Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential

Cellular and Molecular Life Sciences - Tập 73 - Trang 3311-3321 - 2016
Miaohua Mo1,2, Shan Wang1,2, Ying Zhou1,2, Hong Li3, Yaojiong Wu2
1School of Life Sciences, Tsinghua University, Beijing, China
2The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
3Department of General Surgery, Qingdao Municipal Hospital, Qingdao, China

Tóm tắt

Mesenchymal stem cells (MSC) are capable of differentiating into cells of multiple cell lineages and have potent paracrine effects. Due to their easy preparation and low immunogenicity, MSC have emerged as an extremely promising therapeutic agent in regenerative medicine for diverse diseases. However, MSC are heterogeneous with respect to phenotype and function in current isolation and cultivation regimes, which often lead to incomparable experimental results. In addition, there may be specific stem cell subpopulations with definite differentiation capacity toward certain lineages in addition to stem cells with multi-differentiation potential. Recent studies have identified several subsets of MSC which exhibit distinct features and biological activities, and enhanced therapeutic potentials for certain diseases. In this review, we give an overview of these subsets for their phenotypic, biological and functional properties.

Tài liệu tham khảo

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