Molecular signaling pathways that regulate prostate gland development
Tài liệu tham khảo
Bardin, 1973, Androgen metabolism and mechanism of action in male pseudohermaphroditism: a study of testicular feminization, Rec Prog Horm Res, 29, 65
Barnett, 2002, The human prostate expresses sonic hedgehog during fetal development, J Urol, 168, 2206, 10.1016/S0022-5347(05)64356-X
Bejsovec, 2005, Wnt pathway activation: new relations and locations, Cell, 120, 11
Bellusci, 1997, Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung, Development, 124, 4867, 10.1242/dev.124.23.4867
Berman, 2004, Roles for hedgehog signaling in androgen production and prostate ductal morphogenesis, Dev Biol, 267, 387, 10.1016/j.ydbio.2003.11.018
Bethel, 2006, Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion, Cancer Res, 66, 10683, 10.1158/0008-5472.CAN-06-0963
Bhatia-Gaur, 1999, Roles for Nkx3.1 in prostate development and cancer, Gen Dev, 13, 966, 10.1101/gad.13.8.966
Bieberich, 1996, Prostate-specific and androgen-dependent expression of a novel homeobox gene, J Biol Chem, 271, 31779, 10.1074/jbc.271.50.31779
Bierie, 2003, Activation of b-catenin in prostate epithelium induces hyperplasia and squamous transdifferentiation, Oncogene, 22, 3875, 10.1038/sj.onc.1206426
Bolos, 2007, Notch signaling in development and cancer, Endocrine Rev, 28, 339, 10.1210/er.2006-0046
Bowen, 2000, Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression, Cancer Res, 60, 6111
Brown, 1995, Human androgen insensitivity syndrome, J Androl, 16, 299
Cadigan, 1997, Wnt signaling: a common theme in animal development, Genes Dev, 11, 3286, 10.1101/gad.11.24.3286
Cancilla, 2001, Regulation of prostate branching morphogenesis by Activin A and Follistatin, Dev Biol, 237, 145, 10.1006/dbio.2001.0364
Chang, 1999, Neonatal estrogen exposure alters the transforming growth factor-β signaling system in the developing rat prostate and blocks the transient p21cip1/wafl expression associated with epithelial differentiation, Endocrinology, 140, 2801, 10.1210/endo.140.6.6833
Chang, 1999, Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate, Endocrinology, 140, 405, 10.1210/endo.140.1.6401
Chen, 2005, Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1, Dev Dyn, 234, 961, 10.1002/dvdy.20596
Chesire, 2002, In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis, Oncogene, 21, 2679, 10.1038/sj.onc.1205352
Chesire, 2003, Beta-catenin signaling in prostate cancer: an early perspective, Endocrine Related Cancers, 10, 537, 10.1677/erc.0.0100537
Chuang, 2003, Branching morphogenesis of the lung: new molecular insights into an old problem, Trends Cell Biol, 13, 86, 10.1016/S0962-8924(02)00031-4
Clevidence, 1993, Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family, Proc Natl Acad Sci USA, 90, 3948, 10.1073/pnas.90.9.3948
Committee, 1999, A unified nomenclature system for the nuclear receptor superfamily, Cell, 97, 161, 10.1016/S0092-8674(00)80726-6
Cook, 2007, Noggin is required for normal lobe patterning and ductal budding in the mouse prostate, Dev Biol, 312, 217, 10.1016/j.ydbio.2007.09.038
Cunha, 1973, The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice, Anat Rec, 175, 87, 10.1002/ar.1091750108
Cunha, 1992, Role of epithelial-mesenchymal interactions in the differentiation and spatial organization of visceral smooth muscle, Epithelial Cell Biol, 1, 76
Cunha, 1981, Stromal-epithelial interactions: I. Induction of prostatic phenotype in urothelium of testicular feminized (Tfm/Y) mice, J Steroid Biochem, 14, 1317, 10.1016/0022-4731(81)90338-1
Cunha, 1987, The endocrinology and developmental biology of the prostate, Endo Rev, 8, 338, 10.1210/edrv-8-3-338
Doles, 2006, Functional compensation in hedgehog signaling during mouse prostate development, Dev Biol, 295, 13, 10.1016/j.ydbio.2005.12.002
Donjacour, 1993, Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice, Endocrinology, 132, 2342, 10.1210/endo.132.6.7684975
Donjacour, 2003, FGF-10 plays an essential role in the growth of the fetal prostate, Dev Biol, 261, 39, 10.1016/S0012-1606(03)00250-1
Economides, 2003, Hoxb13 is required for normal differentiation and secretory function of the ventral prostate, Development, 130, 2061, 10.1242/dev.00432
Edwards, 2005, Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer, Br J Cancer, 92, 376, 10.1038/sj.bjc.6602261
Fang, 1969, Receptor proteins for androgens, J Biochem, 244, 6584
Finch, 1995, Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions, Dev Dyn, 203, 223, 10.1002/aja.1002030210
Foster, 1999, Efficacy of various natural and synthetic androgens to induce ductal branching morphogenesis in the developing anterior rat prostate, Endocrinology, 140, 318, 10.1210/endo.140.1.6435
Freestone, 2003, Sonic hedgehog regulates prostatic growth and epithelial differentiation, Dev Biol, 264, 352, 10.1016/j.ydbio.2003.08.018
Fritzsche, 2006, Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma, Endocrine Related Cancer, 13, 839, 10.1677/erc.1.01190
Gao, 2005, Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation, Development, 132, 4331, 10.1242/dev.01917
Gehring, 1994, The discovery of the homeobox, 3
Gerdes, 1998, Transforming growth factor-β1 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle ells, Endocrinology, 139, 3569, 10.1210/endo.139.8.6138
Goyette, 2000, Regulation of Gli activity by all-trans retinoic acid in mouse keratinocytes, Cancer Res, 60, 5386
Grishina, 2005, BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling, Dev Biol, 288, 334, 10.1016/j.ydbio.2005.08.018
Gritli-Linde, 2001, The whereabouts of a morphogen: direct evidence for short-and graded long-range activity of hedgehog signaling peptides, Dev Biol, 236, 364, 10.1006/dbio.2001.0336
Guan, 2007, Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1, J Biol Chem, 283, 4834, 10.1074/jbc.M708630200
Haraguchi, 2001, Unique functions of sonic hedgehog signaling during external genitalia development, Development, 128, 4241, 10.1242/dev.128.21.4241
Hayashi, 1991, Morphological and functional heterogeneity in the rat prostatic gland, Biol Reprod, 45, 308, 10.1095/biolreprod45.2.308
Hayward, 1996, Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat, Acta Anat, 155, 94, 10.1159/000147794
Hayward, 1996, Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle, Acta Anat, 155, 81, 10.1159/000147793
Hogan, 1996, Bone morphogenetic proteins in development, Curr Opin Gen Dev, 6, 432, 10.1016/S0959-437X(96)80064-5
Hogan, 1999, Morphogenesis, Cell, 96, 225, 10.1016/S0092-8674(00)80562-0
Hsieh, 1999, A new secreted protein that binds to Wnt proteins and inhibits their activities, Nature, 398, 431, 10.1038/18899
Huang, 2004, Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development, J Androl, 25, 330, 10.1002/j.1939-4640.2004.tb02796.x
Huang, 2005, The role of Fgf10 signaling in branching morphogenesis and gene expression in the rat prostate gland: lobe-specific supression by neonatal estrogens, Dev Biol, 278, 396, 10.1016/j.ydbio.2004.11.020
Huang, 2006, Wnt5a is required for prostate morphogenesis, J Androl, 27, 85
Huang, 2007, Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes, Endocrinology, 148, 1235, 10.1210/en.2006-1250
Husmann, 1991, Androgen receptor expression in the developing rat prostate is not altered by castration, flutamide, or suppression of the adrenal axis, Endocrinology, 128, 1902, 10.1210/endo-128-4-1902
Ingham, 2001, Review: hedgehog signaling in animal development: paradigms and principles, Genes Dev, 15, 3059, 10.1101/gad.938601
Itoh, 1998, Developmental and hormonal regulation of transforming growth factor-β1 (TGF β1), -2, and -3 gene expression in isolated prostatic epithelial and stromal cells: epidermal growth factor and TGFβ interactions, Endocrinology, 139, 1378, 10.1210/endo.139.3.5787
Joesting, 2005, Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer, Cancer Res, 65, 10423, 10.1158/0008-5472.CAN-05-0824
Jost, 1953, Problems of fetal endocrinology: the gonadal and hypophyseal hormones, Rec Prog Horm Res, 8, 379
Jung, 2004, HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4, Cancer Res, 64, 3046, 10.1158/0008-5472.CAN-03-2614
Jung, 2004, HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling, Cancer Res, 64, 9185, 10.1158/0008-5472.CAN-04-1330
Kaestner, 2000, Unified nomenclature for the winged helix/forkhead transcription factors, Genes Dev, 14, 142, 10.1101/gad.14.2.142
Kim, 2002, Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis, Cancer Res, 62, 2999
Kopachik, 1998, Expression of hepatocyte nuclear factor-3α in rat prostate, seminal vesicle, and bladder, Dev Dyn, 211, 131, 10.1002/(SICI)1097-0177(199802)211:2<131::AID-AJA2>3.0.CO;2-I
Krumlauf, 1994, Hox genes in vertebrate development, Cell, 78, 191, 10.1016/0092-8674(94)90290-9
Kuslak, 2007, Fibroblast growth factor receptor signaling through MEK-ERK is required for prostate bud induction, Differentiation, 75, 638, 10.1111/j.1432-0436.2006.00161.x
Lamm, 2002, Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation, Dev Biol, 249, 349, 10.1006/dbio.2002.0774
Lamm, 2001, Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate, Dev Biol, 232, 301, 10.1006/dbio.2001.0187
Lasnitzki, 1977, Induction of the rat prostate gland by androgens in organ culture, J Endocrinol, 74, 47, 10.1677/joe.0.0740047
Lee, 1990, Prostatic ductal system in rats: regional variation in morphological and functional activities, Biol Reprod, 43, 1079, 10.1095/biolreprod43.6.1079
Liao, 1969, Receptor-proteins for androgens and the mode of action of androgens on gene transcription in ventral prostate, Vitamins and Hormones, 27, 17, 10.1016/S0083-6729(08)61124-3
Lin, 2007, Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis, Development, 134, 723, 10.1242/dev.02765
Lipschutz, 1997, Differentiation of rat neonatal ventral prostates grown in a serum-free organ culture system, Prostate, 32, 35, 10.1002/(SICI)1097-0045(19970615)32:1<35::AID-PROS5>3.0.CO;2-B
Lowsley, 1912, The development of the human prostate gland with reference to the development of other structures at the neck of the urinary bladder, Am J Anat, 13, 299, 10.1002/aja.1000130303
Lu, 1999, Fibroblast growth factor-10: a second candidate stromal to epithelial cell andromedin in prostate, J Biol Chem, 274, 12827, 10.1074/jbc.274.18.12827
Mao, 2001, LDL-receptor-related protein 6 is a receptor for Dickkopf proteins, Nature, 411, 423, 10.1038/35077108
Marigo, 1996, Regulation of patched by sonic hedgehog in the developing neural tube, Proc Natl Acad Sci USA, 93, 9347, 10.1073/pnas.93.18.9346
Meyer, 2003, The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord, Dev Biol, 257, 343, 10.1016/S0012-1606(03)00065-4
Miller, 2003, Aberrant HOXC expression accompanies the malignant phenotype in prostate cancer, Cancer Res, 63, 5879
Mirosevich, 2004, Expression of Foxa transcription factors in the developing an adult Murine prostate, Prostate, 62, 339, 10.1002/pros.20131
Nelson, 2004, Convergance of Wnt, β-catenin and cadherin pathways, Science, 303, 1483, 10.1126/science.1094291
Oefelein, 1996, Expression of the homeotic gene Hox-d13 in the developing and adult mouse prostate, J Urol, 155, 342, 10.1016/S0022-5347(01)66657-6
Ornitz, 2001, Fibroblast growth factors, Genome Biol, 2, 1, 10.1186/gb-2001-2-3-reviews3005
Perriton, 2002, Sonic hedgehog signaling from the urethral epithelium controls external genital development, Dev Biol, 247, 26, 10.1006/dbio.2002.0668
Podlasek, 1999, Prostate development requires sonic hedgehog expressed by the urogenital sinus epithelium, Dev Biol, 209, 28, 10.1006/dbio.1999.9229
Podlasek, 1999, Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development, J Urol, 161, 1655, 10.1016/S0022-5347(05)68999-9
Podlasek, 1997, Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13, Dev Dyn, 208, 454, 10.1002/(SICI)1097-0177(199704)208:4<454::AID-AJA2>3.0.CO;2-H
Prescott, 1998, Isolation and androgen regulation of the human homeobox cDNA, NKX3.1, Prostate, 35, 71, 10.1002/(SICI)1097-0045(19980401)35:1<71::AID-PROS10>3.0.CO;2-H
Price, 1936, Normal development of the prostate and seminal vesicles of the rat with a study of experimental postnatal modifications, Am J Anat, 60, 79, 10.1002/aja.1000600105
Price, 1961, 366
Prins, 1993, Development of the prostate, 101
Prins, 1995, The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen, Endocrinology, 136, 1303, 10.1210/endo.136.3.7867585
Prins, 1997, Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes, Endocrinology, 138, 1801, 10.1210/endo.138.5.5106
Prins, 2001, Influence of neonatal estrogens on rat prostate development, Reprod Fertil Dev, 13, 241, 10.1071/RD00107
Prins, 2002, Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure, Endocrinology, 143, 3628, 10.1210/en.2002-220184
Prins, 1992, Androgen receptor expression and 5α-reductase activity along the proximal-distal axis of the rat prostatic duct, Endocrinology, 130, 3066, 10.1210/endo.130.5.1572313
Prins, 2006, The role of estrogens in normal and abnormal development of the prostate gland, Ann NY Acad Sci, 1089, 1, 10.1196/annals.1386.009
Prins, 2008, The role of estrogens and estrogen receptors in normal prostate growth and disease, Steroids, 73, 233, 10.1016/j.steroids.2007.10.013
Prins, 1998, Estrogen receptor-β messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats, Endocrinology, 139, 874, 10.1210/endo.139.3.5827
Pu, Y., Deng, L., Davies, P.J.P., Prins, G.S. (2003) Retinoic acid metabolizing enzymes, binding proteins and RXRs are differentially expressed in the developing and adult rat prostate lobes and are altered by neonatal estrogens in a lobe-specific manner. The Endocrine Society's 85th Annual Meeting; of Conference; Philadelphia, PA. p. 530 Abstract # P3-236
Pu, 2007, Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathways, Endocrinology, 148, 1697, 10.1210/en.2006-1113
Pu, 2004, Sonic hedgehog-patched-gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching, Dev Biol, 273, 257, 10.1016/j.ydbio.2004.06.002
Raman, 2003, Structural specificty of heparin binding growth factor family of proteins, Proc Natl Acad Sci, 100, 2357, 10.1073/pnas.0437842100
Schiavolino, 1997, Tissue-specific expression of murine Nkx3.1 in the male urogenital system, Dev Dyn, 209, 127, 10.1002/(SICI)1097-0177(199705)209:1<127::AID-AJA12>3.0.CO;2-Z
Schneider, 2000, Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate, Mech Dev, 95, 163, 10.1016/S0925-4773(00)00355-5
Shabsigh, 1999, Vascular anatomy of the rat ventral prostate, Anat Rec, 256, 403, 10.1002/(SICI)1097-0185(19991201)256:4<403::AID-AR7>3.0.CO;2-A
Shannon, 1983, Autoradiographic localization of androgen binding in the developing mouse prostate, Prostate, 4, 367, 10.1002/pros.2990040406
Shaw, 2007, Hedgehog signaling in the prostate, J Urol, 177, 832, 10.1016/j.juro.2006.10.061
Shen, 2003, Roles of the Nkx3.1 homeobox genes in prostate organogenesis and carcinogenesis, Dev Dyn, 228, 767, 10.1002/dvdy.10397
Shou, 2001, Dynamics of notch expression during murine prostate development and tumorigenesis, Cancer Res, 61, 7291
Simanainen, 2007, Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function, Endocrinology, 148, 2264, 10.1210/en.2006-1223
Sitteri, 1974, Testosterone formation and metabolism during male sexual differentiation in the human embryo, J Clin Endocrinol Metab, 38, 113, 10.1210/jcem-38-1-113
Sreenath, 1999, Androgen-independent expression of hoxb-13 in the mouse prostate, Prostate, 41, 203, 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J
Sugimura, 1986, Morphogenesis of ductal networks in the mouse prostate, Biol Reprod, 34, 961, 10.1095/biolreprod34.5.961
Takahashi, 2004, Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system, Exp Cell Res, 293, 144, 10.1016/j.yexcr.2003.09.024
Takeda, 1986, Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinus, J Endocrinol, 110, 467, 10.1677/joe.0.1100467
Takeda, 1985, Autoradiographic studies of androgen-binding sites in the rat urogenital sinus and postnatal prostate, J Endocrinol, 104, 87, 10.1677/joe.0.1040087
Tanaka, 2000, Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands, Dev Dyn, 219, 248, 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1054>3.3.CO;2-5
Tanji, 1994, Inhibitory effects of transforming growth factor-β 1 on androgen-induced development of neonatal mouse seminal vesicles in vitro, Endocrinology, 134, 1155, 10.1210/endo.134.3.8119154
Thomson, 2001, Role of androgens and fibroblast growth factors in prostatic development, Reproduction, 121, 187, 10.1530/rep.0.1210187
Thomson, 1999, Prostatic growth and development are regulated by FGF10, Development, 126, 3693, 10.1242/dev.126.16.3693
Timms, 1994, Ductal budding and branching patterns in the developing prostate, J Urol, 151, 1427, 10.1016/S0022-5347(17)35273-4
Timme, 1994, Mesenchymal-epithelial interactions and transforming growth factor-β expression during mouse prostate morphogenesis, Endocrinology, 134, 1039, 10.1210/endo.134.3.8119140
Tomlinson, 2004, Differential effects of transforming growth factor-β1 on cellular proliferation in the developing prostate, Endocrinology, 145, 4292, 10.1210/en.2004-0526
Tomlinson, 2004, Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-β1 and promoter elements, Endocrinology, 145, 1988, 10.1210/en.2003-0842
Uematsu, 2000, Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2, Biochem Biophys Res Commun, 272, 830, 10.1006/bbrc.2000.2872
Vanpoucke, 2008, Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease, Genome Biol, 8, R213.1
Walterhouse, 1999, Developmental pathways: sonic hedgehog-patched-GLI, Envir Health Persp, 107, 167, 10.1289/ehp.99107167
Waltregny, 2002, Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation, Prostate, 50, 162, 10.1002/pros.10045
Wang, 2003, Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells, J Biol Chem, 278, 18506, 10.1074/jbc.M300968200
Wang, 2006, Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer, Prostate, 66, 613, 10.1002/pros.20353
Wang, 2006, Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation, Dev Biol, 290, 66, 10.1016/j.ydbio.2005.11.009
Wang, 2004, Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement, J Biol Chem, 279, 24733, 10.1074/jbc.M401602200
Warot, 1997, Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts, Development, 124, 4781, 10.1242/dev.124.23.4781
Welt, 1998, Activin: an endocrine or paracrine agent?, Eur J Endocrinol, 139, 469, 10.1530/eje.0.1390469
Wilson, 1970, The intranuclear metabolism of testosterone in the accessory organs of reproduction, Rec Prog Horm Res, 26, 309
Wilson, 1971, Dihydrotestsoterone formation in the fetal tissue of the rabbit and rat, Endocrinology, 89, 659, 10.1210/endo-89-3-659
Yardy, 2005, Wnt signalling and prostate cancer, Prostate Cancer Prostatic Dis, 8, 119, 10.1038/sj.pcan.4500794
Zhang, 2006, SAGE reveals expression of Wnt signalling pathway members during mouse prostate development, Gene Expr Patterns, 6, 310, 10.1016/j.modgep.2005.07.005
Zhu, 2007, Sonic and desert hedgehog signaling in human fetal prostate development, Prostate, 67, 6, 10.1002/pros.20563