Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system

Proceedings of the National Academy of Sciences of the United States of America - Tập 112 Số 22 - 2015
Aljoscha Nern1, Barret D. Pfeiffer1, Gerald M. Rubin1
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147-2408

Tóm tắt

Significance Nervous systems contain vast numbers of neurons with diverse shapes and complex spatial relationships. We describe new genetic tools for the efficient visualization by light microscopy of individual neurons and their relative positions in Drosophila . The application of these methods to the visual system revealed an unexpected diversity of cell-type–specific arrangements of neuronal processes within a single brain region. This wide range of stereotyped cell arrangements provides distinct circuit elements for processing visual information and implies the existence of a surprisingly large number of genetic programs that produce these arrangements during development.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 112 Số 22

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