The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

Glomset, 1968, The plasma lecithins: cholesterol acyltransferase reaction, J Lipid Res, 9, 155, 10.1016/S0022-2275(20)43114-1 von Eckardstein, 2001, High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport, Arterioscler Thromb Vasc Biol, 21, 13, 10.1161/01.ATV.21.1.13 Higgins, 1992, ABC transporters: from microorganisms to man, Annu Rev Cell Biol, 8, 67, 10.1146/annurev.cb.08.110192.000435 van Eck, 2002, Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues, Proc Natl Acad Sci USA, 99, 6298, 10.1073/pnas.092327399 Aiello, 2002, Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages, Arterioscler Thromb Vasc Biol, 22, 630, 10.1161/01.ATV.0000014804.35824.DA Oram, 2000, ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages, J Biol Chem, 275, 34508, 10.1074/jbc.M006738200 Wang, 2004, ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins, Proc Natl Acad Sci USA, 101, 9774, 10.1073/pnas.0403506101 Kennedy, 2005, ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation, Cell Metab, 1, 121, 10.1016/j.cmet.2005.01.002 Out, 2006, Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice, Arterioscler Thromb Vasc Biol, 26, 2295, 10.1161/01.ATV.0000237629.29842.4c Out, 2007, Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arterioscler Thromb Vasc Biol, 27, 594, 10.1161/01.ATV.0000257136.24308.0c Out, 2008, Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels, Arterioscler Thromb Vasc Biol, 28, 258, 10.1161/ATVBAHA.107.156935 Lammers, 2009, Independent protective roles for macrophage Abcg1 and ApoE in the atherosclerotic lesion development, Atherosclerosis, 10.1016/j.atherosclerosis.2009.01.017 Baldan, 2006, Impaired development of atherosclerosis in hyperlipidemic Ldlr−/− and ApoE−/− mice transplanted with Abcg1−/− bone marrow, Arterioscler Thromb Vasc Biol, 26, 2301, 10.1161/01.ATV.0000240051.22944.dc Tarling, 2010, Impaired development of atherosclerosis in Abcg1−/− ApoE−/− mice: identification of specific oxysterols that both accumulate in Abcg1−/− ApoE−/− tissues and induce apoptosis, Arterioscler Thromb Vasc Biol, 30, 1174, 10.1161/ATVBAHA.110.205617 Ranalletta, 2006, Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1−/− bone marrow, Arterioscler Thromb Vasc Biol, 26, 2308, 10.1161/01.ATV.0000242275.92915.43 Mendez, 1997, Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion, J Lipid Res, 38, 1807, 10.1016/S0022-2275(20)37155-8 Duong, 2006, Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages, Arterioscler Thromb Vasc Biol, 26, 541, 10.1161/01.ATV.0000203515.25574.19 Babiker, 1997, Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport, J Biol Chem, 272, 26253, 10.1074/jbc.272.42.26253 Klucken, 2000, ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport, Proc Natl Acad Sci USA, 97, 817, 10.1073/pnas.97.2.817 Baldan, 2008, Loss of ABCG1 results in chronic pulmonary inflammation, J Immunol, 180, 3560, 10.4049/jimmunol.180.5.3560 Baldan, 2006, Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis, J Biol Chem, 281, 29401, 10.1074/jbc.M606597200 Wojcik, 2008, A critical role for ABCG1 in macrophage inflammation and lung homeostasis, J Immunol, 180, 4273, 10.4049/jimmunol.180.6.4273 Yvan-Charvet, 2007, Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice, J Clin Invest, 117, 3900 Burgess, 2008, Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice, Arterioscler Thromb Vasc Biol, 28, 1731, 10.1161/ATVBAHA.108.168542 Basso, 2006, Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet, Biochem Biophys Res Commun, 351, 398, 10.1016/j.bbrc.2006.10.044 Westerterp, 2010, Increased atherosclerosis in mice with vascular ATP-binding cassette transporter G1 deficiency—brief report, Arterioscler Thromb Vasc Biol, 30, 2103, 10.1161/ATVBAHA.110.212985 Kockx, 1998, Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects, Arterioscler Thromb Vasc Biol, 18, 1519, 10.1161/01.ATV.18.10.1519 Arai, 2005, A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development, Cell Metab, 1, 201, 10.1016/j.cmet.2005.02.002 Liu, 2005, Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice, Arterioscler Thromb Vasc Biol, 25, 174, 10.1161/01.ATV.0000148548.47755.22 Schrijvers, 2005, Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis, Arterioscler Thromb Vasc Biol, 25, 1256, 10.1161/01.ATV.0000166517.18801.a7 Henson, 2001, Apoptotic cell removal, Curr Biol, 11, R795, 10.1016/S0960-9822(01)00474-2 Majno, 1995, Apoptosis, oncosis, and necrosis: an overview of cell death, Am J Pathol, 146, 3 Tabas, 1996, J Biol Chem, 271, 22773, 10.1074/jbc.271.37.22773 Warner, 1995, Cell toxicity induced by inhibition of acyl coenzyme A: cholesterol acyltransferase and accumulation of unesterified cholesterol, J Biol Chem, 270, 5772, 10.1074/jbc.270.11.5772 Terasaka, 2007, High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1, Proc Natl Acad Sci USA, 104, 15093, 10.1073/pnas.0704602104