Heart rate and autonomic biomarkers distinguish convulsive epileptic vs. functional or dissociative seizures

Devinsky, 2011, Differentiating between nonepileptic and epileptic seizures, Nat Rev Neurol., 7, 210, 10.1038/nrneurol.2011.24 Reuber, 2017, Understanding psychogenic nonepileptic seizures-phenomenology, semiology and the Integrative, Cogn Model Seiz, 44, 199, 10.1016/j.seizure.2016.10.029 Salpekar, 2019, Seizures, nonepileptic events, trauma, anxiety, or all of the above epilepsy currents, Am Epilepsy Soc, 19, 29 Yeom, 2021, Myths and truths about pediatric psychogenic nonepileptic seizures, Clin Exp Pediatr, 64, 251, 10.3345/cep.2020.00892 Bompaire, 2021, PNES epidemiology: what is known, what is new?, Eur J Trauma Dissociation, 5, 10.1016/j.ejtd.2019.100136 Bermeo-Ovalle, 2021, Can treating patients with PNES lower the risk of sudden unexpected death? Epilepsy currents, Am Epilepsy Soc, 21, 87 Mungen, 2010, Autonomic nervous system functions in interictal and postictal periods of nonepileptic psychogenic seizures and its comparison with epileptic seizures, Seizure, 19, 269, 10.1016/j.seizure.2010.04.002 Villagran, 2021, Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: a 10-year population-based study, Epilepsia, 62, 1528, 10.1111/epi.16949 Nightscales, 2020, Mortality in patients with psychogenic nonepileptic seizures, Neurology, 95, e643, 10.1212/WNL.0000000000009855 Lehn, 2021, Psychogenic nonepileptic seizures treated as epileptic seizures in the emergency department, Epilepsia, 62, 2416, 10.1111/epi.17038 Jungilligens, 2021, Misdiagnosis of prolonged psychogenic non-epileptic seizures as status epilepticus: epidemiology and associated risks, J. Neurol. Neurosurg. Psychiatr., 92, 1341, 10.1136/jnnp-2021-326443 Couderc, 2012, Genotype- and sex-specific QT-RR relationship in the type-1 long-QT syndrome, J Am Heart Assoc, 1, 10.1161/JAHA.112.000570 Huikuri, 2013, Heart rate variability in risk stratification of cardiac patients, Prog Cardiovasc Dis, 56, 153, 10.1016/j.pcad.2013.07.003 Shaffer, 2017, An overview of heart rate variability metrics and norms, Front Public Health, 5, 258, 10.3389/fpubh.2017.00258 1996, Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, Circulation, 93, 1043, 10.1161/01.CIR.93.5.1043 Anzellotti, 2020, psychogenic non-epileptic seizures and pseudo-refractory epilepsy, a management challenge, Front Neurol, 11, 461, 10.3389/fneur.2020.00461 Galimberti, 2003, Patients with psychogenic nonepileptic seizures, alone or epilepsy-associated, share a psychological profile distinct from that of epilepsy patients, J Neurol, 250, 338, 10.1007/s00415-003-1009-0 Surges, 2010, Pathologic cardiac repolarization in pharmacoresistant epilepsy and its potential role in sudden unexpected death in epilepsy: a case-control study, Epilepsia, 51, 233, 10.1111/j.1528-1167.2009.02330.x Surges, 2010, Too long or too short? New insights into abnormal cardiac repolarization in people with chronic epilepsy and its potential role in sudden unexpected death, Epilepsia, 51, 738, 10.1111/j.1528-1167.2010.02571.x Ergul, 2013, QT and P wave dispersion and heart rate variability in patients with Dravet syndrome, Acta Neurol Belg, 113, 161, 10.1007/s13760-012-0140-z Strzelczyk, 2011, Postictal increase in T-wave alternans after generalized tonic-clonic seizures, Epilepsia, 52, 2112, 10.1111/j.1528-1167.2011.03266.x Verrier, 2016, Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial, Epilepsy Behav: E&B, 62, 85, 10.1016/j.yebeh.2016.06.016 Moridani, 2017, Heart rate variability as a biomarker for epilepsy seizure prediction, Bratisl Lek Listy, 118, 3 Reinsberger, 2012, Pre- and postictal, not ictal, heart rate distinguishes complex partial and psychogenic nonepileptic seizures, Epilepsy Behav: E&B, 23, 68, 10.1016/j.yebeh.2011.10.008 Eggleston, 2014, Ictal tachycardia: the head-heart connection, Seizure, 23, 496, 10.1016/j.seizure.2014.02.012 Mukherjee, 2009, Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies, Epilepsy Res, 85, 261, 10.1016/j.eplepsyres.2009.03.021 Devinsky, 2016, Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention, Lancet Neurol, 15, 1075, 10.1016/S1474-4422(16)30158-2 Ponnusamy, 2012, Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures, Epilepsia, 53, 1314, 10.1111/j.1528-1167.2012.03518.x Laborde, 2017, Heart rate variability and cardiac vagal tone in psychophysiological research - recommendations for experiment planning, data analysis, and data reporting, Front Psychol, 8, 213, 10.3389/fpsyg.2017.00213 Jeppesen, 2016, Comparing maximum autonomic activity of psychogenic non-epileptic seizures and epileptic seizures using heart rate variability, Seizure, 37, 13, 10.1016/j.seizure.2016.02.005 Ponnusamy, 2011, Heart rate variability measures as biomarkers in patients with psychogenic nonepileptic seizures: potential and limitations, Epilepsy Behav: E&B, 22, 685, 10.1016/j.yebeh.2011.08.020 Myers, 2018, Heart rate variability in epilepsy: a potential biomarker of sudden unexpected death in epilepsy risk, Epilepsia, 59, 1372, 10.1111/epi.14438 Asadi-Pooya, 2019, Semiological classification of psychogenic nonepileptic seizures: a systematic review and a new proposal, Epilepsy Behav: E&B, 100, 10.1016/j.yebeh.2019.07.013 Garg, 2021, Classification and comparative analysis of psychogenic nonepileptic seizures (PNES) semiology based on video-electroencephalography (VEEG), Epilepsy Behav: E&B, 115, 10.1016/j.yebeh.2020.107697 Romigi, 2020, Heart rate variability parameters during psychogenic non-epileptic seizures: comparison between patients with pure PNES and comorbid, Epilepsy Front Neurol, 11, 713, 10.3389/fneur.2020.00713 Opherk, 2002, Ictal heart rate differentiates epileptic from non-epileptic seizures, Neurology, 58, 636, 10.1212/WNL.58.4.636 MathWorks. MatLab R2023a perfcurve: receiver operating characteristic (ROC) curve or other performance curve for classifier output. Available at: https://www.mathworks.com/help/stats/perfcurve.html#bunsogv-OPTROCPT. Accessed 8/14/2023. Sundararajan, 2016, Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: a systematic review, Seizure, 35, 11, 10.1016/j.seizure.2015.12.011 Kusmakar, 2019, Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures, Epilepsia, 60, 165, 10.1111/epi.14619 Gledhill, 2021, Association of epileptic and nonepileptic seizures and changes in circulating plasma proteins linked to neuroinflammation, Neurology, 96, e1443, 10.1212/WNL.0000000000011552 Ahl, 2023, Immune response in blood before and after epileptic and psychogenic non-epileptic seizures, Heliyon, 9, e13938, 10.1016/j.heliyon.2023.e13938 Deli, 2021, Distinguishing psychogenic nonepileptic, mixed, and epileptic seizures using systemic measures and reported experiences, Epilepsy Behav: E&B, 116, 10.1016/j.yebeh.2020.107684 Tatum, 2020, Assessment of the predictive value of outpatient smartphone videos for diagnosis of epileptic seizures, JAMA Neurol, 77, 593, 10.1001/jamaneurol.2019.4785 Karakas, 2021, Home video prediction of epileptic vs. nonepileptic seizures in US veterans, Epilepsy Behav: E&B, 117, 10.1016/j.yebeh.2021.107811 Zsom, 2019, Ictal autonomic activity recorded via wearable-sensors plus machine learning can discriminate epileptic and psychogenic nonepileptic seizures, Annu Int Conf IEEE Eng Med Biol Soc, 2019, 3502 Dworetzky, 2018, Global warming for psychogenic nonepileptic seizures? Report from ILAE climate survey epilepsy currents, Am Epilepsy Soc, 18, 231 Hingray, 2018, Access to diagnostic and therapeutic facilities for psychogenic nonepileptic seizures: an international survey by the ILAE, PNES Task Force Epilepsia, 59, 203, 10.1111/epi.13952 Devinsky, 2004, Effects of seizures on autonomic and cardiovascular function epilepsy currents, Am Epilepsy Soc, 4, 43 Lotufo, 2012, A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs, Epilepsia, 53, 272, 10.1111/j.1528-1167.2011.03361.x Bruno, 2018, Pre-ictal heart rate changes: a systematic review and meta-analysis, Seizure, 55, 48, 10.1016/j.seizure.2018.01.003 Indranada, 2019, Preictal autonomic dynamics in psychogenic nonepileptic seizures, Epilepsy Behav: E&B, 92, 206, 10.1016/j.yebeh.2018.12.026 van der Kruijs, 2016, Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: analysis of heart rate variability, Epilepsy Behav: E&B, 54, 14, 10.1016/j.yebeh.2015.10.014 LaFrance, 2013, Minimum requirements for the diagnosis of psychogenic nonepileptic seizures: a staged approach: a report from the International League Against Epilepsy Nonepileptic Seizures, Task Force Epilepsia, 54, 2005, 10.1111/epi.12356