Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

Journal of Hepatology - Tập 65 Số 3 - Trang 589-600 - 2016
Giovanni Targher1, Christopher D. Byrne2,3, Amedeo Lonardo4, Giacomo Zoppini1, Corrado Barbui5
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
2Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK
3Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, UK
4Outpatient Liver Clinic and Division of Internal Medicine, Department of Biomedical, Metabolic and Neural Sciences, NOCSAE, Azienda USL and University of Modena and Reggio Emilia, Baggiovara, Modena, Italy
5WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Section of Psychiatry, University of Verona, Verona, Italy

Tóm tắt

Từ khóa


Tài liệu tham khảo

Rinella, 2015, Non-alcoholic fatty liver disease: a systematic review, JAMA, 313, 2263, 10.1001/jama.2015.5370

Lonardo, 2015, Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups, Dig Liver Dis, 47, 997, 10.1016/j.dld.2015.08.004

Anstee, 2013, Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis, Nat Rev Gastroenterol Hepatol, 10, 330, 10.1038/nrgastro.2013.41

Targher, 2010, Risk of cardiovascular disease in patients with non-alcoholic fatty liver disease, N Engl J Med, 363, 1341, 10.1056/NEJMra0912063

Byrne, 2015, NAFLD: a multisystem disease, J Hepatol, 62, S47, 10.1016/j.jhep.2014.12.012

Ballestri, 2014, Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease, World J Gastroenterol, 20, 1724, 10.3748/wjg.v20.i7.1724

Ballestri, 2016, Non-alcoholic fatty liver disease is associated with an almost two-fold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis, J Gastroenterol Hepatol, 31, 936, 10.1111/jgh.13264

Oni, 2013, A systematic review: burden and severity of subclinical cardiovascular disease among those with non-alcoholic fatty liver; should we care?, Atherosclerosis, 230, 258, 10.1016/j.atherosclerosis.2013.07.052

Puchner, 2015, High-risk coronary plaque at coronary CT angiography is associated with non-alcoholic fatty liver disease, independent of coronary plaque and stenosis burden: results from the ROMICAT II trial, Radiology, 274, 693, 10.1148/radiol.14140933

Lonardo, 2015, Non-alcoholic fatty liver disease and risk of cardiovascular disease, Metabolism

Tahan, 2008, Serum gamma-glutamyltranspeptidase distinguishes non-alcoholic fatty liver disease at high risk, Hepatogastroenterology, 55, 1433

Castera, 2013, Noninvasive evaluation of NAFLD, Nat Rev Gastroenterol Hepatol, 10, 666, 10.1038/nrgastro.2013.175

Keramida, 2014, Accumulation of (18)F-FDG in the liver in hepatic steatosis, AJR Am J Roentgenol, 203, 643, 10.2214/AJR.13.12147

Hong, 2014, Hepatic glucose uptake is increased in association with elevated serum γ-glutamyltranspeptidase and triglyceride, Dig Dis Sci, 59, 607, 10.1007/s10620-013-2957-6

Higgins JPT, Green S, (eds.) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available from www.cochrane-handbook.org.

Wells, 2013, Checklists of methodological issues for review authors to consider when including non-randomized studies in systematic reviews, Res Synth Methods, 4, 63, 10.1002/jrsm.1077

Greenland, 1987, Variance estimators for attributable fraction estimates consistent in both large strata and sparse data, Stat Med, 6, 701, 10.1002/sim.4780060607

Higgins, 2002, Quantifying heterogeneity in a meta-analysis, Stat Med, 21, 1539, 10.1002/sim.1186

Furukawa, 2002, Can we individualize the ’number needed to treat’? An empirical study of summary effect measures in meta-analyses, Int J Epidemiol, 31, 72, 10.1093/ije/31.1.72

Egger, 1997, Meta-analysis: principles and procedures, BMJ, 315, 1533, 10.1136/bmj.315.7121.1533

Jepsen, 2003, Prognosis of patients with a diagnosis of fatty liver—a registry-based cohort study, Hepatogastroenterology, 50, 2101

Targher, 2007, Non-alcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients, Diabetes Care, 30, 2119, 10.2337/dc07-0349

Hamaguchi, 2007, Non-alcoholic fatty liver disease is a novel predictor of cardiovascular disease, World J Gastroenterol, 13, 1579, 10.3748/wjg.v13.i10.1579

Haring, 2009, Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyltranspeptidase levels, Hepatology, 50, 1403, 10.1002/hep.23135

Adams, 2010, Non-alcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study, Am J Gastroenterol, 105, 1567, 10.1038/ajg.2010.18

Lazo, 2011, Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study, BMJ, 343, d6891, 10.1136/bmj.d6891

Zhou, 2012, Natural course of non-alcoholic fatty liver disease in southern China: a prospective cohort study, J Dig Dis, 13, 153, 10.1111/j.1751-2980.2011.00571.x

El Azeem, 2013, Association between non-alcoholic fatty liver disease and the incidence of cardiovascular and renal events, J Saudi Heart Assoc, 25, 239, 10.1016/j.jsha.2013.07.004

Pisto, 2014, Fatty liver predicts the risk for cardiovascular events in middle-aged population: a population-based cohort study, BMJ Open, 4, 10.1136/bmjopen-2014-004973

Pickhardt, 2014, Natural history of hepatic steatosis: observed outcomes for subsequent liver and cardiovascular complications, AJR Am J Roentgenol, 202, 752, 10.2214/AJR.13.11367

Wong, 2016, Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: a prospective cohort study, Hepatology, 63, 754, 10.1002/hep.28253

Moon, 2015, Association between non-alcoholic fatty liver disease and carotid artery inflammation evaluated by 18F-fluoro-deoxyglucose positron emission tomography, Angiology, 66, 472, 10.1177/0003319714537872

Ekstedt, 2015, Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up, Hepatology, 61, 1547, 10.1002/hep.27368

Emre, 2015, Impact of non-alcoholic fatty liver disease on myocardial perfusion in nondiabetic patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, Am J Cardiol, 116, 1810, 10.1016/j.amjcard.2015.09.021

Zeb, 2016, Non-alcoholic fatty liver disease and incident cardiac events: The Multi-Ethnic Study of Atherosclerosis, J Am Coll Cardiol, 67, 1965, 10.1016/j.jacc.2016.01.070

Fracanzani, 2016, Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up, Atherosclerosis, 246, 208, 10.1016/j.atherosclerosis.2016.01.016

Kim, 2013, Association between non-invasive fibrosis markers and mortality among adults with non-alcoholic fatty liver disease in the United States, Hepatology, 57, 1357, 10.1002/hep.26156

Ghouri, 2010, Liver enzymes, non-alcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data, Hepatology, 52, 1156, 10.1002/hep.23789

Musso, 2011, Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity, Ann Med, 43, 617, 10.3109/07853890.2010.518623

Lu, 2013, Independent association between non-alcoholic fatty liver disease and cardiovascular disease: a systematic review and meta-analysis, Int J Endocrinol, 2013, 124958, 10.1155/2013/124958

Younossi, 2015, Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence and outcomes, Hepatology

Stepanova, 2012, Independent association between non-alcoholic fatty liver disease and cardiovascular disease in the US population, Clin Gastroenterol Hepatol, 10, 646, 10.1016/j.cgh.2011.12.039

Younossi, 2013, In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not, Metabolism, 62, 352, 10.1016/j.metabol.2012.08.005

Wong, 2011, Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease, Gut, 60, 1721, 10.1136/gut.2011.242016

Ekstedt, 2006, Long-term follow-up of patients with NAFLD and elevated liver enzymes, Hepatology, 44, 865, 10.1002/hep.21327

Soderberg, 2010, Decreased survival of subjects with elevated liver function tests during a 28-year follow-up, Hepatology, 51, 595, 10.1002/hep.23314

Matteoni, 1999, Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity, Gastroenterology, 116, 1413, 10.1016/S0016-5085(99)70506-8

Rafiq, 2009, Long-term follow-up of patients with non-alcoholic fatty liver, Clin Gastroenterol Hepatol, 7, 234, 10.1016/j.cgh.2008.11.005

Adams, 2005, The natural history of non-alcoholic fatty liver disease: a population-based cohort study, Gastroenterology, 129, 113, 10.1053/j.gastro.2005.04.014

Angulo, 2015, Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with non-alcoholic fatty liver disease, Gastroenterology, 149, 389, 10.1053/j.gastro.2015.04.043

Byrne, 2014, Ectopic fat, insulin resistance, and non-alcoholic fatty liver disease: implications for cardiovascular disease, Arterioscler Thromb Vasc Biol, 34, 1155, 10.1161/ATVBAHA.114.303034

VanWagner, 2015, Association of non-alcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: a population-based study, Hepatology, 62, 773, 10.1002/hep.27869

Targher, 2013, Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes, PLoS One, 8, 10.1371/journal.pone.0057183

Mantovani, 2015, Heart valve calcification in patients with type 2 diabetes and non-alcoholic fatty liver disease, Metabolism, 64, 879, 10.1016/j.metabol.2015.04.003

Lonardo, 2015, Diagnosis and management of cardiovascular risk in non-alcoholic fatty liver disease, Expert Rev Gastroenterol Hepatol, 9, 629, 10.1586/17474124.2015.965143

Singh, 2015, Fibrosis progression in non-alcoholic fatty liver vs. non-alcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies, Clin Gastroenterol Hepatol, 13, 643, 10.1016/j.cgh.2014.04.014