New advances in CMV and immunosenescence

Barton, 2007, Herpesvirus latency confers symbiotic protection from bacterial infection, Nature, 447, 326, 10.1038/nature05762 Bughio, 2013, An endothelial cell-specific requirement for the UL133–UL138 locus of human cytomegalovirus for efficient virus maturation, J. Virol., 87, 3062, 10.1128/JVI.02510-12 Cicin-Sain, 2012, Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging, PLoS Pathog., 8, e1002849, 10.1371/journal.ppat.1002849 Derhovanessian, 2013, Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people, Age (Dordr), 35, 1387, 10.1007/s11357-012-9425-7 Gow, 2013, Cytomegalovirus infection and cognitive abilities in old age, Neurobiol. Aging, 34, 1846, 10.1016/j.neurobiolaging.2013.01.011 Griffiths, 2013, Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA, J. Immunol., 190, 5363, 10.4049/jimmunol.1203267 Hertoghs, 2010, Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation, J. Clin. Invest., 120, 4077, 10.1172/JCI42758 Kuparinen, 2013, Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis, Exp. Gerontol., 48, 305, 10.1016/j.exger.2012.12.010 Lozza, 2005, Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells, Eur. J. Immunol., 35, 1795, 10.1002/eji.200526023 Mekker, 2012, Immune senescence: relative contributions of age and cytomegalovirus infection, PLoS Pathog., 8, e1002850, 10.1371/journal.ppat.1002850 Muntasell, 2013, Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host–pathogen interaction, Eur. J. Immunol., 43, 1133, 10.1002/eji.201243117 Pawelec, 2010, Immunosenescence and Cytomegalovirus: where do we stand after a decade?, Immun. Ageing, 7, 13, 10.1186/1742-4933-7-13 Rahbar, 2013, Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival, J. Clin. Virol., 57, 36, 10.1016/j.jcv.2012.12.018 Remmerswaal, 2012, Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes, Blood, 119, 1702, 10.1182/blood-2011-09-381574 Roux, 2013, Differential impact of age and cytomegalovirus infection on the gammadelta T cell compartment, J. Immunol., 191, 1300, 10.4049/jimmunol.1202940 Savva, 2013, Cytomegalovirus infection is associated with increased mortality in the older population, Aging Cell, 12, 381, 10.1111/acel.12059 Smithey, 2012, Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life, J. Immunol., 189, 5356, 10.4049/jimmunol.1201867 Solana, 2012, CMV and Immunosenescence: from basics to clinics, Immun. Ageing, 9, 23, 10.1186/1742-4933-9-23 Stragliotto, 2013, Effects of valganciclovir as an add-on therapy in patients with cytomegalovirus-positive glioblastoma: a randomized, double-blind, hypothesis-generating study, Int. J. Cancer, 133, 1204, 10.1002/ijc.28111 Strandberg, 2009, Cytomegalovirus antibody level and mortality among community-dwelling older adults with stable cardiovascular disease, JAMA, 301, 380, 10.1001/jama.2009.4 Sylwester, 2005, Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects, J. Exp. Med., 202, 673, 10.1084/jem.20050882 Terrazzini, 2013, A novel CMV-induced regulatory type T-cell subset increases in older life and links virus-specific immunity to vascular pathology, J. Infect. Dis. Umashankar, 2014, Antagonistic determinants controlling replicative and latent states of human cytomegaovirus infection, J Virol., 10.1128/JVI.03506-13 Vaes, 2010, The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium, BMC Geriatr., 10, 39, 10.1186/1471-2318-10-39 Wall, 2013, Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease, PLoS ONE, 8, e55686, 10.1371/journal.pone.0055686 Wang, 2010, Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study, Am. J. Epidemiol., 171, 1144, 10.1093/aje/kwq062 Welzl, 2014, How immunosuppressive therapy affects T cells from kidney transplanted patients of different age: the role of latent CMV infection, Clin. Exp. Immunol., 176, 112, 10.1111/cei.12205 Willcox, 2012, Cytomegalovirus and tumor stress surveillance by binding of a human gammadelta T cell antigen receptor to endothelial protein C receptor, Nat. Immunol., 13, 872, 10.1038/ni.2394 Wills, 2011, Report from the second cytomegalovirus and immunosenescence workshop, Immun. Ageing, 8, 10, 10.1186/1742-4933-8-10 Wolmer-Solberg, 2013, Frequent detection of human cytomegalovirus in neuroblastoma: a novel therapeutic target?, Int. J. Cancer., 133, 2351, 10.1002/ijc.28265