Effect of trazodone on hERG channel current and QT-interval

European Journal of Pharmacology - Tập 510 - Trang 75-85 - 2005
Paul Tarantino1, Neal Appleton2, Kate Lansdell2
1Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, United States
2Quintiles Preclinical Services, Quintiles Ltd., Riccarton, Edinburgh, United Kingdom

Tài liệu tham khảo

ADIS International, 1998 Ankier, 1981, Trazodone—a new assay procedure and some pharmacokinetic parameters, Br. J. Clin. Pharmacol., 11, 505, 10.1111/j.1365-2125.1981.tb01157.x Brown, 2000, Drug-induced long QT syndrome: is HERG the root of all evil?, Pharm. News, 7, 15 Burgess, 1982, The electrocardiographic and anticholinergic effects of trazodone and imipramine in man, Eur. J. Clin. Pharmacol., 23, 417, 10.1007/BF00605991 Byrne, 1982, Differential effects of trazodone and imipramine on intracardiac conduction in the anesthetized dog, Arch. Int. Pharmacodyn. Ther., 259, 259 Chiang, 2004, Inhibition of L-type Ca(2+) current in guinea pig ventricular myocytes by cisapride, J. Biomed. Sci., 11, 303 Crumb, 2000, Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions, J. Pharmacol. Exp. Ther., 292, 261 de Meester, 2001, Fatal overdose with trazodone: case report and literature review, Acta Clin. Belg., 56, 258, 10.1179/acb.2001.038 De Ponti, 2002, Safety of nonantiarrhythmic drugs that prolong the QT-interval or induce torsades de pointes: an overview, Drug Saf., 25, 263, 10.2165/00002018-200225040-00004 Ducic, 1997, Comparative effects of loratadine and terfenadine on cardiac K+ channels, J. Cardiovasc. Pharmacol., 30, 42, 10.1097/00005344-199707000-00007 Gintant, 2001, The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis, J. Cardiovasc. Pharmacol., 37, 607, 10.1097/00005344-200105000-00012 Goodman, 2001 Hayes, 1986, Adverse reactions to five new antidepressants, Clin. Pharm., 5, 471 Janowsky, 1983, Trazodone-aggravated ventricular arrhythmias, J. Clin. Psychopharmacol., 3, 372, 10.1097/00004714-198312000-00010 Lefebvre, 1997, Influence of itraconazole on the pharmacokinetics and electrocardiographic effects of astemizole, Br. J. Clin. Pharmacol., 43, 319, 10.1046/j.1365-2125.1997.00548.x Levenson, 1999, Prolonged QT-interval after trazodone overdose, Am. J. Psychiatry, 156, 969, 10.1176/ajp.156.6.969a Mazur, 1995, QT prolongation and polymorphous ventricular tachycardia associated with trasodone–amiodarone combination, Int. J. Cardiol., 52, 27, 10.1016/0167-5273(95)02435-Y Mohammad, 1997, Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride, Am. J. Physiol., 273, H2534 Park, 1999, Fluoxetine inhibits L-type Ca2+ and transient outward K+ currents in rat ventricular myocytes, Yonsei Med. J., 40, 144, 10.3349/ymj.1999.40.2.144 Physicians' Desk Reference, 1997. Thomson Healthcare, Montvale, NJ. Physicians' Desk Reference, 1998. Thomson Healthcare, Montvale, NJ. Pohl, 1986, Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease, J. Clin. Psychopharmacol., 6, 380, 10.1097/00004714-198612000-00022 Rampe, 1997, A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG, FEBS Lett., 417, 28, 10.1016/S0014-5793(97)01249-0 Redfern, 2003, Relationships between preclinical cardiac electrophysiology, clinical QT-interval prolongation and torsades de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development, Cardiovasc. Res., 58, 32, 10.1016/S0008-6363(02)00846-5 Roden, 2004, Drug-induced prolongation of the QT-interval, N. Engl. J. Med., 350, 1013, 10.1056/NEJMra032426 Roy, 1996, HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine, Circulation, 94, 817, 10.1161/01.CIR.94.4.817 Tibbles, 1997, Trazodone cardiotoxicity following overdose, J. Toxicol., Clin. Toxicol., 35, 499 Van de Merwe, 1984, Electrophysiological and haemodynamic changes with trazodone, amitriptyline and placebo in depressed outpatients, Curr. Med. Res. Opin., 9, 339, 10.1185/03007998409109602 Vitullo, 1990, Trazodone-related exercise-induced nonsustained ventricular tachycardia, Chest, 98, 247, 10.1378/chest.98.1.247 Webster, 2001, Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog, Xenobiotica, 31, 633, 10.1080/00498250110054632 Wittebole, 2000, Trazodone poisoning with torsades de pointes and prolonged need for inotropic support, J. Toxicol., Clin. Toxicol., 38, 248 Zhou, 1999, Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole, J. Cardiovasc. Electrophysiol., 10, 836, 10.1111/j.1540-8167.1999.tb00264.x Zitron, 2004, Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone, Naunyn-Schmiedeberg's Arch. Pharmacol., 370, 146, 10.1007/s00210-004-0952-3