Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature

Adham, 1992, The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1Dβ receptor, Molec. Pharmac., 41, 1 Adham, 1993, Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylyl cyclase, 89, 408 Adham, 1993, Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways, Naunyn Schmiedeberg's Archs. Pharmac., 348, 566, 10.1007/BF00167231 Alhaider, 1991, Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA, J. Neursci., 11, 1881, 10.1523/JNEUROSCI.11-07-01881.1991 Amlaiky, 1992, Isolation of a mouse 5-HT1E-like serotonin receptor expressed predominantly in hippocampus, J. Biol. Chem., 267, 19761, 10.1016/S0021-9258(19)88617-9 Andrade, 1991, 5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus, J. Pharmac. Exp. Ther., 257, 930 Andrade, 1986, A G protein couples serotonin and GABAg receptors to the same channels in hippocampus, Science, 234, 1261, 10.1126/science.2430334 Andrew, 1988, Neuropharmacology of emesis induced by anticancer therapy, Trends Pharmac. Sci., 9, 334, 10.1016/0165-6147(88)90106-X Ashby, 1990, Functional characterisation of 5-HT3-like receptors in the rat medial perfrontal cortex: biochemical and electro-physiological studies, Eur. J. Pharmac., 183, 1958, 10.1016/0014-2999(90)92307-5 Bach, 1993, Structure, functional expression and spatial distribution of a cloned cDNA encoding a rat 5-HT1D-like receptor, J. Recep. Res., 13, 479, 10.3109/10799899309073674 Barnes, 1989, 5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue, Nature, 338, 762, 10.1038/338762a0 Barnes, 1992, Behavioural pharmacology of 5-HT3 receptor ligands, Neurosci. Biobehav. Rev., 16, 107, 10.1016/S0149-7634(05)80057-0 Baxter, 1991, 5-Hydroxytryptamine receptors mediate relaxation of the rat oesophageal tunica murcularis mucosae, Naunyn-Schmiedeberg's Archs Pharmac., 343, 439, 10.1007/BF00169544 Beer, 1992, An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carbox-amidotryptamine and sumatriptan in the central nervous system of seven species, Eur. J. Pharmac., 213, 193, 10.1016/0014-2999(92)90681-S Beer, 1993, L-694,247, a potent 5-HT1D receptor agonist, Br. J. Pharmac., 110, 1196, 10.1111/j.1476-5381.1993.tb13941.x Blandina, 1988, Activation of a 5-HT3 receptor releases dopamine from rat striatal slice, Eur. J. Pharmac., 155, 349, 10.1016/0014-2999(88)90528-6 Blandina, 1991, Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices, J. Pharmac. Exp. Ther., 256, 341 Blauw, 1988, Serotonin-induced vasodilation in the human forearm is antagonised by the selective 5-HT3 receptor antagonist ICS 205-930, Life Sci., 43, 1441, 10.1016/0024-3205(88)90255-X Blier, 1991, Termination serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins, Naunyn-Schmiedeberg's Archs Pharmac., 344, 160, 10.1007/BF00167213 Bockaert, 1991, Pharmacological characterisation of brain 5-HT4 receptors: relationship between the effect of indole, benzamide and azabicycloalkylebenzimidazolone derivatives, 220 Boddeke, 1992, Agonist effects at putative central 5-HT4 receptors in rat hippocampus by R(+)- and S(−)-zacopride: no evidence for stereo-selectivity, Neurosci. Lett., 134, 261, 10.1016/0304-3940(92)90530-K Bodelsson, 1993, Endothelial relaxing 5-hydroxytryptamine receptors in the rat jugular vein: similarity with the 5-hydroxytryptamine1C receptor, J. Pharmac. Exp. Ther., 264, 709 Bradley, 1986, Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine, Neuropharmacology, 25, 563, 10.1016/0028-3908(86)90207-8 Branchek, 1984, Enteric receptors for 5-hydroxytryptamine, Brain Res., 324, 107, 10.1016/0006-8993(84)90627-9 Branchek, 1990, [3H]OB (4-bromo-2,5-dimethoxyphenylpropylamine) and [3H]ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor, Molec. Pharmac., 38, 604 Branchek, 1994, Autoradiographic localisation of 5-HT7 and its mRNA in rat CNS by radioligand binding and in situ hybridisation histochemistry, Br. J. Pharmac., 111, 100P Bruinvels, 1994, Localisation of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain, Neuropharmacology, 33, 367, 10.1016/0028-3908(94)90067-1 Buzzi, 1991, Further characterisation of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasion in rat dura mater, Br. J. Pharmac., 103, 1421, 10.1111/j.1476-5381.1991.tb09805.x Chambard, 1990, Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence, Nucleic Acids Res., 18, 5282, 10.1093/nar/18.17.5282 Clarke, 1989, The 5-HT4 receptor: naughty but nice, Trends Pharmac. Sci., 10, 385, 10.1016/0165-6147(89)90177-6 Conn, 1986, Agonist-induced phosphoinositide hydrolysis in choroid plexus, J. Neurochem., 47, 1754, 10.1111/j.1471-4159.1986.tb13085.x Connell, 1989, 5-Hydroxytryptamine depolarises neonatal rat motoneurones through a receptor unrelated to an identified binding site, Neuropharmacology, 28, 625, 10.1016/0028-3908(89)90142-1 Costall, 1987, Effects of the 5-HT3 receptor antagonist GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain, Br. J. Pharmac., 92, 881, 10.1111/j.1476-5381.1987.tb11394.x Craig, 1990, 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced densensitisation as a discriminative tool for the 6-ht3 and putative 5-HT4 receptors in guinea-pig ileum, Naunyn-Schmiedeberg's Archs Pharmac., 342, 9, 10.1007/BF00178965 Craig, 1990, Pharmcological characterisation of a neuronal receptor for 5-hydroxytryptamine in guinea-pig ileum with properties similar to the 5-hydroxytryptamine4 receptor, J. Pharmac. Exp. Ther., 252, 1378 Craig, 1993, 5-HT1B receptors mediate potent contractile responses to 5-HT in rat caudal artery, Br. J. Pharmac., 109, 609, 10.1111/j.1476-5381.1993.tb13615.x Dumuis, 1988, A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonised by ICS 205,930, Eur. J. Pharmac., 146, 187, 10.1016/0014-2999(88)90503-1 Dumuis, 1988, A non-classical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system, Molec. Pharmac., 34, 880 Edwards, 1991, Effects of 5-hydroxytryptamine3 receptor agonists on phosphoinositide hydrolysis in the rat frontocingulate and entorhinal cortices, J. Pharmac. Exp. Ther., 256, 1025 Elswood, 1991, Identification of putative 5-HT4 receptors in guinea-pig ascending colon, Eur. J. Pharmac., 196, 149, 10.1016/0014-2999(91)90421-L Engel, 1986, Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites, Naunyn-Schmiedeberg's Archs Pharmac., 332, 1, 10.1007/BF00633189 Erlander, 1993, Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain, 90, 3452 Fagni, 1992, The 5-HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase, Br. J. Pharmac., 105, 973, 10.1111/j.1476-5381.1992.tb09087.x Fargin, 1989, Effector coupling mechanisms of the cloned 5-HT1A receptor, J. Biol. Chem., 264, 14848, 10.1016/S0021-9258(18)63778-0 Felder, 1990, Serotonin stimulates phospholipase A-2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositol phospholipid hydrolysis, 87, 2187 Feniuk, 1981, Analysis of the mechanism of 5-hydroxytryptamine-induced vasopressor responses in ganglion-blocked anaesthetized dogs, J. Pharm. Pharmac., 33, 155, 10.1111/j.2042-7158.1981.tb13739.x Flynn, 1992, SC-53116: The first selective agonist at the newly identified serotonin 5-HT4 receptor sub-type, J. Med. Chem., 35, 1486, 10.1021/jm00086a019 Foguet, 1992, Cloning and functional expression of the rat stomach fundus serotonin receptor, EMBO J., 11, 3481, 10.1002/j.1460-2075.1992.tb05427.x Forbes, 1993, N-(1-methyl-5-indolyl)-N'-(3-pyridyl)-urea hydrochloride: the first selective 5-HT1C receptor antagonist, J. Med. Chem., 36, 1104, 10.1021/jm00060a019 Ford, 1992, 5-Hydroxytryptamine stimulates cyclic AMP formation in the tunica muscularis mucosae of the rat oesophagus via 5-HT4 receptors, Eur. J. Pharmac., 211, 117, 10.1016/0014-2999(92)90272-6 Fozard, 1984, Neuronal 5-HT receptors in the periphery, Neuropharmacology, 23, 1473, 10.1016/0028-3908(84)90091-1 Fozard, 1990, Agonists and antagonists of 5-HT3 receptors, 101 Fozard, 1992, 5-HT1C receptor agonism as an initiating event in migraine, 200 Fozard, 1992, 5-HT3 receptors in the context of the multiplicity of 5-HT receptors, 1 Fozard, 1985, 8-OH-DPAT inhibits transmitter release from guinea-pig enteric cholinergic neurones by activating 5-HT1A receptors, Br. J. Pharmac., 86, 601P Frazer, 1990, Subtypes of receptors for serotonin, A. Rev. Pharmac. Toxic., 30, 307, 10.1146/annurev.pa.30.040190.001515 Gaddum, 1957, Two kinds of tryptamine receptors, Br. J. Pharmac. Chemother., 12, 323, 10.1111/j.1476-5381.1957.tb00142.x Galzin, 1991, Modulation of 5-HT release by presynaptic inhibitory and facilitatory 5-HT receptors in brain slices, 82, 59 Glennon, 1991, Serotonin receptors and their ligands: a lack of selective agents, Pharmac. Biochem. Behav., 40, 1009, 10.1016/0091-3057(91)90121-H Glusa, 1992, Evidence for 5-HT1C receptor-mediated endothelium-dependent relaxation of porcine pulmonary arteries in vitro, 168 Glusa, 1993, Endothelium-dependent relaxations of porcine pulmonary arteries via 5-HT1C-like receptors, Naynyn -Schmiedeberg's Archs Pharmac., 347, 471, 10.1007/BF00166737 Grossman, 1993, Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain, Br. J. Pharmac., 109, 618, 10.1111/j.1476-5381.1993.tb13617.x Gupta, 1992, An endothelial 5-HT receptor that mediates relaxation in guinea-pig jugular vein resembles the 5-HT1D, subtype, Br. J. Pharmac., 106, 703, 10.1111/j.1476-5381.1992.tb14398.x Hamel, 1993, Expression of mRNA for the serotonin 5-hydroxytryptamine1Dβ receptor subtype in human and bovine cerebral arteries, Molec. Pharmac., 44, 242 Harel-Dupas, 1991, The inhibitory effect of TFMPP on 3H]acetylcholine release in guinea-pig hippocampal synaptosomes is mediated by a 5-HT1 receptor distinct from 1A-subtype, 1B-subtype and 1C-subtype, J. Neurochem., 56, 221, 10.1111/j.1471-4159.1991.tb02584.x Hartig, 1990, The molecular biology of serotonin receptors: An overview, Newopsychopharmacology, 3, 335 Hartig, 1989, Molecular biology of 5-HT receptors, Trends. Pharmac. Sci., 10, 64, 10.1016/0165-6147(89)90080-1 Heuring, 1987, Characterisation of a novel [3H]5-HT binding site subtype in bovine brain membranes, J. Neurosci., 7, 894, 10.1523/JNEUROSCI.07-03-00894.1987 Hoyer, 1988, Molecular pharmacology and biology of 5-HT1C receptors, Trends Pharmac. Sci., 9, 89, 10.1016/0165-6147(88)90174-5 Hoyer, 1986, Serotonin receptors in the human brain II. Characterisation and autoradiographic localisation of 5-HT1C and 5-HT2 recognition sites, Brain Res., 376, 97, 10.1016/0006-8993(86)90903-0 Hoyer, 1989, 5-HT1C receptor-mediated stimulation of inositol phosphate production in pig choroid plexus; a pharmacological characterisation, Naunyn-Schmiedeberg's Archs Pharmac., 339, 252, 10.1007/BF00173573 Hoyer, 1994, The IUPHAR classification of receptors for 5-hydroxytryptamine (serotonin), Pharmac. Rev. Humphrey, 1993, A proposed new nomenclature for 5-HT receptors, Trends. Pharmac. Sci., 14, 233, 10.1016/0165-6147(93)90016-D Julius, 1988, Molecular characterisation of a functional cDNA encoding the serotoninic receptor, Science, 214, 558, 10.1126/science.3399891 Kao, 1992, Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology, FEBS Lett., 307, 324, 10.1016/0014-5793(92)80705-L Kaumann, 1991, 5-HT4-like receptors in mammalian atria, J. Neural. Trans., 34, 195 Kaumann, 1990, A 5-hydroxytryptamine receptor in human atrium, Br. J. Pharmac., 100, 879, 10.1111/j.1476-5381.1990.tb14108.x Kenakin, 1992, Definition of pharmacological receptors, Pharmac. Rev., 44, 351 Kennett, 1988, Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU24969 only requires 5-HT1B receptors, Psychopharmacologia, 96, 93, 10.1007/BF02431539 Kennet, 1989, Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists, Eur. J. Pharmac., 164, 445, 10.1016/0014-2999(89)90252-5 Kilpatrick, 1990, -HT3 receptors, Med. Res. Rev., 10, 441, 10.1002/med.2610100404 Kursar, 1992, Molecular cloning, functional expression and pharmacological characterisation of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus, Molec. Pharmac., 42, 549 Lefebvre, 1992, Serotonin-induced stimulation of Cortisol secretion from human adrenocortical tissue is mediated through activation of a serotonin4 receptor subtype, Neuroscience, 47, 999, 10.1016/0306-4522(92)90047-6 Leff, 1987, Differential classification of vascular smooth muscle and endothelial cell 5-HT receptors by use of tryptamine analogues, Br. J. Pharmac., 91, 321, 10.1111/j.1476-5381.1987.tb10287.x Leonhardt, 1989, Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with the GTP-binding protein, J. Neurochem., 53, 465, 10.1111/j.1471-4159.1989.tb07357.x Liu, 1991, Cell-specific signalling of the 5-HT1A receptor, J. Biol. Chem., 266, 23689, 10.1016/S0021-9258(18)54339-8 Loric, 1993, New mouse 5-HT2-like receptor expression in brain, heart and intestine, FEBS Lett., 312, 203, 10.1016/0014-5793(92)80936-B Lovenberg, 1993, A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms, Neuron, 11, 449, 10.1016/0896-6273(93)90149-L Lübbert, 1987, cDNA cloning of a serotonin 5-HT1C receptor by electro-physiological assays of mRNA-injected xenopus occytes, 84, 4322 Lucki, 1992, 5-HT1 receptors and behaviour, Neurosci. Behav. Rev., 16, 83, 10.1016/S0149-7634(05)80055-7 Macor, 1990, 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl) indole, J. Med. Chem., 33, 2087, 10.1021/jm00170a007 Maenhaut, 1991, The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor, Biochem. Biophys. Res. Commun., 180, 1460, 10.1016/S0006-291X(05)81360-9 Malgouris, 1993, Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. In vitro and ex vivo selectivity profile, Eur. J. Pharmac., 233, 29, 10.1016/0014-2999(93)90345-I Maricq, 1991, Primary structure and functional expression of the 5-HT3 receptor, a serotonin-gated ion channel, Science, 254, 432, 10.1126/science.1718042 Maroteaux, 1992, The mouse 5-HT1B serotonin receptor: cloning, functional expression and localisation in motor control centers, 89, 3020 Martin, 1994, Vascular receptors for 5-hydroxytryptamine. Distribution, Function and Classification, J. Pharmac. Ther., 10.1016/0163-7258(94)90048-5 Martin, 1993, Further characterisation of an atypical 5-HT receptor mediating endothelium-dependent vasorelaxation, Br. J. Pharmac., 110, 137P Matsubara, 1991, CP-93,129, a potent and selective 5-HT1B receptor agonist, blocker neurogenic plasma extravasation within rat, but not guinea-pig dura mater, Br. J. Pharmac., 104, 3, 10.1111/j.1476-5381.1991.tb12374.x Matthes, 1993, Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression and chromosomal localisation, Molec. Pharmac., 43, 313 Maura, 1986, Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release, Eur. J. Pharmac., 129, 333, 10.1016/0014-2999(86)90443-7 Maura, 1988, Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HTh1 and 5-HT2 receptors, Eur. J. Pharmac., 145, 31, 10.1016/0014-2999(88)90345-7 McAllister, 1992, Molecular cloning of a serotonin receptor from human brain (5-HT1E): a fifth 5-HT1-like sub-type, 89, 5517 Meyerhof, 1993, A novel rat serotonin receptor: primary structure, pharmacology, and expression pattern in distinct brain regions, DNA Cell Biol., 12, 401, 10.1089/dna.1993.12.401 Molderings, 1987, Inhibition of noradrenaline release in the rat vena cava via presynaptic 5-HT1B receptors, Naunyn -Schmiedeberg's Archs. Pharmac., 336, 245, 10.1007/BF00172673 Molineaux, 1989, 5-HT1C receptor is a prominent serotonin receptor subtype in the central nervous system, 86, 6793 Monsma, 1993, Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs, Molec. Pharmac., 43, 320 Muramatsu, 1988, Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminals of hippocampus of rat, Neuropharmacology, 27, 603, 10.1016/0028-3908(88)90181-5 Muramatsu, 1988, 5-HT2, antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices, Eur. J. Pharmac., 153, 89, 10.1016/0014-2999(88)90591-2 Mylecharane, 1990, Agonists and antagonists of 5-HT2 receptors, 81 North, 1989, 5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones, J. Physiol., 417, 1, 10.1113/jphysiol.1989.sp017786 Oksenberg, 1992, A single aminoacid difference confers major pharmacological variation between human and rodent 5-HT1B receptors, Nature, 360, 161, 10.1038/360161a0 Pazos, 1987, Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors, Neuroscience, 21, 123, 10.1016/0306-4522(87)90327-7 Peroutka, 1993, 5-Hydroxytryptamine receptors, J. Neurochem., 60, 408, 10.1111/j.1471-4159.1993.tb03166.x Perren, 1991, Vascular 5-HT1-like receptor that mediates contractions of the dog isolated saphenous vein and carotid arterial vaso-constriction in anaesthetised dogs are not of the 5-HT1A or 5-HT1D subtype, Br. J. Pharmac., 102, 191, 10.1111/j.1476-5381.1991.tb12152.x Peters, 1991, Characterisation of 5-HT3 receptor-mediated electrical responses in nodose ganglion neurones and clonal neuroblastoma cells maintained in culture, 84 Plassat, 1993, Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase, Molec. Pharmac., 44, 229 Plassat, 1992, The mouse 5-HT5 receptor reveals a remarkable heterogeneity within the 5-HT1D receptor family, EMBO J., 11, 4779, 10.1002/j.1460-2075.1992.tb05583.x Pratt, 1990, Consensus meeting agrees distribution of 5-HT3 receptors in mammalian hindbrain, Trends. Pharmac. Sci., 11, 135, 10.1016/0165-6147(90)90058-G Pritchett, 1988, Structure and functional expression of cloned rat serotonin 5-HT2 receptor, EMBO J., 7, 4135, 10.1002/j.1460-2075.1988.tb03308.x Quadid, 1992, Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors, Molec. Pharmac., 41, 346 Raiteri, 1986, Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum, J. Pharmac. Exp. Ther., 237, 644 Richardson, 1985, Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs, Nature, Lond., 316, 126, 10.1038/316126a0 Rittenhouse, 1990, Serotonin receptor subtypes mediating neuroendocrine responses to DOI, Pharmacologist, 32, 185 Ruat, 1993, A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation, Biochem. Biophys. Res. Comm., 193, 268, 10.1006/bbrc.1993.1619 Ruat, 1993, Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation, 90, 8547 Salzman, 1991, Cloning of the human 5-HT2 and 5-HT1C receptor subtypes, Biochem. Biophys. Res. Commun., 181, 1469, 10.1016/0006-291X(91)92105-S Schoeffter, 1990, 5-Hydroxytryptamine (5-HT) induced endothelium-dependent relaxation of pig cor-onary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype, J. Pharmac. Exp. Ther., 252, 387 Sharpley, 1990, Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans, Psychopharmacology, 101, 568, 10.1007/BF02244239 Shen, 1993, Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype, J. Biol. Chem., 268, 18200, 10.1016/S0021-9258(17)46830-X Sijbesma, 1991, 8-OH-DPAT increases the activity of adenylate cyclase in the hippocampus of freely-moving rats, Neuropharmacology, 30, 967, 10.1016/0028-3908(91)90110-W Sumner, 1989, Further characterisation of the 5-HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava, Br. J. Pharmac., 97, 292, 10.1111/j.1476-5381.1989.tb11953.x Sumner, 1992, Studies on the mechanism of 5-HT1 receptor-induced smooth muscle contraction in dog saphenous vein, Br. J. Pharmac., 105, 603, 10.1111/j.1476-5381.1992.tb09026.x Tarn, 1992, Investigation of the 5-HT receptor type involved in inhibition of spontaneous activity of human colonie circular muscle, Br. J. Pharmac., 106, 25P Trevethick, 1984, 5-Hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro, Life Sci., 35, 477, 10.1016/0024-3205(84)90240-6 Tsou, 1994, Cloning and expression of a 5-hydroxytryptamine7 receptor positively coupled to adenylyl cyclase, J. Neurochem., 10.1046/j.1471-4159.1994.63020456.x Tsutsumi, 1990, 5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1C receptor, J. Pharmac. Exp. Ther., 254, 253 Turconi, 1991, Azabicycloalkyl benzimidazolones: interaction with serotonergic 5-HT3 and 5-HT4 receptors and potential therapeutic implications, Drugs Future, 16, 1011, 10.1358/dof.1991.016.11.167591 Van Sande, 1993, The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells, Eur. J. Pharmac. Molec. Pharmac., 247, 177, 10.1016/0922-4106(93)90075-K Vergé, 1985, Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites, but not terminals are of the 5-HT1A subtype, Eur. J. Pharmac., 113, 463, 10.1016/0014-2999(85)90099-8 Vergé, 1986, Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats, J. Neurosci., 6, 3473, 10.1523/JNEUROSCI.06-12-03474.1986 Waeber, 1988, Localisation by autoradiography of neuronal 5-HT3 receptors in mouse CNS, Eur. J. Pharmac., 151, 351, 10.1016/0014-2999(88)90825-4 Waeber, 1989, 5-HT3 receptors in the human brain: Autoradiographic visualisation, Neuroscience, 31, 393, 10.1016/0306-4522(89)90382-5 Waeber, 1990, The serotonin 5-HT1D receptor: a progress review, Neurochem. Res., 15, 567, 10.1007/BF00973745 Wainscott, 1993, Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor, Molec. Pharmac., 43, 419 Witz, 1990, Cloning and characterisation of a Drosophila serotonin receptor that activates adenylate cyclase, 87, 8940 Yang, 1991, Human 5-HT2 receptor encoded by a multiple intron-exon containing gene, Soc. Neurosci. Abstr., 17, 405 Yu, 1991, The mouse 5-HT1C receptor contains eight hydro-phobic domains and is X-linked, Molec. Brain Res., 11, 143, 10.1016/0169-328X(91)90116-F Zgombick, 1991, Expression and pharmacological characterisation of a canine 5-hydroxytryptamine1D receptor sub-type, Molec. Pharmac., 40, 1036