Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

The Journal of Heart and Lung Transplantation - Tập 39 - Trang 1435-1444 - 2020
Marius M. Hoeper1,2, Christine Pausch3, Ekkehard Grünig4, Hans Klose5, Gerd Staehler6, Doerte Huscher7, David Pittrow3,8, Karen M. Olsson2, Carmine Dario Vizza9, Henning Gall10,2, Nicola Benjamin4, Oliver Distler11, Christian Opitz12, J. Simon R. Gibbs13, Marion Delcroix14, H. Ardeschir Ghofrani1,10,15, Stephan Rosenkranz16,17,18, Ralf Ewert19, Harald Kaemmerer20, Tobias J. Lange21
1Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
2German Center of Lung Research (DZL), Hannover, Germany
3Epidemiological Center, GWT-TUD GmbH, Dresden, Germany
4Centre for Pulmonary Hypertension, Thoraxclinic Heidelberg GmbH at Heidelberg University Hospital, Heidelberg, Germany
5Department of Respiratory Medicine, Eppendorf University Hospital, Hamburg, Germany
6Lungenklinik, Löwenstein, Germany
7Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin, Berlin, Germany
8Medical Faculty, Institute for Clinical Pharmacology, Technical University Dresden, Dresden, Germany
9Department of Cardiovascular and Respiratory Diseases, “Sapienza” University of Rome, Rome, Italy
10Department of Internal Medicine, Justus-Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany
11Department of Rheumatology, University Hospital, Zurich, Switzerland
12Department of Cardiology, DRK Kliniken Berlin Westend, Berlin, Germany
13Department of Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
14Department of Pneumology, University Hospital Leuven, Leuven, Belgium
15Department of Medicine, Imperial College London, London, United Kingdom
16Clinic III for Internal Medicine (Cardiology)
17Center for Molecular Medicine,
18Cologne Cardiovascular Research Center (CCRC), University of Cologne, Cologne, Germany
19Department of Respiratory Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany
20Deutsches Herzzentrum München, Klinik für angeborene Herzfehler und Kinderkardiologie, TU München, Munich, Germany
21Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany

Tài liệu tham khảo

Frost, 2019, Diagnosis of pulmonary hypertension, Eur Respir J, 53, 10.1183/13993003.01904-2018 Rich, 1987, Primary pulmonary hypertension. A national prospective study, Ann Intern Med, 107, 216, 10.7326/0003-4819-107-2-216 Zhang, 2011, Survival of Chinese patients with pulmonary arterial hypertension in the modern treatment era, Chest, 140, 301, 10.1378/chest.10-2327 Alves, 2015, Pulmonary arterial hypertension in the southern hemisphere: results from a registry of incident Brazilian cases, Chest, 147, 495, 10.1378/chest.14-1036 Ling, 2012, Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland, Am J Respir Crit Care Med, 186, 790, 10.1164/rccm.201203-0383OC Frost, 2011, The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US contemporary registries, Chest, 139, 128, 10.1378/chest.10-0075 Hoeper, 2013, Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry, Int J Cardiol, 168, 871, 10.1016/j.ijcard.2012.10.026 Hoeper, 2016, Incidence and prevalence of pulmonary arterial hypertension in Germany, Int J Cardiol, 203, 612, 10.1016/j.ijcard.2015.11.001 Rådegran, 2016, Characteristics and survival of adult Swedish PAH and CTEPH patients 2000-2014, Scand Cardiovasc J, 50, 243, 10.1080/14017431.2016.1185532 Badagliacca, 2020, Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis, J Heart Lung Transplant, 39, 310, 10.1016/j.healun.2019.12.012 Parikh, 2017, Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis, Pulm Circ, 7, 486, 10.1177/2045893217705891 Launay, 2018, Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis, PLoS One, 13, 10.1371/journal.pone.0197112 Hoeper, 2015, Pulmonary hypertension in patients with chronic fibrosing idiopathic interstitial pneumonias, PLoS One, 10, 10.1371/journal.pone.0141911 Opitz, 2016, Pre-capillary, combined, and post-capillary pulmonary hypertension: a pathophysiological continuum, J Am Coll Cardiol, 68, 368, 10.1016/j.jacc.2016.05.047 Hoeper, 2017, Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model, Eur Respir J, 50, 10.1183/13993003.00740-2017 Trip, 2013, Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses, Eur Respir J, 42, 1575, 10.1183/09031936.00184412 Hoeper, 2016, Diffusion capacity and mortality in patients with pulmonary hypertension due to heart failure with preserved ejection fraction, JACC Heart Fail, 4, 441, 10.1016/j.jchf.2015.12.016 Galiè, 2015, Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension, N Engl J Med, 373, 834, 10.1056/NEJMoa1413687 Kylhammar, 2018, A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension, Eur Heart J, 39, 4175, 10.1093/eurheartj/ehx257 Galiè, 2015, Eur Respir J, 46, 903, 10.1183/13993003.01032-2015 Galiè, 2016, Eur Heart J, 37, 67, 10.1093/eurheartj/ehv317 McLaughlin, 2019, Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: results from the AMBITION trial, J Heart Lung Transplant, 38, 1286, 10.1016/j.healun.2019.09.010 Statista. Global no.1 business data platform. Available at: www.statista.com . Reddy, 2018, A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction, Circulation, 138, 861, 10.1161/CIRCULATIONAHA.118.034646 Vachiéry, 2019, Pulmonary hypertension due to left heart disease, Eur Respir J, 53, 10.1183/13993003.01897-2018 Borlaug, 2016, Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction, Eur Heart J, 37, 3293, 10.1093/eurheartj/ehw241 Borlaug, 2010, Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction, Circ Heart Fail, 3, 588, 10.1161/CIRCHEARTFAILURE.109.930701 Seimetz, 2011, Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice, Cell, 147, 293, 10.1016/j.cell.2011.08.035 Olsson, 2017, More on idiopathic pulmonary arterial hypertension with a low diffusing capacity, Eur Respir J, 50, 10.1183/13993003.00354-2017 Hoeper, 2017, Is there a vanishing pulmonary capillary syndrome?, Lancet Respir Med, 5, 676, 10.1016/S2213-2600(17)30291-6 Lewis, 2020, Mild parenchymal lung disease and/or low diffusion capacity impacts survival and treatment response in patients diagnosed with idiopathic pulmonary arterial hypertension, Eur Respir J, 55, 10.1183/13993003.00041-2020