Recipient CTLA-4*CT60-AA genotype is a prognostic factor for acute graft-versus-host disease in hematopoietic stem cell transplantation for thalassemia

Human Immunology - Tập 73 - Trang 282-286 - 2012
Sandro Orrù1, Nicola Orrù1, Emmanouil Manolakos1,2, Roberto Littera3, Giovanni Caocci4,5, Giovanna Giorgiani6, Alice Bertaina7, Daria Pagliara7, Claudio Giardini8, Sonia Nesci9, Franco Locatelli7, Carlo Carcassi1,3, Giorgio La Nasa4,5
1Genetica Medica, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, 09126 Cagliari, Italy
2Bioiatriki S.A, Kifisias Av. 132 and Papada, GR-115 26, Athens, Greece
3Centro Regionale Trapianti, Ospedale R. Binaghi, ASL Cagliari, 09126 Cagliari, Italy
4Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, ASL Cagliari, 09126 Cagliari, Italy
5Cattedra di Ematologia, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, 09126 Italy
6Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
7Dipartimento di Oncoematologia e Medicina Trasfusionale, IRCCS, Ospedale Bambino Gesù, Università di Pavia, 00165 Rome, Italy
8Ematologia e Centro Trapianti di Midollo Osseo, Azienda Ospedaliera Marche Nord, Presidio di Pesaro, 61100 Pesaro, Italy
9Settore Immunogenetica Laboratorio Patologia Clinica, Azienda Ospedaliera Marche Nord, Presidio di Pesaro, 61100 Pesaro, Italy

Tài liệu tham khảo

Seggewiss, 2010, Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update, Blood, 115, 3861, 10.1182/blood-2009-12-234096 Childs, 2004, Nonmyeloablative allogeneic immunotherapy for solid tumors, Annu Rev Med, 55, 459, 10.1146/annurev.med.55.091902.104511 Reddy, 2003, Immunobiology of acute graft-versus-host disease, Blood Rev, 17, 187, 10.1016/S0268-960X(03)00009-2 Hodi, 2007, Cytotoxic T-lymphocyte-associated antigen-4, Clin Cancer Res, 13, 5238, 10.1158/1078-0432.CCR-07-0813 Magistrelli, 1999, A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells, Eur J Immunol, 29, 3596, 10.1002/(SICI)1521-4141(199911)29:11<3596::AID-IMMU3596>3.0.CO;2-Y Ueda, 2003, Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease, Nature, 423, 506, 10.1038/nature01621 Kavvoura, 2007, Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis, J Clin Endocrinol Metab, 92, 3162, 10.1210/jc.2007-0147 Oaks, 2000, Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease, J Immunol, 164, 5015, 10.4049/jimmunol.164.10.5015 Wang, 2002, Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence, J Neuroimmunol, 130, 224, 10.1016/S0165-5728(02)00228-X Liu, 2003, Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus, Scand J Immunol, 57, 568, 10.1046/j.1365-3083.2003.01232.x Wong, 2005, Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus, Rheumatology, 44, 989, 10.1093/rheumatology/keh663 Sato, 2004, Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis, Rheumatology (Oxford), 43, 1261, 10.1093/rheumatology/keh303 Toussirot, 2009, Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity, Arthritis Res Ther, 11, R101, 10.1186/ar2747 Read, 2006, Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo, J Immunol, 177, 4376, 10.4049/jimmunol.177.7.4376 Roncarolo, 2007, Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans, Nat Rev Immunol, 7, 585, 10.1038/nri2138 Pérez-García, 2007, CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors, Blood, 110, 461, 10.1182/blood-2007-01-069781 Azarian, 2007, Donor CTLA-4 +49 A/G*GG genotype is associated with chronic GVHD after HLA-identical haematopoietic stem-cell transplantations, Blood, 110, 4623, 10.1182/blood-2007-08-106385 Wu, 2009, Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation, Clin Chim Acta, 403, 229, 10.1016/j.cca.2009.03.037 Piccioli, 2010, CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence, Ann Hematol, 89, 613, 10.1007/s00277-009-0885-5 Sellami, 2010, Effect of donor CTLA-4 alleles and haplotypes on graft-versus-host disease occurrence in Tunisian patients receiving a human leukocyte antigen-identical sibling hematopoietic stem cell transplant, Hum Immunol, 72, 139, 10.1016/j.humimm.2010.11.008 Thomas, 1975, Bone-marrow transplantation (second of two parts), N Engl J Med, 292, 895, 10.1056/NEJM197504242921706 Scrucca, 2007, Competing risk analysis using R: an easy guide for clinicians, Bone Marrow Transplant, 40, 381, 10.1038/sj.bmt.1705727 Excoffier, 2005, Arlequin ver. 3.0: An integrated software package for population genetics data analysis, Evol Bioinform Online, 1, 47, 10.1177/117693430500100003 Edinger, 2003, CD4+ CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation, Nat Med, 9, 1144, 10.1038/nm915 Hoffmann, 2002, Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation, J Exp Med, 196, 389, 10.1084/jem.20020399 Coombes, 2005, Regulatory T cells and intestinal homeostasis, Immunol Rev, 204, 184, 10.1111/j.0105-2896.2005.00250.x