Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations

Congzhen Qiao1, Yajing Qiu1, Yun Zou1, Chen Hua1, Yuanbo Li1, Yunbo Jin1, Xiaoxi Lin1
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Tài liệu tham khảo

Fleetwood, 2002, Arteriovenous malformations, Lancet, 359, 863, 10.1016/S0140-6736(02)07946-1 Kohout, 1998, Arteriovenous malformations of the head and neck: natural history and management, Plast Reconstr Surg, 102, 643, 10.1097/00006534-199809010-00006 Jin, 2018, Treatment of early-stage extracranial arteriovenous malformations with intralesional interstitial bleomycin injection: a pilot study, Radiology, 287, 194, 10.1148/radiol.2017162076 Horbach, 2016, Intralesional bleomycin injections for vascular malformations: a systematic review and meta-analysis, Plast Reconstr Surg, 137, 244, 10.1097/PRS.0000000000001924 Rho, 2011, Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion, Biochem Biophys Res Commun, 404, 103, 10.1016/j.bbrc.2010.11.075 Noy, 2015, Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth, Oncogene, 34, 5821, 10.1038/onc.2015.34 Lee, 2017, Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis, J Clin Invest, 127, 457, 10.1172/JCI85145 Baeyens, 2016, Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia, J Cell Biol, 214, 807, 10.1083/jcb.201603106 Tu, 2014, Notch 1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations, BioMed Res Int, 2014, 368082, 10.1155/2014/368082 Galie, 2014, Fluid shear stress threshold regulates angiogenic sprouting, Proc Natl Acad Sci U S A, 111, 7968, 10.1073/pnas.1310842111 Bocci, 2019, Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer, Angiogenesis, 22, 117, 10.1007/s10456-018-9642-5 Zanivan, 2013, SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers, Mol Cell Proteomics, 12, 3599, 10.1074/mcp.M113.031344