Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

Nucleic Acids Research - Tập 40 Số 4 - Trang 1609-1620 - 2012
Ping Li1, Yuhao Zhao2, Xiaoyan Wu2, Minjie Xia2, Mingming Fang2, Yasumasa Iwasaki2, Jiahao Sha2, Qi Chen2, Yong Xu2, Aiguo Shen2
1State Key Laboratory of Reproductive Medicine and Department of Pathophysiology, Key Laboratory of Cardiovascular Disease,The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
2Nanjing Medical University, Nanjing, China

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Tài liệu tham khảo

Yechoor, 2002, Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice, Proc. Natl Acad. Sci. USA, 99, 10587, 10.1073/pnas.142301999

Simoneau, 1999, Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss, FASEB J., 13, 2051, 10.1096/fasebj.13.14.2051

Patti, 2003, Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1, Proc. Natl Acad. Sci. USA, 100, 8466, 10.1073/pnas.1032913100

Kelley, 2002, Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes, Diabetes, 51, 2944, 10.2337/diabetes.51.10.2944

Canto, 2009, PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure, Curr. Opin. Lipidol., 20, 98, 10.1097/MOL.0b013e328328d0a4

Gross, 2008, The role of FoxO in the regulation of metabolism, Oncogene, 27, 2320, 10.1038/onc.2008.25

Cheng, 2009, Foxo1 integrates insulin signaling with mitochondrial function in the liver, Nat. Med., 15, 1307, 10.1038/nm.2049

Feige, 2008, Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation, Cell. Metab., 8, 347, 10.1016/j.cmet.2008.08.017

Kitamura, 2005, FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction, Cell. Metab., 2, 153, 10.1016/j.cmet.2005.08.004

Frescas, 2005, Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes, J. Biol. Chem., 280, 20589, 10.1074/jbc.M412357200

Banks, 2008, SirT1 gain of function increases energy efficiency and prevents diabetes in mice, Cell. Metab., 8, 333, 10.1016/j.cmet.2008.08.014

Lin, 2000, Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae, Science, 289, 2126, 10.1126/science.289.5487.2126

Liang, 2009, SIRT1 and insulin resistance, Nat. Rev. Endocrinol., 5, 367, 10.1038/nrendo.2009.101

Rutanen, 2010, SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity, Diabetes, 59, 829, 10.2337/db09-1191

de Kreutzenberg, 2010, Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms, Diabetes, 59, 1006, 10.2337/db09-1187

Milne, 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, 450, 712, 10.1038/nature06261

Hotamisligil, 2008, Nutrient sensing and inflammation in metabolic diseases, Nat. Rev. Immunol., 8, 923, 10.1038/nri2449

Liu, 2009, Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice, Nat. Med., 15, 940, 10.1038/nm.1994

Lee, 2007, The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN, J. Mol. Biol., 369, 967, 10.1016/j.jmb.2007.03.072

McGillicuddy, 2009, Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway, J. Biol. Chem., 284, 31936, 10.1074/jbc.M109.061655

Kong, 2009, HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells, J. Mol. Cell. Cardiol., 46, 292, 10.1016/j.yjmcc.2008.10.023

Valenta, 2006, HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies, EMBO J., 25, 2326, 10.1038/sj.emboj.7601147

Okazaki, 2010, PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1, Endocr. J., 57, 403, 10.1507/endocrj.K10E-004

Franko, 2008, CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation, Mol. Cell. Biol., 28, 2446, 10.1128/MCB.00980-07

Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131

Gilde, 2003, Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism, Circ. Res., 92, 518, 10.1161/01.RES.0000060700.55247.7C

Huss, 2002, Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha, J. Biol. Chem., 277, 40265, 10.1074/jbc.M206324200

Fang, 2009, RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells, Nucleic Acids Res., 37, 4393, 10.1093/nar/gkp398

Xu, 2004, Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma), J. Biol. Chem., 279, 41319, 10.1074/jbc.M404174200

Xu, 2008, CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation dependent interactions with co-repressor molecules, J. Biol. Chem., 283, 1243, 10.1074/jbc.M707180200

Kong, 2009, PPARgamma enhances IFNgamma-mediated transcription and rescues the TGFbeta antagonism by stimulating CIITA in vascular smooth muscle cells, J. Mol. Cell. Cardiol., 46, 748, 10.1016/j.yjmcc.2009.01.011

Van Rechem, 2010, Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells, Mol. Cell Biol., 30, 4045, 10.1128/MCB.00582-09

Zika, 2003, Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation, Mol. Cell. Biol., 23, 3091, 10.1128/MCB.23.9.3091-3102.2003

Coppari, 2009, The role of transcriptional regulators in central control of appetite and body weight, Nat. Clin. Pract. Endocrinol. Metab., 5, 160, 10.1038/ncpendmet1070

Wu, 2009, Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities, Mol. Cell. Biol., 29, 5639, 10.1128/MCB.00661-09

Ting, 2005, CATERPILLER: a novel gene family important in immunity, cell death, and diseases, Annu. Rev. Immunol., 23, 387, 10.1146/annurev.immunol.23.021704.115616

Schroder, 2011, The NLRP3 inflammasome: a sensor for metabolic danger?, Science, 327, 296, 10.1126/science.1184003

Vandanmagsar, 2011, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance, Nat. Med., 17, 179, 10.1038/nm.2279

Fleuriel, 2009, HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors, Int. J. Biochem. Cell Biol., 41, 26, 10.1016/j.biocel.2008.05.028

Chen, 2005, Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses, Cell, 123, 437, 10.1016/j.cell.2005.08.011

Deltour, 2002, The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif, Mol. Cell Biol., 22, 4890, 10.1128/MCB.22.13.4890-4901.2002

Zhang, 2007, Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex, Proc. Natl Acad. Sci. USA, 104, 829, 10.1073/pnas.0610590104

Jagannathan-Bogdan, Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes, J. Immunol., 186, 1162, 10.4049/jimmunol.1002615

Zika, 2005, Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes, Curr. Opin. Immunol., 17, 58, 10.1016/j.coi.2004.11.008

Jin, 2011, The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation, Hepatology., 54, 989, 10.1002/hep.24471

Li, 2000, Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3, EMBO J., 19, 4342, 10.1093/emboj/19.16.4342

Alenghat, 2008, Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology, Nature, 456, 997, 10.1038/nature07541

McGee, 2010, Histone modifications and skeletal muscle metabolic gene expression, Clin. Exp. Pharmacol. Physiol., 37, 392, 10.1111/j.1440-1681.2009.05311.x