SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Sergiy Libert1, Kelli Pointer1, Eric L. Bell1, Abhirup Das1, Dena E. Cohen1,2, John M. Asara3, Karen Kapur4, Sven Bergmann4, Martin Preisig5, Takeshi Otowa6, Kenneth S. Kendler6, Xiangning Chen6, John M. Hettema6, Edwin J. van den Oord7, Justin P. Rubio8, Leonard Guarente1
1Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2HHMI/Harvard Department of Stem Cell and Regenerative Biology, Cambridge, MA 02138, USA
3Beth Israel Deaconess Medical Center and Department of Medicine and Harvard Medical School, Boston, MA 02115, USA
4Department of Medical Genetics, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland
5Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland
6Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
7Center for Biomarker Research and Personalized Medicine, Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
8Quantitative Sciences, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK