SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

Cell - Tập 147 - Trang 1459-1472 - 2011
Sergiy Libert1, Kelli Pointer1, Eric L. Bell1, Abhirup Das1, Dena E. Cohen1,2, John M. Asara3, Karen Kapur4, Sven Bergmann4, Martin Preisig5, Takeshi Otowa6, Kenneth S. Kendler6, Xiangning Chen6, John M. Hettema6, Edwin J. van den Oord7, Justin P. Rubio8, Leonard Guarente1
1Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2HHMI/Harvard Department of Stem Cell and Regenerative Biology, Cambridge, MA 02138, USA
3Beth Israel Deaconess Medical Center and Department of Medicine and Harvard Medical School, Boston, MA 02115, USA
4Department of Medical Genetics, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland
5Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland
6Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
7Center for Biomarker Research and Personalized Medicine, Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
8Quantitative Sciences, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK

Tài liệu tham khảo

Abe, 2011, Altered sirtuin deacetylase gene expression in patients with a mood disorder, J. Psychiatr. Res., 45, 1106, 10.1016/j.jpsychires.2011.01.016 Aklillu, 2009, Association of MAOA gene functional promoter polymorphism with CSF dopamine turnover and atypical depression, Pharmacogenet. Genomics, 19, 267, 10.1097/FPC.0b013e328328d4d3 American Psychiatric Association. (1994). Diagnostic and statistical manual of mental health disorders, 4th edition (Washington DC). Ashburner, 2000, Gene ontology: tool for the unification of biology, Nat. Genet., 25, 25, 10.1038/75556 Bordone, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x Brown, 1992, HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma, Proc. Natl. Acad. Sci. USA, 89, 8492, 10.1073/pnas.89.18.8492 Chen, 2005, Increase in activity during calorie restriction requires Sirt1, Science, 310, 1641, 10.1126/science.1118357 Chen, 2008, The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration, Exp. Gerontol., 43, 1086, 10.1016/j.exger.2008.08.050 Clarke, 2011, Basic statistical analysis in genetic case-control studies, Nat. Protoc., 6, 121, 10.1038/nprot.2010.182 Cohen, 2009, Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction, Genes Dev., 23, 2812, 10.1101/gad.1839209 Coyle, 2002, Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice, Physiol. Behav., 77, 387, 10.1016/S0031-9384(02)00885-5 Cunha, 1978, Evaluation of psychotropic drugs with a modified open field test, Pharmacology, 16, 259, 10.1159/000136777 Donmez, 2010, SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10, Cell, 142, 320, 10.1016/j.cell.2010.06.020 Franková, 1968, Influence of malnutrition in early life on exploratory behavior of rats, J. Nutr., 96, 477, 10.1093/jn/96.4.477 Gao, 2010, A novel pathway regulates memory and plasticity via SIRT1 and miR-134, Nature, 466, 1105, 10.1038/nature09271 Good, 2008, Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity, Exerc. Sport Sci. Rev., 36, 187, 10.1097/JES.0b013e31818782dd Hampp, 2008, Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood, Curr. Biol., 18, 678, 10.1016/j.cub.2008.04.012 Hettema, 2008, Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes, Biol. Psychiatry, 64, 302, 10.1016/j.biopsych.2008.03.014 2003, The International HapMap Project, Nature, 426, 789, 10.1038/nature02168 Kendler, 2001, Panic syndromes in a population-based sample of male and female twins, Psychol. Med., 31, 989, 10.1017/S0033291701004226 Kessler, 2005, Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication, Arch. Gen. Psychiatry, 62, 617, 10.1001/archpsyc.62.6.617 Kim, 2008, DBC1 is a negative regulator of SIRT1, Nature, 451, 583, 10.1038/nature06500 Kishi, 2010, SIRT1 gene is associated with major depressive disorder in the Japanese population, J. Affect. Disord., 126, 167, 10.1016/j.jad.2010.04.003 Livak, 1999, Allelic discrimination using fluorogenic probes and the 5′ nuclease assay, Genet. Anal., 14, 143, 10.1016/S1050-3862(98)00019-9 Marinescu, 2005, MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes, BMC Bioinformatics, 6, 79, 10.1186/1471-2105-6-79 Michán, 2010, SIRT1 is essential for normal cognitive function and synaptic plasticity, J. Neurosci., 30, 9695, 10.1523/JNEUROSCI.0027-10.2010 Minor, 2008, Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling, Behav. Brain Res., 189, 202, 10.1016/j.bbr.2007.12.030 Nordquist, 2010, Serotonin, genetic variability, behaviour, and psychiatric disorders—a review, Ups. J. Med. Sci., 115, 2, 10.3109/03009730903573246 Nurnberger, 1994, Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative, Arch. Gen. Psychiatry, 51, 849, 10.1001/archpsyc.1994.03950110009002 Pfister, 2008, Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity, PLoS ONE, 3, e4090, 10.1371/journal.pone.0004090 Preisig, 2009, The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors, BMC Psychiatry, 9, 9, 10.1186/1471-244X-9-9 Prozorovski, 2008, Sirt1 contributes critically to the redox-dependent fate of neural progenitors, Nat. Cell Biol., 10, 385, 10.1038/ncb1700 Shepherd, 1994, Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety, Psychopharmacology (Berl.), 116, 56, 10.1007/BF02244871 Spielberger, 1970 Spitzer, 1992, The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description, Arch. Gen. Psychiatry, 49, 624, 10.1001/archpsyc.1992.01820080032005 Thorisson, 2005, The International HapMap Project Web site, Genome Res., 15, 1592, 10.1101/gr.4413105 Von Frijtag, 2000, Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats, Behav. Brain Res., 117, 137, 10.1016/S0166-4328(00)00300-4 Weed, 1997, Activity measures in rhesus monkeys on long-term calorie restriction, Physiol. Behav., 62, 97, 10.1016/S0031-9384(97)00147-9 Zhao, 2008, Negative regulation of the deacetylase SIRT1 by DBC1, Nature, 451, 587, 10.1038/nature06515 Cohen, D.E., Supinski, A.M., Bonkowski, M.S., Donmez, G., and Guarente, L.P. (2009). Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812–2817. Gao, J., Wang, W.Y., Mao, Y.W., Gräff, J., Guan, J.S., Pan, L., Mak, G., Kim, D., Su, S.C., and Tsai, L.H. (2010). A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466, 1105–1109. Krivan, V. (2007). The Lotka-Volterra predator-prey model with foraging-predation risk trade-offs. Am. Nat. 170, 771–782. Marinescu, V.D., Kohane, I.S., and Riva, A. (2005). MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics 6, 79. Satoh, A., Brace, C.S., Ben-Josef, G., West, T., Wozniak, D.F., Holtzman, D.M., Herzog, E.D., and Imai, S. (2010). SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J. Neurosci. 30, 10220–10232.