Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics

Georg Juckel1,2, Florian Schlagenhauf2, Michael Koslowski2, Dimitri Filonov2, Torsten Wüstenberg3,4, Arno Villringer4, Brian Knutson5, Thorsten Kienast2, Jürgen Gallinat2, Jana Wrase2, Andreas Heinz2
1Department of Psychiatry, Ruhr-University Bochum, Bochum, Germany
2Department of Psychiatry, Charité University Medical Center, Berlin, Germany
3Department of Medical Psychology, Georg August University, Göttingen, Germany
4Department of Neurology, Charité University Medical Center, Berlin, Germany
5Department of Psychology, Stanford University, Stanford, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Akhondzadeh S (2001) The 5-HT hypothesis of schizophrenia. IDrugs 4:295–300

Andreasen NC (1990) Positive and negative symptoms: historical and conceptual aspects. Mod Probl Pharmacopsychiatry 24:1–42

Bertolino A, Caforio G, Blasi G, De CM, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M (2004) Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am J Psychiatry 161:1798–1805

Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P (2001) Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30:619–639

Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR (2003) Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry 160:2209–2215

Cohen MS (1997) Parametric analysis of fMRI data using linear systems methods. Neuroimage 6:93–103

Crespo-Facorro B, Paradiso S, Andreasen NC, O’Leary DS, Watkins GL, Ponto LL, Hichwa RD (2001) Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors. JAMA 286:427–435

de Haan L, Lavalaye J, van BM, van NL, Booij J, van AT, Linszen D (2004) Subjective experience and dopamine D2 receptor occupancy in patients treated with antipsychotics: clinical implications. Can J Psychiatry 49:290–296

Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G (1992) Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 49:538–544

First MB, Spitzer RL, Gibbon M, Williams J (2001) Structured Clinical Interview for DSM-IV-TR axis I disorders, research version, patient edition with Psychotic Screen (SCID-I/P W/ PSY SCREEN). New York State Psychiatric Institute, New York

Fox PT, Lancaster JL (2002) Opinion: mapping context and content: the BrainMap model. Nat Rev Neurosci 3:319–321

Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ (1995) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 2:189–210

Glick ID, Lemmens P, Vester-Blokland E (2001) Treatment of the symptoms of schizophrenia: a combined analysis of double-blind studies comparing risperidone with haloperidol and other antipsychotic agents. Int Clin Psychopharmacol 16:265–274

Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159:1642–1652

Heinz A, Knable MB, Coppola R, Gorey JG, Jones DW, Lee KS, Weinberger DR (1998) Psychomotor slowing, negative symptoms and dopamine receptor availability—an IBZM SPECT study in neuroleptic-treated and drug-free schizophrenic patients. Schizophr Res 31:19–26

Honey GD, Bullmore ET, Soni W, Varatheesan M, Williams SC, Sharma T (1999) Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proc Natl Acad Sci U S A 96:13432–13437

Juckel G, Schlagenhauf F, Koslowski M, Wustenberg T, Villringer A, Knutson B, Wrase J, Heinz A (2006) Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 29:409–416

Kapur S, Seeman P (2001) Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics? A new hypothesis. Am J Psychiatry 158:360–369

Kapur S, Barsoum SC, Seeman P (2000) Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology 23:595–598

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276

Knutson B, Adams CM, Fong GW, Hommer D (2001) Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21:RC159

Meltzer HY, Li Z, Kaneda Y, Ichikawa J (2003) Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 27:1159–1172

Nielsen FA, Hansen LA (2002) Automatic anatomical labeling of Talairach coordinates and generation of volumes of interest via the BrainMap database. Neuroimage 16(2)

Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113

Prosser ES, Csernansky JG, Kaplan J, Thiemann S, Becker TJ, Hollister LE (1987) Depression, parkinsonian symptoms, and negative symptoms in schizophrenics treated with neuroleptics. J Nerv Ment Dis 175:100–105

Sawa A, Snyder SH (2003) Schizophrenia: neural mechanisms for novel therapies. Mol Med 9:3–9

Wise RA (1982) Neuroleptics and operant-behavior—the anhedonia hypothesis. Behav Brain Sci 5:39–53