Chapter 5 Recent Advances in the Treatment of Insomnia

Estivill, 2003, Clin. Drug Invest., 23, 315, 10.2165/00044011-200323060-00001 NIH State-of-the Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults (ed. NIH, National Heart, Lung and Blood Institute, National Center on Sleep Disorders Research), 2005. Sateia, 2004, Lancet, 364, 1959, 10.1016/S0140-6736(04)17480-1 Mindell, 2006, Pediatrics, 117, 1223, 10.1542/peds.2005-1693 Guide to Selected Publicly Available Sleep-Related Data Resources (ed. NIH, National Heart, Lung and Blood Institute. National Center on Sleep Disorders Research), 2006. Sivertsen, 2006, Am. J. Epidemiol., 163, 1018, 10.1093/aje/kwj145 Hillman, 2006, Sleep, 29, 299, 10.1093/sleep/29.3.299 Gershell, 2006, Nat. Rev. Drug Discov., 5, 15, 10.1038/nrd1932 P. Wong, in Scrip Reports (ed. PharmaprojectsPLUS), London, 2005, p. 36. Navab, 2006, Expert Opin. Pharmacother., 7, 1731, 10.1517/14656566.7.13.1731 Chebib, 2004, Ann. Rep. Med. Chem., 39, 13, 10.1016/S0065-7743(04)39002-0 Nutt, 2005, J. Psychopharmacol., 19, 125, 10.1177/0269881105051988 Roth, 2005, Sleep Med., 6, 487, 10.1016/j.sleep.2005.06.004 http://www.neurocrine.com/html/; 09/05/06 Neurocrine Reports Results of FDA End-of-Review Meeting on Indiplon Capsules NDA; 01/22/07 Neurocrine Announces Plans to Resubmit NDA for Indiplon Capsules in Q2 2007. K. Fang, P. Grover and T. Jerussi, WO Patent 2005044818, 2005. J. L. Falco, A. Palomer and A. Guglietta, WO Patent 2006051063, 2006. Selleri, 2005, J. Med. Chem., 48, 6756, 10.1021/jm058002n J. P. Dusza, J. D. Albright and A. S. Tomcufcik, US Patent 5538977, 1996. L. Anglada, A. Guglietta, M. Príncep and A. Palomer, WO Patent 2005014596, 2005. L. Anglada, A. Palomer and A. Guglietta, WO Patent 2006084835, 2006. Wafford, 2006, Curr. Opin. Pharmacol., 6, 30, 10.1016/j.coph.2005.10.004 Roth, 2006, Sleep, 29, 335, 10.1093/sleep/29.3.335 http://www.neurogen.com//pipeline.htm, 29 March 2007. Zhdanova, 2005, Pro. Sleep Med. Rev., 9, 51, 10.1016/j.smrv.2004.04.003 van den Heuvel, 2005, Sleep Med. Rev., 9, 71, 10.1016/j.smrv.2004.07.001 Fitzgerald, 2004, Ann. Rep. Med. Chem., 39, 25, 10.1016/S0065-7743(04)39003-2 Borja, 2006, Clin. Therap., 28, 1540, 10.1016/j.clinthera.2006.10.016 M. Kryger, S. Wang-Weigand and T. Roth, Sleep Breath, 2007, in press. J. Mulchahey, F. Zemlan, D. Mayleben, M. Scharf, R. Rosenberg and A. Lankford, 86th Annu. Meet. Endocr. Soc., Jun 16–19, 2004, New Orleans, Abstract P2-223. J. Mulchahey, F. Zemlan, D. Mayleben, M. Scharf, R. Rosenberg and A. Lankford, 34th Annu. Meet. Soc. Neurosci., Oct 23–27, 2004b, San Diego, Abstract 546-3. J. Mulchahey, F. Zemlan, D. Mayleben, M. Scharf, R. Rosenberg and A. Lankford, 18th Congr. Eur. Coll. Neuropsychopharmacol. (ECNP), Oct 22–26, 2005, Amsterdam, Abstract P.8-018. F. Zemlan, J. Mulchahey, D. Mayleben, M. Scharf, R. Rosenberg and A. Lankford, 45th Annu. NCDEU Meet., Jun 6–9, 2005, Boca Raton, Abstract II-90, p. 306. F. Zemlan, 35th Annu. Meet. Soc. Neurosci., Nov 12–16, 2005, Washington DC, Abstract 310-6. Zemlan, 2005, J. Clin. Psychiat., 66, 384, 10.4088/JCP.v66n0316 Nickelsen, 2002, Chronobiol. Int., 19, 915, 10.1081/CBI-120014108 J. J. Mulchahey and F. P. Zemlan, 33rd Annu. Meet. Soc. Neurosci., Nov 8–12, 2003, New Orleans, Abstract 617.7. S. M. Rajaratnam, M. H. Polymeropoulos, D. M. Fischer, C. H. Scott, G. Birznieks, E. B. Klermann, Sleep, 2006, 29(Abst.), Abst 0159. Dubocovich, 2006, Curr. Opin. Investig. Drugs, 7, 670 Annual Report of European Medicines Agency, March 2007, p. 103. Lucini, 2004, J. Med. Chem., 47, 4202, 10.1021/jm040768k V. Audinot, L. Grandcolas, A. Bonnaud, P. Delagrange, G. Guillaumet and J. A. Boutin, 34th Annu. Meet. Soc. Neurosci., Oct 23–27, 2004, San Diego, Abstract 355-4. S. Yous, C. Mesangeau, D. Lesieur, P. Renard, J. A. Boutin, V. Audinot, P. Delagrange and C. Bennejean, WO Patent 2005012282, 2005. G. Guillaumet, S. Berteina-Raboin, S. El Kazzouli, P. Delagrange and D.-H. Caignard, WO Patent 2006027474, 2006. Tsotinis, 2006, J. Med. Chem., 49, 3509, 10.1021/jm0512544 G. P. Stack and J. L. Gross, WO Patent 2006116136, 2006. De Lecea, 1998, Proc. Natl. Acad. Sci. USA, 95, 322, 10.1073/pnas.95.1.322 Sakurai, 1998, Cell, 92, 573, 10.1016/S0092-8674(00)80949-6 Brown, 2003, Drug News Perspect., 16, 75, 10.1358/dnp.2003.16.2.829323 Sakurai, 2005, Sleep Med. Rev., 9, 231, 10.1016/j.smrv.2004.07.007 Tomoyo, 2006, J. Pept. Sci., 12, 443, 10.1002/psc.747 Lang, 2004, J. Med. Chem., 47, 1153, 10.1021/jm030982t Brough, 2001, Br. J. Pharmacol., 134 Brisbare-Roch, 2007, Nat. Med., 13, 150, 10.1038/nm1544 C. L. Branch, R. A. Porter, D. J. Nash and S. Coulton, WO Patent 2003051873, 2003. Nilaweera, 2003, Neuroscience, 119, 713, 10.1016/S0306-4522(02)00869-2 T. Weller, R. Koberstein, H. Aissaoui, M. Clozel and W. Fischli, WO Patent 2005118548, 2005. G. Chan, A. Johns, K. Widdowson, R. A. Porter and A. Jurewicz, WO Patent 1999009024, 1999. Porter, 2001, Bioorg. Med. Chem. Lett., 11, 1907, 10.1016/S0960-894X(01)00343-2 Langmead, 2004, Br. J. Pharmacol., 141, 340, 10.1038/sj.bjp.0705610 R. A. Porter and A. Johns, WO Patent 2000047576, 2000. H. Aissaoui, M. Cappi, R. Koberstein, W. Fischli and M. Clozel, WO Patent 2001068609, 2001. K. Yamada, H. Iwaasa and M. Hirose, WO Patent 2001085693, 2001. Hirose, 2003, Bioorg. Med. Chem. Lett., 13, 4497, 10.1016/j.bmcl.2003.08.038 H. Aissaoui, M. Clozel, W. Fischli, R. Koberstein, T. Sifferlen and T. Weller, WO Patent 2002051838 and WO Patent 2002051232, 2002. H. Aissaoui, M. Clozel, W. Fischli, R. Koberstein, T. Sifferlen and T. Weller, WO Patent 2004085403, 2004. C. L. Branch, K. Thewlis, G. Stemp and C. N. Johnson, WO Patent 2001096302, 2001. C. L. Branch, C. N. Johnson, K. Thewlis, G. Stemp and A. B. Smith, WO Patent 2002044172, 2002. C. L. Branch, S. Coulton, A. Johns, K. Thewlis, R. A. Porter, G. Stemp and C. N. Johnson, WO Patent 2002090355, 2002. C. L. Branch, G. Stemp, D. J. Nash and C. N. Johson, WO Patent 2003032991, 2003. C. L. Branch, G. Stemp, D. J. Nash and C. N. Johnson, WO Patent 2003041711, 2003. C. L. Branch, A. Johns, C. N. Johnson, K. Thewlis, R. A. Porter, R. E. A. Stead., G. Stemp and R. Novelli, WO Patent 2003051871, 2003. C. L. Branch, S. Coulton, G. Stemp, D. J. Nash, R. A. Porter and A. Johns, WO Patent 2004026866, 2004. C. L. Branch , R. A. Porter and J.-P. Pilleux, WO Patent 2004041816, 2004. P. Gaillard, C. N. Johnson, K. M. Thewlis, R. A. Porter, G. Stemp and R. Novelli, WO Patent 2002089800, 2002. W. N. Chan, R. E. A. Stead, R. A. Porter and D. J. Nash, WO Patent 2004041791, 2004. R. A. Porter and S. Coulton, WO Patent 2004041807, 2004. P. J. Coleman and J. Schreier, WO Patent 2006110626, 2006. H. Aissaoui, M. Clozel, T. Weller, R. Koberstein, T. Sifferlen and W. Fischli, WO Patent 2004004733, 2004. W. Fischli, H. Aissaoui, R. Koberstein, T. Sifferlen, T. Weller and M. Clozel, WO Patent 2004096780, 2004. McAtee, 2004, Bioorg. Med. Chem. Lett., 14, 4225, 10.1016/j.bmcl.2004.06.032 N. I. Carruthers, T. K. Jones, X. Li, S. W. Sutton, L. C. McAtee, V. K. Phuong, D. A. Rudolph and T. W. Lovenberg, WO Patent 2004052876, 2004. S. W. Sutton and T. W. Lovenberg, WO Patent 2004054510, 2004. G. Courtemanche, P. Despeyroux, E. Fontaine, P. Rochard and C. Serradeil Le Gal, WO Patent 2006024779, 2006. H. Aissaoui, M. Clozel, T. Weller, R. Koberstein, T. Sifferlen and Fischli, WO Patent 2004033418, 2004. M. J. Breslin, C. D. Cox and D. B. Whitman, WO Patent 2007025069, 2007. Prober, 2006, J. Neurosci., 26, 13400, 10.1523/JNEUROSCI.4332-06.2006 Jones, 2005, TIPS, 26, 578 Edgar, 2006, Sleep, 29 Ferguson., 2004, Otolaryngol. Head Neck Surg., 130, 617, 10.1016/j.otohns.2004.02.001 T. Roth, R. Rogowski, S. Hull, M. Cohn, A. Lankford, D. Mayleben and M. Scharf, 46th Annual NCDEU Meeting, June 2006, Abst II – 99. Roberts, 2006, Curr. Opin. Investig. Drugs, 7, 653 Wang, 2006, Drugs Future, 31, 939, 10.1358/dof.2006.031.11.1047693 R. Luthringer, W. Prosser, M. Arnal, M. Martin, C. Staner, W. Shanahan and L. Staner, 20th APSS (June 17–22, Salt Lake City), Sleep 2006, 29 (Abst, Suppl), Abstract 0116.