An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience

Burroughs, 2012, Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures, Journal of Neuroscience Methods, 203, 141, 10.1016/j.jneumeth.2011.09.007 Decker, 1988, A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity, Journal of Immunological Methods, 115, 61, 10.1016/0022-1759(88)90310-9 Kaja, 2011, Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors, Neuroscience, 175, 281, 10.1016/j.neuroscience.2010.11.010 Kendig, 2007, Inactivation of lactate dehydrogenase by several chemicals: Implications for in vitro toxicology studies, Toxicology in Vitro: An International Journal Published in Association with BIBRA, 21, 125, 10.1016/j.tiv.2006.08.004 Nachlas, 1960, The determination of lactic dehydrogenase with a tetrazolium salt, Analytical Biochemistry, 1, 317, 10.1016/0003-2697(60)90029-4 Stoddart, 2011, Cell viability assays: Introduction, 1 Vega-Avila, 2011, An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells, Proceedings of the Western Pharmacology Society, 54, 10