Bidirectional signaling between the cytoskeleton and integrins

Schwartz, 1995, Integrins: emerging paradigms of signal transduction, Annu Rev Cell Biol, 11, 549, 10.1146/annurev.cb.11.110195.003001 Clark, 1995, Integrins and signal transduction pathways: the road taken, Science, 268, 233, 10.1126/science.7716514 Burridge, 1996, Focal adhesions, contractility and signaling, Annu Rev Cell Dev Biol, 12, 463, 10.1146/annurev.cellbio.12.1.463 Hemler, 1998, Integrin associated proteins, Curr Opin Cell Biol, 10, 578, 10.1016/S0955-0674(98)80032-X Hughes, 1998, Integrin affinity modulation, Trends Cell Biol, 8, 359, 10.1016/S0962-8924(98)01339-7 Howe, 1998, Integrin signaling and cell growth control, Curr Opin Cell Biol, 10, 220, 10.1016/S0955-0674(98)80144-0 Wang, 1993, Mechanotransduction across the cell surface and through the cytoskeleton, Science, 260, 1124, 10.1126/science.7684161 Miyamoto, 1995, Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function, Science, 267, 883, 10.1126/science.7846531 Felsenfeld, 1996, Ligand binding regulates the directed movement of α5β1 integrins on fibroblasts, Nature, 383, 438, 10.1038/383438a0 Hall, 1998, Rho GTPases and the actin cytoskeleton, Science, 279, 509, 10.1126/science.279.5350.509 Van Aelst, 1997, Rho GTPases and signaling networks, Genes Dev, 11, 2295, 10.1101/gad.11.18.2295 Whitehead, 1997, Dbl family proteins, Biochim Biophys Acta, 1332, F1 Burridge, 1997, Focal adhesion assembly, Trends Cell Biol, 7, 342, 10.1016/S0962-8924(97)01127-6 Kimura, 1996, Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase), Science, 273, 245, 10.1126/science.273.5272.245 Chrzanowska-Wodnicka, 1996, Rho-stimulated contractility drives the formation of stress fibers and focal adhesions, J Cell Biol, 133, 1403, 10.1083/jcb.133.6.1403 Amano, 1996, Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase), J Biol Chem, 271, 20246, 10.1074/jbc.271.34.20246 Leung, 1996, The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton, Mol Cell Biol, 16, 5313, 10.1128/MCB.16.10.5313 Amano, 1997, Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase, Science, 275, 1308, 10.1126/science.275.5304.1308 Ishizaki, 1997, p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions, FEBS Lett, 404, 118, 10.1016/S0014-5793(97)00107-5 Chong, 1994, The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells, Cell, 79, 507, 10.1016/0092-8674(94)90259-3 Weekes, 1996, Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites, Biochem J, 314, 827, 10.1042/bj3140827 Gilmore, 1996, Regulation of vinculin binding to talin and actin by phosphatidylinositol-4-5-bisphosphate, Nature, 381, 531, 10.1038/381531a0 Niggli, 1995, Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin, FEBS Lett, 376, 172, 10.1016/0014-5793(95)01270-1 Hirao, 1996, Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway, J Cell Biol, 135, 37, 10.1083/jcb.135.1.37 Sells, 1997, Human p21-activated kinase (pak1) regulates actin organization in mammalian cells, Curr Biol, 7, 202, 10.1016/S0960-9822(97)70091-5 Sanders, 1999, Inhibition of myosin light chain kinase by p21-activated kinase (PAK), Science, 10.1126/science.283.5410.2083 Leung, 1998, Myotonic dystrophy kinase-related cdc42-binding kinase acts as a cdc42 effector in promoting cytoskeletal reorganization, Mol Cell Biol, 18, 130, 10.1128/MCB.18.1.130 Joneson, 1996, RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase, Science, 274, 1374, 10.1126/science.274.5291.1374 Westwick, 1997, Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways, Mol Cell Biol, 17, 1324, 10.1128/MCB.17.3.1324 Lamarche, 1996, Rac and Cdc42 induce actin polymerization and G1 cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade, Cell, 87, 519, 10.1016/S0092-8674(00)81371-9 Zhao, 1998, A conserved negative regulatory region in alpha-pak - inhibition of pak kinases reveals their morphological roles downstream of Cdc42 and Rac1, Mol Cell Biol, 18, 2153, 10.1128/MCB.18.4.2153 Manser, 1998, Pak kinases are directly coupled to the pix family of nucleotide exchange factors, Mol Cell, 1, 183, 10.1016/S1097-2765(00)80019-2 Hartwig, 1995, Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets, Cell, 82, 643, 10.1016/0092-8674(95)90036-5 Keely, 1997, Cdc42 and rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K, Nature, 390, 632, 10.1038/37656 Van Aelst, 1996, Identification of a novel Rac1-interacting protein involved in membrane ruffling, EMBO J, 15, 3778, 10.1002/j.1460-2075.1996.tb00751.x Kuroda, 1996, Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1, J Biol Chem, 271, 23363, 10.1074/jbc.271.38.23363 Bashour, 1997, IQGAP, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments, J Cell Biol, 137, 1555, 10.1083/jcb.137.7.1555 Aspenstrom, 1996, Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome, Curr Biol, 6, 70, 10.1016/S0960-9822(02)00423-2 Symons, 1996, Wiskott-Aldrich syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization, Cell, 84, 723, 10.1016/S0092-8674(00)81050-8 Nobes, 1998, A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion, J Cell Biol, 141, 187, 10.1083/jcb.141.1.187 Guasch, 1998, RhoE regulates actin cytoskeleton organization and cell migration, Mol Cell Biol, 18, 4761, 10.1128/MCB.18.8.4761 Schliwa, 1984, Tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells, J Cell Biol, 99, 1045, 10.1083/jcb.99.3.1045 Vuori, 1993, Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin, J Biol Chem, 268, 21459, 10.1016/S0021-9258(20)80557-2 Woods, 1992, Protein kinase C involvement in focal adhesion formation, J Cell Sci, 101, 277, 10.1242/jcs.101.2.277 Lamb, 1988, Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase, J Cell Biol, 106, 1955, 10.1083/jcb.106.6.1955 Fernandez, 1990, Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells, J Cell Biol, 111, 103, 10.1083/jcb.111.1.103 Volberg, 1994, Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system, Cell Motil Cytoskeleton, 29, 321, 10.1002/cm.970290405 Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7 Lampugnani, 1990, Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP, Lab Invest, 63, 521 Glass, 1993, Regulation of integrin-mediated adhesion at focal contacts by cyclic AMP, J Cell Physiol, 157, 296, 10.1002/jcp.1041570212 Turner, 1989, The role of phosphorylation and limited proteolytic cleavage of talin and vinculin in the disruption of focal adhesion integrity, J Biol Chem, 264, 11938, 10.1016/S0021-9258(18)80157-0 Han, 1996, Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP, J Biol Chem, 271, 29211, 10.1074/jbc.271.46.29211 Troyer, 1995, Tyrosine phosphorylation of focal adhesion kinase (p125FAK): regulation by cAMP and thrombin in mesangial cells, J Am Soc Nephrol, 7, 415, 10.1681/ASN.V73415 Lang, 1996, Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes, EMBO J, 15, 510, 10.1002/j.1460-2075.1996.tb00383.x Laudanna, 1997, Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants, J Biol Chem, 272, 24141, 10.1074/jbc.272.39.24141 Kreisberg, 1997, Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cells, Am J Physiol, 273, F283 Busca, 1998, Inhibition of Rho is required for cAMP-induced melanoma cell differentiation, Mol Biol Cell, 9, 1367, 10.1091/mbc.9.6.1367 Dong, 1998, cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROK-α, J Biol Chem, 273, 22554, 10.1074/jbc.273.35.22554 He, 1994, Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway, J Cell Biol, 126, 457, 10.1083/jcb.126.2.457 Xie, 1998, EGF receptor regulation of cell motility — EGF induces disassembly of focal adhesions independently of the motility-associated PLC-gamma signaling pathway, J Cell Sci, 111, 615, 10.1242/jcs.111.5.615 Ojaniemi, 1997, Epidermal growth factor modulates tyrosine phosphorylation of p130Cas, J Biol Chem, 272, 25993, 10.1074/jbc.272.41.25993 Knight, 1995, Divergent insulin and plalelet-derived growth factor regulation of focal adhesion kinase (pp125FAK) tyrosine phosphorylation, and rearrrangement of actin stress fibers, J Biol Chem, 270, 10199, 10.1074/jbc.270.17.10199 Rankin, 1994, Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin, J Biol Chem, 269, 704, 10.1016/S0021-9258(17)42406-9 Chang, 1995, c-Src regulates the simultaneous rearrangements of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation, J Cell Biol, 130, 355, 10.1083/jcb.130.2.355 Nobes, 1995, Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81, 53, 10.1016/0092-8674(95)90370-4 Ridley, 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, 70, 401, 10.1016/0092-8674(92)90164-8 Kozma, 1995, The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts, Mol Cell Biol, 15, 1942, 10.1128/MCB.15.4.1942 Kozma, 1997, Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid, Mol Cell Biol, 17, 1201, 10.1128/MCB.17.3.1201 van Leeuwen, 1997, The guanine nucleotide exchange factor TIAM1 affects neuronal morphology-opposing roles for the small GTPases Rac and Rho, J Cell Biol, 139, 797, 10.1083/jcb.139.3.797 Manser, 1997, Expression of constitutively active alpha-pak reveals effects of the kinase on actin and focal complexes, Mol Cell Biol, 17, 1129, 10.1128/MCB.17.3.1129 Frost, 1998, Differential effects of PAK1-activating mutations reveal activity-dependent and –independent effects on cytoskeletal regulation, J Biol Chem, 273, 28191, 10.1074/jbc.273.43.28191 Richardson, 1995, Signal transduction through integrins: a central role for focal adhesion kinase•, Bioessays, 17, 229, 10.1002/bies.950170309 Fincham, 1995, v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts, Oncogene, 10, 2247 Gilmore, 1996, Inhibition of FAK signalling in focal adhesions decreases cell motility and proliferation, Mol Biol Cell, 7, 1209, 10.1091/mbc.7.8.1209 Nobes, 1995, Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors, J Cell Sci, 108, 225, 10.1242/jcs.108.1.225 Gulbins, 1993, Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation, Science, 260, 822, 10.1126/science.8484124 Han, 1997, Lck regulates Vav activation of members of the Rho family of GTPases, Mol Cell Biol, 17, 1346, 10.1128/MCB.17.3.1346 Miranti, 1998, Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1, Curr Biol, 8, 1289, 10.1016/S0960-9822(07)00559-3 Cichowski, 1996, Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95Vav, in platelets, J Biol Chem, 271, 7544, 10.1074/jbc.271.13.7544 Gulbins, 1994, Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells, J Immunol, 152, 2123, 10.4049/jimmunol.152.5.2123 Yamauchi, 1995, Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling, Proc Natl Acad Sci USA, 92, 664, 10.1073/pnas.92.3.664 Schneider, 1998, Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers, Cell Adhesion Commun, 5, 207, 10.3109/15419069809040292 Black, 1997, Idenification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions, EMBO J, 16, 2730, 10.1093/emboj/16.10.2730 Persson, 1997, The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions, EMBO J, 16, 2307, 10.1093/emboj/16.9.2307 Yu, 1998, Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion, J Biol Chem, 273, 21125, 10.1074/jbc.273.33.21125 Liu, 1996, Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130cas, J Biol Chem, 271, 31290, 10.1074/jbc.271.49.31290 Liu, 1998, Protein tyrosine phosphatase 1B negatively regulates integrin signaling, Curr Biol, 8, 173, 10.1016/S0960-9822(98)70066-1 Arregui, 1998, Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B, J Cell Biol, 143, 861, 10.1083/jcb.143.3.861 Garton, 1996, Identification of P130(CAS) as a substrate for the cytosolic protein tyrosine phosphatase PTP-Pest, Mol Cell Biol, 16, 6408, 10.1128/MCB.16.11.6408 Cote, 1998, Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model, Biochem, 37, 13128, 10.1021/bi981259l Shen, 1998, Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin, J Biol Chem, 273, 6474, 10.1074/jbc.273.11.6474 Garton, 1999, Regulation of motility by the protein tyrosine phosphatase PTP-PEST, J Biol Chem, 274, 3811, 10.1074/jbc.274.6.3811 Tamura, 1998, Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN, Science, 280, 1614, 10.1126/science.280.5369.1614 Maehama, 1998, The tumor supressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate, J Biol Chem, 273, 13375, 10.1074/jbc.273.22.13375 Stambolic, 1998, Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN, Cell, 95, 29, 10.1016/S0092-8674(00)81780-8 Myers, 1998, The lipid phosphatase activity of PTEN is critical for its tumor suppressor function, Proc Natl Acad Sci USA, 95, 13513, 10.1073/pnas.95.23.13513 Wu, 1998, The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway, Proc Natl Acad Sci USA, 95, 15587, 10.1073/pnas.95.26.15587 Serra-Pages, 1995, The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions, EMBO J, 14, 2827, 10.1002/j.1460-2075.1995.tb07282.x Debant, 1996, The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate Rac-specific and Rho-specific guanine nucleotide exchange factor domains, Proc Natl Acad Sci USA, 93, 5466, 10.1073/pnas.93.11.5466 Saras, 1997, A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1, J Biol Chem, 272, 24333, 10.1074/jbc.272.39.24333 Fincham, 1998, The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility, EMBO J, 17, 81, 10.1093/emboj/17.1.81 Ilic, 1995, Reduced cell motility and enhanced focal contact formation in cells from FAK-deficient mice, Nature, 377, 539, 10.1038/377539a0 Cary, 1996, Stimulation of cell migration by over-expression of focal adhesion kinse and its association with Src and Fyn, J Cell Sci, 109, 1787, 10.1242/jcs.109.7.1787 Owens, 1995, Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors, Cancer Res, 55, 2752 Hildebrand, 1996, An SH3 domain-containing GTPase-activating protein for Rho, Mol Cell Biol, 16, 3169, 10.1128/MCB.16.6.3169 Huttenlocher, 1995, Adhesion in cell migration, Curr Opin Cell Biol, 7, 697, 10.1016/0955-0674(95)80112-X Greenwood, 1998, Signaling of de-adhesion in cellular regulation and motility, Microsc Res Tech, 43, 420, 10.1002/(SICI)1097-0029(19981201)43:5<420::AID-JEMT8>3.0.CO;2-B Murphy-Ullrich, 1991, Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum], J Cell Biol, 115, 1127, 10.1083/jcb.115.4.1127 Murphy-Ullrich, 1989, Thrombospondin modulates focal adhesions in endothelial cells, J Cell Biol, 109, 1309, 10.1083/jcb.109.3.1309 Murphy-Ullrich, 1996, Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly, J Cell Sci, 109, 2499, 10.1242/jcs.109.10.2499 Greenwood, 1998, Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinase, J Biol Chem, 273, 1755, 10.1074/jbc.273.3.1755 Ivanova, 1976, Effect of colcemid on the spreading of fibroblasts in culture, Exp Cell Res, 101, 207, 10.1016/0014-4827(76)90431-6 Bershadsky, 1991, Pseudopodial activity at the active edge of migrating fibroblast is decreased after drug-induced microtubule depolymerization, Cell Motil Cytoskeleton, 19, 152, 10.1002/cm.970190303 Vasiliev, 1970, Effect of colcemid on the locomotory behavior of fibroblasts, J Embryol Exp Morphol, 24, 625 Danowski, 1989, Fibroblast contractility and actin organization are stimulated by microtubule inhibitors, J Cell Sci, 93, 255, 10.1242/jcs.93.2.255 Bershadsky, 1996, Involvement of microtubules in the control of adhesion-dependent signal transduction, Curr Biol, 6, 1279, 10.1016/S0960-9822(02)70714-8 Enomoto, 1996, Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the Rho signal cascade, Cell Struct Funct, 21, 317, 10.1247/csf.21.317 Pletjushkina, 1998, Maturation of cell-substratum focal adhesions induced by depolymerization of microtubules is induced by increased cortical tension, Cell Adhesion Comm, 5, 121, 10.3109/15419069809040286 Kolodney, 1995, Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain, Proc Natl Acad Sci USA, 92, 10252, 10.1073/pnas.92.22.10252 Zhang, 1997, Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through rho-dependent actin stress fiber formation and cell contraction, Mol Biol Cell, 8, 1415, 10.1091/mbc.8.8.1415 Liu, 1998, Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho, Cell Adhes Commun, 5, 249, 10.3109/15419069809040295 Ren, 1999, Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton, EMBO J, 18, 578, 10.1093/emboj/18.3.578 Ren, 1998, Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and rho GTPases, J Biol Chem, 273, 34954, 10.1074/jbc.273.52.34954 Cook, 1998, Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid, J Cell Biol, 141, 175, 10.1083/jcb.141.1.175 Kaverina, 1998, Targeting, capture, and stabilization of microtubules at early focal adhesions, J Cell Biol, 142, 181, 10.1083/jcb.142.1.181 Paterson, 1990, Microinjection of recombinant p21rho induces rapid changes in cell morphology, J Cell Biol, 111, 1001, 10.1083/jcb.111.3.1001 Sin, 1998, RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network, Mol Cell Biol, 18, 6325, 10.1128/MCB.18.11.6325 Inagaki, 1996, Dynamic properties of intermediate filaments: regulation by phosphorylation, Bioessays, 18, 481, 10.1002/bies.950180610 Tint, 1991, Evidence that intermediate filament reorganization is induced by ATP-dependent contraction of the actomyosin cortex in permeabilized fibroblasts, J Cell Sci, 98, 375, 10.1242/jcs.98.3.375 Clark, 1998, Integrin-mediated signals regulated by members of the Rho family of GTPases, J Cell Biol, 142, 573, 10.1083/jcb.142.2.573 Price, 1998, Activation of Rac and Cdc42 by integrins mediates cell spreading, Mol Biol Cell, 9, 1863, 10.1091/mbc.9.7.1863 Barry, 1997, Requirement for Rho in integrin signalling, Cell Adhes Commun, 4, 387, 10.3109/15419069709004456 Polte, 1995, Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas, Proc Natl Acad Sci USA, 92, 10678, 10.1073/pnas.92.23.10678 Bockholt, 1995, An examination of focal adhesion formation and tyrosine phosphorylation in fibroblasts isolated from src(−), fyn(−), and yes(−) mice, Cell Adhes Commun, 3, 91, 10.3109/15419069509081279 Petch, 1995, Adhesion-induced tyrosine phosphorylation of the p130 src substrate, J Cell Sci, 108, 1371, 10.1242/jcs.108.4.1371 Nojima, 1995, Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homolgy 2-binding motifs, J Biol Chem, 270, 15398, 10.1074/jbc.270.25.15398 Vuori, 1995, Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix, J Biol Chem, 270, 22259, 10.1074/jbc.270.38.22259 Kirsch, 1998, Direct binding of p130cas to the guanine nucleotide exchange factor C3G, J Biol Chem, 273, 25673, 10.1074/jbc.273.40.25673 Honda, 1998, Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas, Nat Genet, 19, 361, 10.1038/1246 Brugge, 1998, Casting light on focal adhesions, Nat Genet, 19, 309, 10.1038/1189 Altun-Gultekin, 1998, Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-crk adaptor protein, Mol Cell Biol, 18, 3044, 10.1128/MCB.18.5.3044 Cary, 1998, Identification of p130cas as a mediator of focal adhesion kinase-promoted cell migration, J Cell Biol, 140, 211, 10.1083/jcb.140.1.211 Klemke, 1998, CAS/Crk coupling serves as a ‘molecular switch’ for induction of cell migration, J Cell Biol, 140, 961, 10.1083/jcb.140.4.961 Kiyokawa, 1998, Evidence that DOCK180 up-regulates signals from the CrkII-p130Cas complex, J Biol Chem, 273, 24479, 10.1074/jbc.273.38.24479 Dolfi, 1998, The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway, Proc Natl Acad Sci USA, 95, 15394, 10.1073/pnas.95.26.15394 Nolan, 1998, Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes, Genes Devel, 12, 3337, 10.1101/gad.12.21.3337 Kiyokawa, 1998, Activation of Rac1 by a Crk SH3-binding protein, DOCK180, Genes Dev, 12, 3331, 10.1101/gad.12.21.3331 Hynes, 1990 Zhang, 1994, Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid, J Cell Biol, 127, 1447, 10.1083/jcb.127.5.1447 Zhong, 1998, Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly, J Cell Biol, 141, 539, 10.1083/jcb.141.2.539 Christopher, 1997, Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells, J Cell Sci, 110, 569, 10.1242/jcs.110.5.569 Hocking, 1994, Fibronectin’s III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin, J Biol Chem, 269, 19183, 10.1016/S0021-9258(17)32292-5 Ingham, 1997, Cryptic self-association sites in type III modules of fibronectin, J Biol Chem, 272, 1718, 10.1074/jbc.272.3.1718 Ohashi, 1999, Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein, Proc Natl Acad Sci USA, 96, 2153, 10.1073/pnas.96.5.2153 Sechler, 1998, Control of cell cycle progression by fibronectin matrix architecture, J Biol Chem, 273, 25533, 10.1074/jbc.273.40.25533 Mercurius, 1998, Inhibition of vascular smooth muscle cell growth by inhibition of fibronectin matrix assembly, Circ Res, 82, 548, 10.1161/01.RES.82.5.548