Defensins of vertebrate animals

Current Opinion in Immunology - Tập 14 - Trang 96-102 - 2002
Robert I Lehrer1, Tomas Ganz2
1Department of Medicine (Room CHS 37-062), Molecular Biology Institute University of California at Los Angeles (UCLA) Center for the Health Sciences, Los Angeles, CA 90095, USA
2Department of Medicine (Room CHS 37-062), Department of Pathology, University of California at Los Angeles (UCLA) Center for the Health Sciences, Los Angeles, CA 90095, USA

Tài liệu tham khảo

Zeya, 1966, Cationic proteins of polymorphonuclear leukocyte lysosomes. II. Composition, properties, and mechanism of antibacterial action, J. Bacteriol., 91, 755, 10.1128/JB.91.2.755-762.1966 Zeya, 1966, Cationic proteins of polymorphonuclear leukocyte lysosomes. I. Resolution of antibacterial and enzymatic activities, J. Bacteriol., 91, 750, 10.1128/JB.91.2.750-754.1966 Ouellette, 2001, Paneth cell defensins and innate immunity of the small bowel, Inflam. Bowel. Dis., 7, 43, 10.1097/00054725-200102000-00007 Tang, 1999, A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins, Science, 286, 498, 10.1126/science.286.5439.498 Otvos, 2000, Antibacterial peptides isolated from insects, J. Pept. Sci., 6, 497, 10.1002/1099-1387(200010)6:10<497::AID-PSC277>3.0.CO;2-W Garcia-Olmedo, 1998, Plant defense peptides, Biopolymers, 47, 479, 10.1002/(SICI)1097-0282(1998)47:6<479::AID-BIP6>3.0.CO;2-K Schroder, 1999, Human β-defensin-2, Int. J. Biochem. Cell. Biol., 31, 645, 10.1016/S1357-2725(99)00013-8 Sawai, 2001, The NMR structure of human β-defensin-2 reveals a novel α-helical segment, Biochemistry, 40, 3810, 10.1021/bi002519d Hoover, 2000, The structure of human β-defensin-2 shows evidence of higher order oligomerization, J. Biol. Chem., 275, 32911, 10.1074/jbc.M006098200 Zimmermann, 1995, Solution structure of bovine neutrophil β-defensin-12: the peptide fold of the β-defensins is identical to that of the classical defensins, Biochemistry, 34, 13663, 10.1021/bi00041a048 Hoover, 2001, The structure of human β defensin-1. New insights into structural properties of β-defensins, J. Biol. Chem., 276, 39021, 10.1074/jbc.M103830200 Torres, 2000, Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold, Biochem. J., 348, 649, 10.1042/0264-6021:3480649 Harder, 2001, Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic, J. Biol. Chem., 276, 5707, 10.1074/jbc.M008557200 Garcia, 2001, Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity, FASEB. J., 15, 1819, 10.1096/fj.00-0865fje Frohlich, 2001, Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes, Biol. Reprod., 64, 1072, 10.1095/biolreprod64.4.1072 Jia, 2001, Discovery of new human β-defensins using a genomics-based approach, Gene, 263, 211, 10.1016/S0378-1119(00)00569-2 Li, 2001, An antimicrobial peptide gene found in the male reproductive system of rats, Science, 291, 1783, 10.1126/science.1056545 Yamaguchi, 2001, A novel mouse β-defensin, mBD-6, predominantly expressed in skeletal muscle, J. Biol. Chem., 276, 31510, 10.1074/jbc.M104149200 Morrison, 1999, A novel mouse β defensin, Defb2, which is upregulated in the airways by lipopolysaccharide, FEBS. Lett., 442, 112, 10.1016/S0014-5793(98)01630-5 Morrison, 1998, Mouse β defensin-1 is a functional homolog of human β defensin-1, Mamm. Genome., 9, 453, 10.1007/s003359900795 Bals, 1999, Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs, Infect. Immun., 67, 3542, 10.1128/IAI.67.7.3542-3547.1999 Jia, 2000, A novel murine β-defensin expressed in tongue, esophagus, and trachea, J. Biol. Chem., 275, 33314, 10.1074/jbc.M006603200 Shi, 1999, Porcine epithelial β-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations, Infect. Immun., 67, 3121, 10.1128/IAI.67.6.3121-3127.1999 Tam, 1999, An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides, Proc. Natl. Acad. Sci. USA., 96, 8913, 10.1073/pnas.96.16.8913 Leonova, 2001, Circular minidefensins and posttranslational generation of molecular diversity, J. Leukoc. Biol., 70, 461, 10.1189/jlb.70.3.461 Valore, 1992, Posttranslational processing of defensins in immature human myeloid cells, Blood, 79, 1538, 10.1182/blood.V79.6.1538.1538 Lopez-Boado, 2000, Bacterial exposure induces and activates matrilysin in mucosal epithelial cells, J. Cell. Biol., 148, 1305, 10.1083/jcb.148.6.1305 Wilson, 1999, Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense, Science, 286, 113, 10.1126/science.286.5437.113 Putsep, 2000, Germ-free and colonized mice generate the same products from enteric prodefensins, J. Biol. Chem., 275, 40478, 10.1074/jbc.M007816200 Tunzi, 2000, β-defensin expression in human mammary gland epithelia, Pediatr. Res., 48, 30, 10.1203/00006450-200007000-00008 Jia, 2001, Abundant human β-defensin-1 expression in milk and mammary gland epithelium, J. Pediatr., 138, 109, 10.1067/mpd.2001.109375 Duits, 2001, Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids, Biochem. Biophys. Res. Commun., 280, 522, 10.1006/bbrc.2000.4157 Becker, 2000, CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium, J. Biol. Chem., 275, 29731, 10.1074/jbc.M000184200 Fehlbaum, 2000, An essential amino acid induces epithelial β-defensin expression, Proc. Natl. Acad. Sci. USA., 97, 12723, 10.1073/pnas.220424597 Tani, 2000, Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens, Int. Immunol., 12, 691, 10.1093/intimm/12.5.691 Eisenhauer, 1992, Mouse neutrophils lack defensins, Infect. Immun., 60, 3446, 10.1128/IAI.60.8.3446-3447.1992 Agerberth, 2000, The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations, Blood, 96, 3086, 10.1182/blood.V96.9.3086 Yang, 2000, Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells, J. Leukoc. Biol., 68, 9, 10.1189/jlb.68.1.9 Yang, 1999, β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6, Science, 286, 525, 10.1126/science.286.5439.525 Chaly, 2000, Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells, Eur. Cytokine. Netw., 11, 257 Peschel, 1999, Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides, J. Biol. Chem., 274, 8405, 10.1074/jbc.274.13.8405 Peschel, 2001, Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine, J. Exp. Med., 193, 1067, 10.1084/jem.193.9.1067 Schmidtchen, 2001, Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial α-defensin, Mol. Microbiol., 39, 708, 10.1046/j.1365-2958.2001.02251.x Cole, 2001, IFN-inducible ELR–CXC chemokines display defensin-like antimicrobial activity, J. Immunol., 167, 623, 10.4049/jimmunol.167.2.623 Perez-Canadillas, 2001, NMR solution structure of murine CCL20/MIP-3α, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the β-chemokine receptor CCR6, J. Biol. Chem., 276, 28372, 10.1074/jbc.M103121200 McManus, 2000, Three-dimensional structure of RK-1: a novel α-defensin peptide, Biochemistry, 39, 15757, 10.1021/bi000457l Lencer, 1997, Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3, Proc. Natl. Acad. Sci. USA., 94, 8585, 10.1073/pnas.94.16.8585 Hiratsuka, 2000, Structural analysis of human β-defensin-1 and its significance in urinary tract infection, Nephron, 85, 34, 10.1159/000045627 Zhao, 2001, Gallinacin-3, an inducible epithelial β-defensin in the chicken, Infect. Immun., 69, 2684, 10.1128/IAI.69.4.2684-2691.2001 Perler, 1997, Protein splicing and autoproteolysis mechanisms, Curr. Opin. Chem. Biol., 1, 292, 10.1016/S1367-5931(97)80065-8 Ayabe, 2000, Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria, Nat. Immunol., 1, 113, 10.1038/77783 Cole, 2001, Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds, Blood, 97, 297, 10.1182/blood.V97.1.297