Se exposures). Direct analytical evidences are needed, however, to confirm their in vivo presence and metabolic pathways, as well as to identify the roles of other potential Hg‐Se compounds. Further studies are also warranted for the determination of thermodynamic properties of these compounds under physiological conditions toward a better understanding of the Hg‐Se antagonism in biota, particularly under real world exposure scenarios.

Từ khóa


Tài liệu tham khảo

10.1579/0044-7447(2007)36[3:MEAHEI]2.0.CO;2

World Health Organization, 1990, Methylmercury

10.3109/10408449509089885

10.1016/S0140-6736(58)90348-9

10.1126/science.181.4096.230

10.1016/0300-483X(80)90006-2

10.1080/15287399309531777

10.1016/0300-483X(95)03297-S

Gritzka TL, 1968, Renal tubular lesions caused by mercuric chloride. Electron microscopic observations: Degeneration of the pars recta, Am J Pathol, 52, 1225

10.1038/ki.1980.157

10.3109/08923979309025999

10.1016/0006-2952(83)90404-5

10.1016/0006-2952(93)90012-L

10.1007/BF02917253

10.1016/S0149-7634(05)80217-9

10.1042/bj20020841

Mokrzan EM, 1995, Methylmercury‐thiol uptake into cultured brain capillary en‐dothelial cells on amino acid system L, J Pharmacol Exp Ther, 272, 1277

Kerper LE, 1992, Methylmercury transport across the blood‐brain barrier by an amino acid carrier, Am J Physiol, 262, R761

10.1096/fasebj.8.9.7516300

10.1016/j.bbrc.2005.03.080

10.1016/S0892-0362(98)00036-1

10.1289/ehp.98106841

10.1016/S0048-9697(01)00827-0

10.1016/S0892-0362(97)00097-4

10.1002/tera.1420180216

10.1289/ehp.95103s6135

10.1071/EN08014

10.1161/01.CIR.91.3.645

10.1006/enrs.2001.4293

Itai Y, 2004, An epidemiological study of the incidence of abnormal pregnancy in areas heavily contaminated with methylmercury, Environ Sci, 11, 8397

10.1007/BF02135970

10.1126/science.175.4026.1122

10.1016/j.scitotenv.2006.03.008

10.1139/f05-202

10.4319/lo.2001.46.7.1814

Sell JL, 1976, Influence of selenium on toxicity and metabolism of methylmercury in chicks and quail, Nutr Rep Int, 14, 439

10.1093/jn/104.5.593

10.1002/etc.5620170204

10.1016/j.neuro.2006.05.007

10.1016/0013-9351(79)90087-2

10.1016/j.ntt.2005.11.002

10.1111/j.1600-0773.1993.tb01348.x

10.1016/0147-6513(84)90017-4

10.1016/0041-008X(87)90207-9

Hansen JC, 1981, Mercury/selenium interaction: A comparative study on pigs, Nord Vet Med, 33, 5764

10.1038/245385a0

10.1016/0048-9697(75)90052-2

10.1038/254238a0

10.1289/ehp.7861

10.1577/1548-8659(1974)103<822:TOMAST>2.0.CO;2

Birge WJ, 1976, Toxicity of metal mixtures to chick embryos, Bull Environ Contam Toxicol, 16, 314318

10.3382/ps.0551423

10.1007/BF00387110

10.1016/0141-1136(94)00142-C

10.1139/A08-001

10.1016/j.ccr.2006.07.018

10.1002/0470862106.ia132

10.1002/0470862106.ia215

10.1002/0470862106.ia214

10.1021/cr050353m

10.1016/0141-1136(86)90003-6

10.1016/0147-6513(91)90074-Y

10.1289/ehp.782557

10.1139/v81-221

10.1126/science.1085941

10.1039/b819957b

10.1021/ed055p292

10.1016/S0006-3061(00)80237-9

10.1016/0167-4889(82)90038-6

10.1021/ic00177a016

10.1016/S0006-3061(00)80288-4

10.1016/S0020-1693(00)90802-8

10.1016/0162-0134(83)85044-2

Arnold AP, 1982, Mercu‐ry(II) selenolates. Crystal structures of polymeric Hg(SeMe)2 and the tetrameric pyridinates [{HgCl(py)(SeEt)}4] and [{HgCl(py)0.5[Se(CMe3)]}4], J Chem Soc Dalton Trans, 3, 607613

10.1021/ic00234a030

10.1016/0162-0134(83)85019-3

10.1128/AEM.50.2.498-502.1985

10.1128/AEM.69.9.5414-5422.2003

10.1080/00039896.1975.10666705

Magos L, 1976, Tissue levels of mercury in autopsy specimens of liver and kidney, Bull WHO, 53, 93

10.1016/j.scitotenv.2005.01.050

10.1006/taap.1995.1193

Martoja R, 1980, Identification of tiemannite as a probable product of demethylation of mercury by selenium in cetaceans: A complement to the scheme of the biological cycle of mercury, Vie Milieu, 30, 7

10.1007/s001289900796

Fang SC, 1974, Induction of carbon‐mercury cleavage enzymes in rat liver by dietary selenite, Res Comm Chem Pathol Pharmacol, 9, 579

10.1021/es040367u

Martoja R, 1977, Accumulation de granules de seleniure mercurique dans le foie d'odontocetes (Mammiferes, Cetaces): Un mecanisme possible de detoxication du methylmercure par le selenium, C R Hebd Seanc Acad Sci Paris D, 285, 109

10.1017/S0025315400044040

10.3354/meps135137

10.1006/eesa.1995.1035

10.1016/0141-1136(94)00142-C

10.1016/S0048-9697(02)00684-8

10.1016/S0045-6535(97)00167-7

Hansen JC, 1986, Environmental exposure to heavy metals in North Greenland, Arctic Mededical Research, 41, 21

Hansen JC, 1988, Blood mercury concentrations in birthgiving Greenlandic women, Arctic Mededical Research, 47, 175

10.4319/lo.2004.49.6.2276

10.3109/10408448009037490

Clarkson TW, 1969, Chemical Fallout, 274

10.3181/00379727-145-37894

10.1006/bbrc.1996.6036

10.1007/s00244-004-3188-9

10.1016/S0031-6989(74)80006-8

10.1007/BF00293656

10.1016/0091-3057(80)90277-4

10.1016/0041-008X(77)90118-1

10.1007/BF01607855

10.1289/ehp.782571

Welsh S, 1979, The protective effect of vitamin E and N,′‐diphenyl‐p‐phenylenediamine (DPPD) against methyl mercury toxicity in the rat, J Nutr, 109, 1673, 10.1093/jn/109.10.1673

10.1016/B978-0-12-718240-7.50013-9

Reilly C, 2006, Selenium in Food and Health

Raymond LJ, 2004, Mercury: Selenium interactions and health implications, Seychelles Medical and Dental Journal, 7, 72

10.1007/0-387-33827-6_21

10.1007/BF01706230

10.1111/j.1365-2621.1974.tb00974.x

10.1016/0039-9140(88)80129-2

Haines KJR, 2004, Relationship between mercury and selenium in the brain of river otter (Lutra canadensis) and wild mink (Mustela vison) from Nova Scotia, Canada, RMZ Materials and Geoenvironment, 51, 1028

10.1016/0003-2697(79)90143-X

10.1038/254238a0

10.1038/268073a0

10.1016/0006-291X(79)91774-1

Naganuma A, 1980, Bis(methylmercuric) selenide as a reaction product from methylmercury and selenite in rabbit blood, Res Comm Chem Pathol Pharmacol, 27, 163

10.1016/0009-2797(79)90175-3

Masukowa T, 1982, Formation and possible role of bis(methylmercury) selenide in rats treated with methylmercury and selenite, Biochem Pharmacol, 31, 7578

Naganuma A, 1980, Interaction of methylmercury and selenium in mouse: Formation and decomposition of bis(methylmercuric)selenide, Res Comm Chem Pathol Pharmacol, 30, 301

10.1016/0045-6535(81)90240-X

10.1016/0009-2797(77)90125-9

10.1038/275635a0

10.1016/S0022-328X(00)81048-7

10.1016/S0020-1693(00)81189-5

10.1007/BF02789096

Martell AE, 1995, Metal Complexes in Aqueous Solutions

10.1021/ja00460a072

10.1038/204468a0

10.1146/annurev.nutr.24.012003.132120

10.1007/0-387-33827-6_9

10.1006/taap.1996.8095

10.1016/S0167-4838(98)00221-0

10.1021/tx000050h

10.1016/S0048-9697(00)00592-1

Earley JW, 1950, Description and synthesis of the selenide minerals, Am Minerol, 35, 337

10.1021/jp0274684

10.2183/pjab.77.178

10.1039/dt9750000438

10.1016/0006-2952(96)00241-9

Schecher WD, 2003, MINEQL+: A Chemical Equilibrium Program for Personal Computers—User's Manual