Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum

Rudin, 1982, The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: substrate beriberi, Med. Hypotheses, 8, 17, 10.1016/0306-9877(82)90088-3 Salem, 1986, Docosahexaenoic acid: membrane function and metabolism, 263 Salem, 1989, Omega-3 fatty acids: molecular and biochemical aspects, 109 Okuyama, 1997, Dietary fatty acids—the n-6/n-3 balances and chronic elderly diseases. Excess linoleic acid and relative n-3 deficiency syndrome seen in Japan, Prog. Lipid Res., 35, 409, 10.1016/S0163-7827(96)00012-4 Tinoco, 1982, Dietary requirements and functions of alpha-linolenic acid in animals, Prog. Lipid Res., 21, 1, 10.1016/0163-7827(82)90015-7 Innis, 1991, Essential fatty acids in growth and development, Prog. Lipid Res., 30, 39, 10.1016/0163-7827(91)90006-Q Wheeler, 1975, Visual membranes: specificity of fatty acid precursors for the electrical response to illumination, Science, 188, 1312, 10.1126/science.1145197 Lamptey, 1976, A possible essential role for dietary linolenic acid in the development of the young rat, J. Nutr., 106, 86, 10.1093/jn/106.1.86 Yamamoto, 1987, Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats, J. Lipid Res., 28, 144, 10.1016/S0022-2275(20)38713-7 Bourre, 1989, The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats, J. Nutr., 119, 1880, 10.1093/jn/119.12.1880 Greiner, 1999, Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks, Lipids, 34, S239, 10.1007/BF02562305 Nakashima, 1993, Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice, J. Lipid Res., 34, 239, 10.1016/S0022-2275(20)40751-5 Wainwright, 1998, Effects of dietary n-3 fatty acid deficiency on Morris watermaze performance and amphetamine-induced conditioned place preference in rats, Nutr. Neurosci., 1, 281, 10.1080/1028415X.1998.11747238 Frances, 1996, Influence of a dietary alpha-linolenic acid deficiency on learning in the Morris water maze and on the effects of morphine, Eur. J. Pharmacol., 298, 217, 10.1016/0014-2999(95)00825-X Moriguchi, 2000, Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration, J. Neurochem., 75, 2563, 10.1046/j.1471-4159.2000.0752563.x Pawlosky, 1997, Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets, Am. J. Clin. Nutr., 65, 465, 10.1093/ajcn/65.2.465 Neuringer, 1984, Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys, J. Clin. Invest., 73, 272, 10.1172/JCI111202 Neuringer, 1986, Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys, Proc. Natl. Acad. Sci. USA, 83, 4021, 10.1073/pnas.83.11.4021 Connor, 1988, The effect of n-3 fatty acid deficiency and repletion upon the fatty acid composition and function of brain and retina, 275 Farquharson, 1992, Infant cerebral cortex phospholipid fatty-acid composition and diet, Lancet, 340, 810, 10.1016/0140-6736(92)92684-8 Jamieson, 1999, Infant cerebellar gray and white matter fatty acids in relation to age and diet, Lipids, 34, 1065, 10.1007/s11745-999-0458-5 Makrides, 1994, Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants, Am. J. Clin. Nutr., 60, 189, 10.1093/ajcn/60.2.189 Carlson, 1993, Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation, Am. J. Clin. Nutr., 58, 35, 10.1093/ajcn/58.1.35 Uauy, 1990, Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates, Pediatr. Res., 28, 485, 10.1203/00006450-199011000-00014 Birch, 1992, Dietary essential fatty acid supply and visual acuity development, Invest. Ophthalmol. Vis. Sci., 33, 3242 Makrides, 1995, Are long-chain polyunsaturated fatty acids essential nutrients in infancy?, Lancet, 345, 1463, 10.1016/S0140-6736(95)91035-2 Agostoni, 1995, Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long-chain polyunsaturated fatty acids, Pediatr. Res., 38, 262, 10.1203/00006450-199508000-00021 Birch, 2000, A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants, Dev. Med. Child Neurol., 42, 174, 10.1017/S0012162200000311 Werkman, 1996, A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months, Lipids, 31, 91, 10.1007/BF02522417 Carlson, 1996, A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months, Lipids, 31, 85, 10.1007/BF02522416 Willats, 1998, Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age, Lancet, 352, 688, 10.1016/S0140-6736(97)11374-5 Youyou, 1986, Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain, J. Neurochem., 46, 224, 10.1111/j.1471-4159.1986.tb12950.x Bourre, 1987, Slow recovery of the fatty acid composition of sciatic nerve in rats fed a diet initially low in n-3 fatty acids, Lipids, 22, 535, 10.1007/BF02540371 Homayoun, 1988, Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet, J. Neurochem., 51, 45, 10.1111/j.1471-4159.1988.tb04833.x Bourre, 1989, Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat, J. Nutr., 119, 15, 10.1093/jn/119.1.15 Connor, 1990, Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys, J. Lipid Res., 31, 237, 10.1016/S0022-2275(20)43209-2 Connor, 1993, The comparative importance of prenatal and postnatal n-3 fatty acid deficiency: repletion at birth and later, 156 Connor, 1988, The effect of n-3 fatty acid deficiency and repletion upon the fatty acid composition and function of brain and retina, 275 Weisinger, 1999, Effects of dietary n-3 deficiency and repletion in the guinea pig retina, Invest. Ophthalmol. Vis. Sci., 40, 327 Jensen, 1999, Lipids in human milk, Lipids, 34, 1243, 10.1007/s11745-999-0477-2 Reeves, 1993, Committee report on the AIN-93 purified rodent diet, J. Nutr., 123, 1939, 10.1093/jn/123.11.1939 Lepage, 1986, Direct transesterification of all classes of lipids in a one-step reaction, J. Lipid Res., 27, 114, 10.1016/S0022-2275(20)38861-1 Stinson, 1991, Recycling of docosahexaenoic acid in rat retinas during n-3 fatty acid deficiency, J. Lipid Res., 32, 2009, 10.1016/S0022-2275(20)41904-2 Contreras, 2000, Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain, J. Neurochem., 75, 2392, 10.1046/j.1471-4159.2000.0752392.x Menard, 1998, Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain, J. Neurochem., 71, 2151, 10.1046/j.1471-4159.1998.71052151.x Fu, 2000, Novel pathway of metabolism of alpha-linolenic acid in the guinea pig, Pediatr. Res., 47, 414, 10.1203/00006450-200003000-00021 Hassam, 1975, The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats, Lipids, 10, 417, 10.1007/BF02532447 Sinclair, 1975, Long chain polyunsaturated fatty acids in the mammalian brain, Proc. Nutr. Soc., 34, 287, 10.1079/PNS19750051 Salem, 1996, Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants, Proc. Natl. Acad. Sci. USA, 93, 49, 10.1073/pnas.93.1.49 Sauerwald, 1966, Effect of dietary alpha-linolenic acid intake on incorporation of docosahexaenoic and arachidonic acids into plasma phospholipids of term infants, Lipids, 31, S131, 10.1007/BF02637064 Uauy, 2000, Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth, Pediatr. Res., 47, 127, 10.1203/00006450-200001000-00022 Carnielli, 1996, The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids, Pediatr. Res., 40, 169, 10.1203/00006450-199607000-00029 Su, 1999, Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs, Lipids, 34, S347, 10.1007/BF02562339 Su, 1999, Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons, Pediatr. Res., 45, 87, 10.1203/00006450-199901000-00015 Woods, 1996, Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat, Pediatr. Res., 40, 687, 10.1203/00006450-199611000-00007 Abedin, 1999, The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig, Lipids, 34, 475, 10.1007/s11745-999-0387-3 McGuill, 1989, Biological effects of blood loss: implications for sampling volumes and techniques, Inst. Lab. Animal Res. News, 31, 5, 10.1093/ilar.31.4.5