Weight loss is a critical factor to reduce inflammation

Clinical Nutrition ESPEN - Tập 28 - Trang 21-35 - 2018
Vittorio Emanuele Bianchi1
1Department of Nutrition, Metabolism, and Endocrinology, Clinical Center Stella Maris, Strada Rovereta, 42, 47898, Falciano, San Marino

Tài liệu tham khảo

Shoelson, 2006, Inflammation and insulin resistance, J Clin Invest, 116, 1793, 10.1172/JCI29069 Wang, 2013, Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis, Diabetes Care, 36, 166, 10.2337/dc12-0702 Gui, 2012, Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery, Mediat Inflamm, 2012, 693083, 10.1155/2012/693083 Ridker, 2003, C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women, Circulation, 107, 391, 10.1161/01.CIR.0000055014.62083.05 Slattery, 2009, Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology, Cancer Prev Res (Phila), 2, 922, 10.1158/1940-6207.CAPR-08-0191 Schetter, 2010, Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways, Carcinogenesis, 31, 37, 10.1093/carcin/bgp272 Calder, 2009, Inflammatory disease processes and interactions with nutrition, Br J Nutr, 101, S1 Makki, 2013, Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines, ISRN Inflamm, 2013, 139239, 10.1155/2013/139239 Pepys, 2003, C-reactive protein: a critical update, J Clin Invest, 111, 1805, 10.1172/JCI200318921 Timpson, 2005, C-reactive protein and its role in metabolic syndrome: mendelian randomisation study, Lancet, 366, 1954, 10.1016/S0140-6736(05)67786-0 Singh, 2017, Systematic review and meta-analysis of the association between C-Reactive protein and major cardiovascular events in patients with peripheral artery disease, Eur J Vasc Endovasc Surg, 54, 220, 10.1016/j.ejvs.2017.05.009 de Boer, 2018, Association of cardiovascular biomarkers with incident heart failure with preserved and reduced ejection fraction, JAMA Cardiol, 3, 215, 10.1001/jamacardio.2017.4987 Spoto, 2014, Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity, Nutr Metab Cardiovasc Dis, 24, 1137, 10.1016/j.numecd.2014.04.017 Ford, 2002, Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey, JAMA, 287, 356, 10.1001/jama.287.3.356 Wolk, 2016, Prognostic value of adipokines in predicting cardiovascular outcome: explaining the obesity paradox, Mayo Clin Proc, 91, 858, 10.1016/j.mayocp.2016.03.020 de Luca, 2008, Inflammation and insulin resistance, FEBS Lett, 582, 97, 10.1016/j.febslet.2007.11.057 King, 2016, Selective insulin resistance and the development of cardiovascular diseases in diabetes: the 2015 edwin Bierman Award lecture, Diabetes, 65, 1462, 10.2337/db16-0152 Callaghan, 2013, The metabolic syndrome and neuropathy: therapeutic challenges and opportunities, Ann Neurol, 74, 397, 10.1002/ana.23986 Boden, 2017, Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study, Nutr J, 16, 21, 10.1186/s12937-017-0243-8 Williamson, 2012, Insulin resistance in the brain: an old-age or new-age problem?, Biochem Pharmacol, 84, 737, 10.1016/j.bcp.2012.05.007 Prasad, 2012, Age-associated chronic diseases require age-old medicine: role of chronic inflammation, Prev Med, 54, S29, 10.1016/j.ypmed.2011.11.011 Phillips, 2013, Does inflammation determine metabolic health status in obese and nonobese adults?, J Clin Endocrinol Metab, 98, E1610, 10.1210/jc.2013-2038 Rock, 2016, Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status, Metabolism, 65, 1605, 10.1016/j.metabol.2016.07.008 Meydani, 2016, Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans, Aging (Albany NY), 8, 1416, 10.18632/aging.100994 Hu, 2015, The effects of a low-carbohydrate diet vs. a low-fat diet on novel cardiovascular risk factors: a randomized controlled trial, Nutrients, 7, 7978, 10.3390/nu7095377 Beavers, 2015, Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis, Osteoarthritis Cartilage, 23, 249, 10.1016/j.joca.2014.11.005 Fisher, 2011, Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women, Obesity (Silver Spring), 19, 1131, 10.1038/oby.2010.310 Salas-Salvado, 2008, Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease, Eur J Clin Nutr, 62, 651, 10.1038/sj.ejcn.1602762 Nicklas, 2013, Effect of dietary composition of weight loss diets on high-sensitivity c-reactive protein: the Randomized POUNDS LOST trial, Obesity (Silver Spring), 21, 681, 10.1002/oby.20072 Stendell-Hollis, 2013, A comparison of Mediterranean-style and MyPyramid diets on weight loss and inflammatory biomarkers in postpartum breastfeeding women, J Womens Health (Larchmt), 22, 48, 10.1089/jwh.2012.3707 Heggen, 2012, Effect of a low-fat versus a low-gycemic-load diet on inflammatory biomarker and adipokine concentrations, Metab Syndr Relat Disord, 10, 437, 10.1089/met.2012.0012 Gogebakan, 2011, Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial, Circulation, 124, 2829, 10.1161/CIRCULATIONAHA.111.033274 Imayama, 2012, Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial, Cancer Res, 72, 2314, 10.1158/0008-5472.CAN-11-3092 Golan, 2012, Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control, Nutrition, 28, 131, 10.1016/j.nut.2011.04.001 van Bussel, 2015, A healthy diet is associated with less endothelial dysfunction and less low-grade inflammation over a 7-year period in adults at risk of cardiovascular disease, J Nutr, 145, 532 Juanola-Falgarona, 2014, Effect of the glycemic index of the diet on weight loss, modulation of satiety, inflammation, and other metabolic risk factors: a randomized controlled trial, Am J Clin Nutr, 100, 27, 10.3945/ajcn.113.081216 Merra, 2017, Effects of very-low-calorie diet on body composition, metabolic state, and genes expression: a randomized double-blind placebo-controlled trial, Eur Rev Med Pharmacol Sci, 21, 329 Dyer, 2017, Effect of a mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis, J Nutr Health Aging, 21, 562, 10.1007/s12603-016-0806-y Moller, 2016, Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and oxylipins in obese subjects, Prostaglandins Leukot Essent Fatty Acids, 106, 39, 10.1016/j.plefa.2015.12.001 Kirwan, 2016, A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial, J Nutr, 146, 2244 Pedersen, 2016, Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: a randomized trial, Atherosclerosis, 246, 221, 10.1016/j.atherosclerosis.2016.01.001 Magkos, 2016, Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity, Cell Metab, 23, 591, 10.1016/j.cmet.2016.02.005 Song, 2016, A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study, Eur J Nutr, 55, 237, 10.1007/s00394-015-0841-1 Ho, 2015, Effects of a 12-month moderate weight loss intervention on insulin sensitivity and inflammation status in nondiabetic overweight and obese subjects, Horm Metab Res, 47, 289 Ryan, 2014, Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women, J Am Geriatr Soc, 62, 607, 10.1111/jgs.12749 Khoo, 2015, Exercise-induced weight loss is more effective than dieting for improving adipokine profile, insulin resistance, and inflammation in obese men, Int J Sport Nutr Exerc Metab, 25, 566, 10.1123/ijsnem.2015-0025 Miller, 2014, Effects of a community-based weight loss intervention on adipose tissue circulating factors, Diabetes Metab Syndr, 8, 205, 10.1016/j.dsx.2014.09.003 Lopez-Legarrea, 2014, The protein type within a hypocaloric diet affects obesity-related inflammation: the RESMENA project, Nutrition, 30, 424, 10.1016/j.nut.2013.09.009 Strasser, 2015, Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults, Eur J Nutr, 54, 101, 10.1007/s00394-014-0690-3 Trussardi Fayh, 2013, Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomised clinical trial, Br J Nutr, 110, 486, 10.1017/S0007114512005442 Blesso, 2013, Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome, J Clin Lipidol, 7, 463, 10.1016/j.jacl.2013.03.008 Tajik, 2013, Effect of diet-induced weight loss on inflammatory cytokines in obese women, J Endocrinol Invest, 36, 211 Neuhouser, 2012, A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults, J Nutr, 142, 369 Bougoulia, 2006, Plasma interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors, Hormones (Athens), 5, 192, 10.14310/horm.2002.11182 Kasim-Karakas, 2006, Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake, Am J Clin Nutr, 83, 774, 10.1093/ajcn/83.4.774 Giannopoulou, 2005, Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes, Metabolism, 54, 866, 10.1016/j.metabol.2005.01.033 Jellema, 2004, Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state, Eur J Clin Invest, 34, 766, 10.1111/j.1365-2362.2004.01414.x Sharman, 2004, Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men, Clin Sci (Lond), 107, 365, 10.1042/CS20040111 Arvidsson, 2004, Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women, Diabetes, 53, 1966, 10.2337/diabetes.53.8.1966 Seshadri, 2004, A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity, Am J Med, 117, 398, 10.1016/j.amjmed.2004.04.009 Xydakis, 2004, Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction, J Clin Endocrinol Metab, 89, 2697, 10.1210/jc.2003-031826 You, 2004, Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women, J Clin Endocrinol Metab, 89, 1739, 10.1210/jc.2003-031310 Bruun, 2003, Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men, Eur J Endocrinol, 148, 535, 10.1530/eje.0.1480535 Bruun, 2002, Opposite regulation of interleukin-8 and tumor necrosis factor-alpha by weight loss, Obes Res, 10, 499, 10.1038/oby.2002.68 Bastard, 2000, Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss, J Clin Endocrinol Metab, 85, 3338 Tchernof, 2002, Weight loss reduces C-reactive protein levels in obese postmenopausal women, Circulation, 105, 564, 10.1161/hc0502.103331 Heilbronn, 2001, Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women, Arterioscler Thromb Vasc Biol, 21, 968, 10.1161/01.ATV.21.6.968 Johnstone, 2011, Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile, Br J Nutr, 106, 282, 10.1017/S0007114511000092 Hermsdorff, 2009, Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects, Endocrine, 36, 445, 10.1007/s12020-009-9248-1 Christiansen, 2010, Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin, J Clin Endocrinol Metab, 95, 911, 10.1210/jc.2008-2505 Davis, 2011, Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes, J Diabet Complicat, 25, 371, 10.1016/j.jdiacomp.2011.08.001 Bladbjerg, 2011, Effects on markers of inflammation and endothelial cell function of three ad libitum diets differing in type and amount of fat and carbohydrate: a 6-month randomised study in obese individuals, Br J Nutr, 106, 123, 10.1017/S0007114510005829 Sola, 2009, Parameters of inflammation in morbid obesity: lack of effect of moderate weight loss, Obes Surg, 19, 571, 10.1007/s11695-008-9772-8 Campion, 2009, TNF-alpha promoter methylation as a predictive biomarker for weight-loss response, Obesity (Silver Spring), 17, 1293, 10.1038/oby.2008.679 de Mello, 2008, Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome, Metabolism, 57, 192, 10.1016/j.metabol.2007.08.024 Madsen, 2008, Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study, Eur J Endocrinol, 158, 179, 10.1530/EJE-07-0721 Lima, 2013, Visceral fat resection in humans: effect on insulin sensitivity, beta-cell function, adipokines, and inflammatory markers, Obesity (Silver Spring), 21, E182, 10.1002/oby.20030 Dalmas, 2011, Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction, Am J Clin Nutr, 94, 450, 10.3945/ajcn.111.013771 Gogebakan, 2015, GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial, Diabetologia, 58, 1759, 10.1007/s00125-015-3618-4 Ramel, 2010, Effects of weight loss and seafood consumption on inflammation parameters in young, overweight and obese European men and women during 8 weeks of energy restriction, Eur J Clin Nutr, 64, 987, 10.1038/ejcn.2010.99 Marques-Rocha, 2016, Expression of inflammation-related miRNAs in white blood cells from subjects with metabolic syndrome after 8 wk of following a Mediterranean diet-based weight loss program, Nutrition, 32, 48, 10.1016/j.nut.2015.06.008 Hermsdorff, 2011, A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects, Eur J Nutr, 50, 61, 10.1007/s00394-010-0115-x Pendyala, 2011, Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis, Am J Clin Nutr, 93, 234, 10.3945/ajcn.110.002683 Clement, 2004, Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects, FASEB J, 18, 1657, 10.1096/fj.04-2204com Bielohuby, 2011, Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein, Am J Physiol Endocrinol Metab, 300, E65, 10.1152/ajpendo.00478.2010 Kord-Varkaneh, 2018, Association of serum leptin with all-cause and disease specific mortality: a meta-analysis of prospective observational studies, Horm Metab Res, 50, 509, 10.1055/a-0620-8671 Lips, 2016, Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass, Metabolism, 65, 1614, 10.1016/j.metabol.2016.07.013 Santos, 2014, Effect of bariatric surgery on weight loss, inflammation, iron metabolism, and lipid profile, Scand J Surg, 103, 21, 10.1177/1457496913490467 Illan-Gomez, 2012, Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery, Obes Surg, 22, 950, 10.1007/s11695-012-0643-y Bueter, 2010, Renal cytokines improve early after bariatric surgery, Br J Surg, 97, 1838, 10.1002/bjs.7264 Moschen, 2010, Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression, Gut, 59, 1259, 10.1136/gut.2010.214577 Cancello, 2005, Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss, Diabetes, 54, 2277, 10.2337/diabetes.54.8.2277 Hanusch-Enserer, 2003, Acute-phase response and immunological markers in morbid obese patients and patients following adjustable gastric banding, Int J Obes Relat Metab Disord, 27, 355, 10.1038/sj.ijo.0802240 Vink, 2017, Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans, Int J Obes (Lond), 41, 309, 10.1038/ijo.2016.201 Johansson, 2012, Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance, Am J Clin Nutr, 96, 196, 10.3945/ajcn.111.020578 Siklova-Vitkova, 2012, Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women, J Clin Endocrinol Metab, 97, E1176, 10.1210/jc.2011-2380 Tchoukalova, 2010, Regional differences in cellular mechanisms of adipose tissue gain with overfeeding, Proc Natl Acad Sci U S A, 107, 18226, 10.1073/pnas.1005259107 Zemel, 2003, Mechanisms of dairy modulation of adiposity, J Nutr, 133, 252S Kershaw, 2004, Adipose tissue as an endocrine organ, J Clin Endocrinol Metab, 89, 2548, 10.1210/jc.2004-0395 Sahin-Efe, 2012, Advances in adipokines, Metabolism, 61, 1659, 10.1016/j.metabol.2012.09.001 Liu, 2003, Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding, J Clin Endocrinol Metab, 88, 5881, 10.1210/jc.2003-030886 Gregor, 2011, Inflammatory mechanisms in obesity, Annu Rev Immunol, 29, 415, 10.1146/annurev-immunol-031210-101322 Bastard, 2006, Recent advances in the relationship between obesity, inflammation, and insulin resistance, Eur Cytokine Netw, 17, 4 Kanda, 2006, MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J Clin Invest, 116, 1494, 10.1172/JCI26498 Hui, 2017, Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, EMBO Rep, 18, 645, 10.15252/embr.201643184 Greenberg, 2006, Obesity and the role of adipose tissue in inflammation and metabolism, Am J Clin Nutr, 83, 461S, 10.1093/ajcn/83.2.461S Wellen, 2005, Inflammation, stress, and diabetes, J Clin Invest, 115, 1111, 10.1172/JCI25102 Ahima, 2000, Leptin, Annu Rev Physiol, 62, 413, 10.1146/annurev.physiol.62.1.413 McConway, 2000, Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans, Ann Clin Biochem, 37, 717, 10.1258/0004563001899771 Friedman, 2002, The function of leptin in nutrition, weight, and physiology, Nutr Rev, 60, S1, 10.1301/002966402320634878 Myers, 2010, Obesity and leptin resistance: distinguishing cause from effect, Trends Endocrinol Metab, 21, 643, 10.1016/j.tem.2010.08.002 Hotamisligil, 1993, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, 259, 87, 10.1126/science.7678183 Koistinen, 2000, Subcutaneous adipose tissue expression of tumour necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects, Eur J Clin Invest, 30, 302, 10.1046/j.1365-2362.2000.00625.x Tanaka, 2014, IL-6 in inflammation, immunity, and disease, Cold Spring Harb Perspect Biol, 6, a016295, 10.1101/cshperspect.a016295 Acosta, 2016, Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes, Diabetologia, 59, 560, 10.1007/s00125-015-3810-6 Carey, 2004, Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness, Diabetologia, 47, 1029, 10.1007/s00125-004-1403-x Okamoto, 2006, Adiponectin: a key adipocytokine in metabolic syndrome, Clin Sci (Lond), 110, 267, 10.1042/CS20050182 Zoico, 2009, The effects of adiponectin on interleukin-6 and MCP-1 secretion in lipopolysaccharide-treated 3T3-L1 adipocytes: role of the NF-kappaB pathway, Int J Mol Med, 24, 847, 10.3892/ijmm_00000302 Yamauchi, 2003, Cloning of adiponectin receptors that mediate antidiabetic metabolic effects, Nature, 423, 762, 10.1038/nature01705 Yamauchi, 2008, Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases, Int J Obes (Lond), 32, S13, 10.1038/ijo.2008.233 Gan, 2015, Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK/ACC2 pathway in chicken adipocyte, J Cell Biochem, 116, 1090, 10.1002/jcb.25064 Jeon, 2012, Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes, Exp Mol Med, 44, 562, 10.3858/emm.2012.44.9.064 Iwabu, 2010, Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1, Nature, 464, 1313, 10.1038/nature08991 Koh, 2007, Essential role of mitochondrial function in adiponectin synthesis in adipocytes, Diabetes, 56, 2973, 10.2337/db07-0510 Ohashi, 2015, Adiponectin as a target in obesity-related inflammatory state, Endocr Metab Immune Disord Drug Targets, 15, 145, 10.2174/1871530315666150316122709 Kadowaki, 2006, Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome, J Clin Invest, 116, 1784, 10.1172/JCI29126 Lihn, 2004, Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects, Mol Cell Endocrinol, 219, 9, 10.1016/j.mce.2004.03.002 Yin, 2014, Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size, J Clin Endocrinol Metab, 99, E209, 10.1210/jc.2013-3042 Kopecky, 2001, Mitochondrial uncoupling and lipid metabolism in adipocytes, Biochem Soc Trans, 29, 791, 10.1042/bst0290791 Wilson-Fritch, 2004, Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone, J Clin Invest, 114, 1281, 10.1172/JCI21752 Pietilainen, 2008, Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity, PLoS Med, 5, e51, 10.1371/journal.pmed.0050051 Dahlman, 2006, Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha, Diabetes, 55, 1792, 10.2337/db05-1421 Villarroya, 2009, Mitochondrial DNA: an up-and-coming actor in white adipose tissue pathophysiology, Obesity (Silver Spring), 17, 1814, 10.1038/oby.2009.152 Choo, 2006, Mitochondria are impaired in the adipocytes of type 2 diabetic mice, Diabetologia, 49, 784, 10.1007/s00125-006-0170-2 Park, 2005, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6, Diabetes Res Clin Pract, 69, 29, 10.1016/j.diabres.2004.11.007 You, 2005, Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors, Am J Physiol Endocrinol Metab, 288, E741, 10.1152/ajpendo.00419.2004 Tilg, 2006, Adipocytokines: mediators linking adipose tissue, inflammation and immunity, Nat Rev Immunol, 6, 772, 10.1038/nri1937 Chudek, 2006, Adipose tissue, inflammation and endothelial dysfunction, Pharmacol Rep, 58, 81 Furukawa, 2004, Increased oxidative stress in obesity and its impact on metabolic syndrome, J Clin Invest, 114, 1752, 10.1172/JCI21625 Tormos, 2011, Mitochondrial complex III ROS regulate adipocyte differentiation, Cell Metab, 14, 537, 10.1016/j.cmet.2011.08.007 Lin, 1999, Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E, J Lipid Res, 40, 1618, 10.1016/S0022-2275(20)33407-6 Lin, 2005, The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species, J Biol Chem, 280, 4617, 10.1074/jbc.M411863200 Bales, 2013, Caloric restriction: implications for human cardiometabolic health, J Cardiopulm Rehabil Prev, 33, 201, 10.1097/HCR.0b013e318295019e Lafontan, 2009, Lipolysis and lipid mobilization in human adipose tissue, Prog Lipid Res, 48, 275, 10.1016/j.plipres.2009.05.001 Grams, 2015, Weight loss and the prevention and treatment of type 2 diabetes using lifestyle therapy, pharmacotherapy, and bariatric surgery: mechanisms of action, Curr Obes Rep, 4, 287, 10.1007/s13679-015-0155-x Sacks, 2009, Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates, N Engl J Med, 360, 859, 10.1056/NEJMoa0804748 de la Iglesia, 2016, Dietary strategies implicated in the prevention and treatment of metabolic syndrome, Int J Mol Sci, 17, 10.3390/ijms17111877 Wing, 2011, Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes, Diabetes Care, 34, 1481, 10.2337/dc10-2415 Rossmeislova, 2013, Adaptation of human adipose tissue to hypocaloric diet, Int J Obes (Lond), 37, 640, 10.1038/ijo.2012.80 Joris, 2017, Diet-induced weight loss improves not only cardiometabolic risk markers but also markers of vascular function: a randomized controlled trial in abdominally obese men, Am J Clin Nutr, 105, 23, 10.3945/ajcn.116.143552 Summer, 2011, Adiponectin changes in relation to the macronutrient composition of a weight-loss diet, Obesity (Silver Spring), 19, 2198, 10.1038/oby.2011.60 Christiansen, 2005, Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects, Int J Obes (Lond), 29, 146, 10.1038/sj.ijo.0802839 Bouche, 2002, Five-week, low-glycemic index diet decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men, Diabetes Care, 25, 822, 10.2337/diacare.25.5.822 Qi, 2006, Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women, Diabetes Care, 29, 207, 10.2337/diacare.29.02.06.dc05-1903 de Mello, 2008, Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study, Diabetologia, 51, 2060, 10.1007/s00125-008-1132-7 Gredilla, 2005, Minireview: the role of oxidative stress in relation to caloric restriction and longevity, Endocrinology, 146, 3713, 10.1210/en.2005-0378 Steckhan, 2016, Effects of different dietary approaches on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis, Nutrition, 32, 338, 10.1016/j.nut.2015.09.010 Stern, 2004, The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial, Ann Intern Med, 140, 778, 10.7326/0003-4819-140-10-200405180-00007 Ellsworth, 2015, Importance of substantial weight loss for altering gene expression during cardiovascular lifestyle modification, Obesity (Silver Spring), 23, 1312, 10.1002/oby.21079 Forsythe, 2008, Obesity and inflammation: the effects of weight loss, Nutr Res Rev, 21, 117, 10.1017/S0954422408138732 Selvin, 2007, The effect of weight loss on C-reactive protein: a systematic review, Arch Intern Med, 167, 31, 10.1001/archinte.167.1.31 Capel, 2009, Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization, Diabetes, 58, 1558, 10.2337/db09-0033 Labonte, 2014, Dairy product consumption has no impact on biomarkers of inflammation among men and women with low-grade systemic inflammation, J Nutr, 144, 1760 Katzmarzyk, 2003, Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study, Med Sci Sports Exerc, 35, 1703, 10.1249/01.MSS.0000089337.73244.9B Lindstrom, 2006, Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study, Lancet, 368, 1673, 10.1016/S0140-6736(06)69701-8 Christiansen, 2010, Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study, Am J Physiol Endocrinol Metab, 298, E824, 10.1152/ajpendo.00574.2009 Muoio, 2012, Lipid-induced mitochondrial stress and insulin action in muscle, Cell Metab, 15, 595, 10.1016/j.cmet.2012.04.010 Santos, 1991, Effect of anatomical site on insulin action and insulin receptor phosphorylation in isolated rat adipocytes, Int J Obes, 15, 755 Portillo, 2000, In vivo lipolysis in adipose tissue from two anatomical locations measured by microdialysis, Life Sci, 67, 437, 10.1016/S0024-3205(00)00642-1 Marin, 2017, AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1, Sci Signal, 10, 10.1126/scisignal.aaf7478 De Pauw, 2009, Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations, Am J Pathol, 175, 927, 10.2353/ajpath.2009.081155 Stallknecht, 1991, Increased activities of mitochondrial enzymes in white adipose tissue in trained rats, Am J Physiol, 261, E410 Steinberg, 2007, The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity, Mini Rev Med Chem, 7, 519, 10.2174/138955707780619662 Sponarova, 2005, Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation, FEBS Lett, 579, 6105, 10.1016/j.febslet.2005.09.078 Ruderman, 2003, AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise, Acta Physiol Scand, 178, 435, 10.1046/j.1365-201X.2003.01164.x List, 2013, The effects of weight cycling on lifespan in male C57BL/6J mice, Int J Obes (Lond), 37, 1088, 10.1038/ijo.2012.203 Benton, 2008, PGC-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions, Appl Physiol Nutr Metab, 33, 843, 10.1139/H08-074 Scarpulla, 2011, Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network, Biochim Biophys Acta, 1813, 1269, 10.1016/j.bbamcr.2010.09.019 Chaube, 2015, AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1alpha-mediated mitochondrial biogenesis, Cell Death Discov, 1, 15063, 10.1038/cddiscovery.2015.63 Canto, 2011, Calorie restriction: is AMPK a key sensor and effector?, Physiology (Bethesda), 26, 214 Cohen, 2004, Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase, Science, 305, 390, 10.1126/science.1099196 Gerhart-Hines, 2007, Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha, EMBO J, 26, 1913, 10.1038/sj.emboj.7601633 Price, 2012, SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function, Cell Metab, 15, 675, 10.1016/j.cmet.2012.04.003 Klemsdal, 2010, Effects of a low glycemic load diet versus a low-fat diet in subjects with and without the metabolic syndrome, Nutr Metab Cardiovasc Dis, 20, 195, 10.1016/j.numecd.2009.03.010 Simpson, 2015, Putting the balance back in diet, Cell, 161, 18, 10.1016/j.cell.2015.02.033 Bach-Faig, 2011, Mediterranean diet pyramid today. Science and cultural updates, Public Health Nutr, 14, 2274, 10.1017/S1368980011002515 Middleton, 2015, Brief report: implementing a mediterranean diet intervention into a RCT: lessons learned from a non-mediterranean based Country, J Nutr Health Aging, 19, 1019, 10.1007/s12603-015-0663-0 Solon-Biet, 2015, Macronutrient balance, reproductive function, and lifespan in aging mice, Proc Natl Acad Sci USA, 112, 3481, 10.1073/pnas.1422041112 Solon-Biet, 2015, Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice, Cell Rep, 11, 1529, 10.1016/j.celrep.2015.05.007 Newgard, 2012, Interplay between lipids and branched-chain amino acids in development of insulin resistance, Cell Metab, 15, 606, 10.1016/j.cmet.2012.01.024 Rizkalla, 2012, Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial, Am J Clin Nutr, 95, 49, 10.3945/ajcn.111.017277 Dong, 2012, Meta-analysis of dietary glycemic load and glycemic index in relation to risk of coronary heart disease, Am J Cardiol, 109, 1608, 10.1016/j.amjcard.2012.01.385 Fan, 2012, Dietary glycemic index, glycemic load, and risk of coronary heart disease, stroke, and stroke mortality: a systematic review with meta-analysis, PLoS One, 7, e52182, 10.1371/journal.pone.0052182 Costantino, 2015, Hyperglycemia: a bad signature on the vascular system, Cardiovasc Diagn Ther, 5, 403 Tay, 2017, Effects of an energy-restricted low-carbohydrate, high unsaturated fat/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: a 2-year randomized clinical trial, Diabetes Obes Metab, 4, 858 Jenkins, 2002, Glycemic index: overview of implications in health and disease, Am J Clin Nutr, 76, 266S, 10.1093/ajcn/76.1.266S Barclay, 2008, Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies, Am J Clin Nutr, 87, 627, 10.1093/ajcn/87.3.627 Kristo, 2013, Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials, Nutrients, 5, 1071, 10.3390/nu5041071 Hartman, 2010, Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer, J Nutr, 140, 60 Raatz, 2005, Reduced glycemic index and glycemic load diets do not increase the effects of energy restriction on weight loss and insulin sensitivity in obese men and women, J Nutr, 135, 2387 Stimson, 2007, Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men, J Clin Endocrinol Metab, 92, 4480, 10.1210/jc.2007-0692 Zheng, 2015, Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy, Biochim Biophys Acta, 1852, 332, 10.1016/j.bbadis.2014.04.023 Choi, 2015, Br J Nutr, 113, 867, 10.1017/S0007114515000100 Bullen, 2007, Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice, Am J Physiol Endocrinol Metab, 292, E1079, 10.1152/ajpendo.00245.2006 Ramos-Ramirez, 2016, Weight gain alters adiponectin receptor 1 expression on adipose tissue-resident Helios+ regulatory T cells, Scand J Immunol, 83, 244, 10.1111/sji.12419 Barnea, 2006, A high-fat diet has a tissue-specific effect on adiponectin and related enzyme expression, Obesity (Silver Spring), 14, 2145, 10.1038/oby.2006.251 Caughey, 1996, The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil, Am J Clin Nutr, 63, 116, 10.1093/ajcn/63.1.116 Itariu, 2012, Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial, Am J Clin Nutr, 96, 1137, 10.3945/ajcn.112.037432 Telle-Hansen, 2017, Does dietary fat affect inflammatory markers in overweight and obese individuals?-a review of randomized controlled trials from 2010 to 2016, Genes Nutr, 12, 26, 10.1186/s12263-017-0580-4 Calder, 2003, N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic, Lipids, 38, 343, 10.1007/s11745-003-1068-y Serhan, 2004, Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers, Lipids, 39, 1125, 10.1007/s11745-004-1339-7 Lin, 2016, What is the impact of n-3 PUFAs on inflammation markers in Type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials, Lipids Health Dis, 15, 133, 10.1186/s12944-016-0303-7 Klein-Platat, 2005, Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents, Am J Clin Nutr, 82, 1178, 10.1093/ajcn/82.6.1178 Jia, 2007, Autophagy is required for dietary restriction-mediated life span extension in C. elegans, Autophagy, 3, 597, 10.4161/auto.4989 Ajala, 2013, Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes, Am J Clin Nutr, 97, 505, 10.3945/ajcn.112.042457 Fontana, 2007, Aging, adiposity, and calorie restriction, JAMA, 297, 986, 10.1001/jama.297.9.986 Paquot, 2000, No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients, J Clin Endocrinol Metab, 85, 1316 Ofei, 1996, Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM, Diabetes, 45, 881, 10.2337/diab.45.7.881 Richard, 2014, Effect of Mediterranean diet with and without weight loss on apolipoprotein B100 metabolism in men with metabolic syndrome, Arterioscler Thromb Vasc Biol., 34, 433, 10.1161/ATVBAHA.113.302185 Jonasson, 2014, Advice to follow a low-carbohydrate diet has a favourable impact on low-grade inflammation in type 2 diabetes compared with advice to follow a low-fat diet, Ann Med, 46, 182, 10.3109/07853890.2014.894286 Clifton, 2005, Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets, Int J Obes (Lond), 29, 1445, 10.1038/sj.ijo.0803039