pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil

Hanjani, 2022, Emerging role of exosomes as biomarkers in cancer treatment and diagnosis, Crit. Rev. Oncol.-Hematol., 169, 10.1016/j.critrevonc.2021.103565 Matthews, 2022, Cell cycle control in cancer, Nat. Rev. Mol. Cell Biol., 23, 74, 10.1038/s41580-021-00404-3 Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, Ca - Cancer J. Clin., 71, 209, 10.3322/caac.21660 Pourmadadi, 2022, Properties and applications of graphene and its derivatives in biosensors for cancer detection: a comprehensive review, Biosensors, 12, 269, 10.3390/bios12050269 Aghajanzadeh, 2022, Synergic antitumor effect of photodynamic therapy and chemotherapy mediated by nano drug delivery systems, Pharmaceutics, 14, 322, 10.3390/pharmaceutics14020322 Li, 2021, pH-Sensitive nanogels for drug delivery in cancer therapy, Biomater. Sci., 9, 574, 10.1039/D0BM01729A Kumar, 2022, Bioinspired quantum dots for cancer therapy: a mini-review, Mater. Lett., 10.1016/j.matlet.2022.131742 Mahdi Eshaghi, 2022, Novel carboxymethyl cellulose-based hydrogel with core–shell Fe3O4@ SiO2 nanoparticles for quercetin delivery, Materials, 15, 8711, 10.3390/ma15248711 Fattahi Bafghi, 2021, A novel delivery of curcumin by the efficient nanoliposomal approach against Leishmania major, Prep. Biochem. Biotechnol., 51, 990, 10.1080/10826068.2021.1885045 Azeem, 2022, An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review, Polym. Bull., 1 Hatahet, 2018, Liposomes, lipid nanocapsules and smartCrystals®: a comparative study for an effective quercetin delivery to the skin, Int. J. Pharm., 542, 176, 10.1016/j.ijpharm.2018.03.019 Samadi, 2021, Ameliorating quercetin constraints in cancer therapy with pH-responsive agarose-polyvinylpyrrolidone-hydroxyapatite nanocomposite encapsulated in double nanoemulsion, Int. J. Biol. Macromol., 182, 11, 10.1016/j.ijbiomac.2021.03.146 Pourmadadi, 2022, The synthesis and characterization of double nanoemulsion for targeted Co-Delivery of 5-fluorouracil and curcumin using pH-sensitive agarose/chitosan nanocarrier, J. Drug Deliv. Sci. Technol., 70 Kulshrestha, 2022, Magnetoresponsive biocomposite hydrogels comprising gelatin and valine based magnetic ionic liquid surfactant as controlled release nanocarrier for drug delivery, Mater. Adv., 3, 484, 10.1039/D1MA00758K Samadian, 2021, A novel alginate-gelatin microcapsule to enhance bone differentiation of mesenchymal stem cells, Int. J. Polym. Mater. Polym. Biomater., 1 Barichello, 1999, Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method, Drug Dev. Ind. Pharm., 25, 471, 10.1081/DDC-100102197 Battogtokh, 2022, Gelatin coating for the improvement of stability and cell uptake of hydrophobic drug-containing liposomes, Molecules, 27, 1041, 10.3390/molecules27031041 Yaghoubi, 2022, A functionalized graphene oxide with improved cytocompatibility for stimuli-responsive co-delivery of curcumin and doxorubicin in cancer treatment, Sci. Rep., 12, 1, 10.1038/s41598-022-05793-9 Mostafavi, 2022, Synthesis and characterization of gelatin-functionalized reduced graphene oxide for drug delivery application, Pathobiol. Res., 23, 75 Ghawanmeh, 2019, Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery, Nano Res., 12, 973, 10.1007/s12274-019-2300-4 Pourmadadi, 2021, Detection of microorganisms using graphene-based nanobiosensors, Food Technol. Biotechnol., 59, 496, 10.17113/ftb.59.04.21.7223 Gomaa, 2013, In vitro antioxidant, antimicrobial, and antitumor activities of bitter almond and sweet apricot (Prunus armeniaca L.) kernels, Food Sci. Biotechnol., 22, 455, 10.1007/s10068-013-0101-1 Moradi, 2017, A systematic review of phytochemical and phytotherapeutic characteristics of bitter almond, Int. J. Pharm. Phytopharmacol. Res., 7, 1 Kalajahi, 2022, Inhibition performances of graphene oxide/silver nanostructure for the microbial corrosion: molecular dynamic simulation study, Environ. Sci. Pollut. Control Ser., 1 Pourmadadi, 2020, An electrochemical sandwich immunosensor of vascular endothelial growth factor based on reduced graphene oxide/gold nanoparticle composites, Microchem. J., 159, 10.1016/j.microc.2020.105476 Sabzini, 2023, Development of chitosan/halloysite/graphitic-carbon nitride nanovehicle for targeted delivery of quercetin to enhance its limitation in cancer therapy: an in vitro cytotoxicity against MCF-7 cells, Int. J. Biol. Macromol., 226, 159, 10.1016/j.ijbiomac.2022.11.189 Fadlelmoula, 2022, Fourier Transform infrared (FTIR) spectroscopy to analyse human blood over the last 20 Years: a review towards lab-on-a-chip devices, Micromachines, 13, 187, 10.3390/mi13020187 Ali, 2022, X-ray diffraction techniques for mineral characterization: a review for engineers of the fundamentals, applications, and research directions, Minerals, 12, 205, 10.3390/min12020205 Aytac, 2016, Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility, Food Chem., 197, 864, 10.1016/j.foodchem.2015.11.051 Cagliari, 2011, Sugarcane Hsp101 is a hexameric chaperone that binds nucleotides, Int. J. Biol. Macromol., 49, 1022, 10.1016/j.ijbiomac.2011.08.027 Kumar, 2014, Quercetin conjugated superparamagnetic magnetite nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy applications, J. Colloid Interface Sci., 436, 234, 10.1016/j.jcis.2014.08.064 Zhang, 2011, Synthesis of monodisperse silver nanoparticles for ink-jet printed flexible electronics, Nanotechnology, 22, 10.1088/0957-4484/22/42/425601 Aayanifard, 2021, Ultra pH‐sensitive detection of total and free prostate‐specific antigen using electrochemical aptasensor based on reduced graphene oxide/gold nanoparticles emphasis on TiO2/carbon quantum dots as a redox probe, Eng. Life Sci., 21, 739, 10.1002/elsc.202000118 Bashir, 2021, CuxNi1-xO nanostructures and their nanocomposites with reduced graphene oxide: synthesis, characterization, and photocatalytic applications, Ceram. Int., 47, 3603, 10.1016/j.ceramint.2020.09.209 Grumezescu, 2019 Honary, 2013, Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 1), Trop. J. Pharmaceut. Res., 12, 255 Unger, 2007, Branched polyesters based on poly [vinyl-3-(dialkylamino) alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly (d, l-lactide-co-glycolide): effects of polymer structure on cytotoxicity, Biomaterials, 28, 1610, 10.1016/j.biomaterials.2006.12.002 Prabha, 2016, Preparation and characterization of chitosan—polyethylene glycol‐polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study, J. Biomed. Mater. Res. B Appl. Biomater., 104, 808, 10.1002/jbm.b.33637 Quagliariello, 2017, Hyaluronic acid nanohydrogel loaded with quercetin alone or in combination to a macrolide derivative of rapamycin RAD001 (Everolimus) as a new treatment for hormone‐responsive human breast cancer, J. Cell. Physiol., 232, 2063, 10.1002/jcp.25587 Liu, 2014, Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers, Colloids Surf. B Biointerfaces, 115, 125, 10.1016/j.colsurfb.2013.11.029 Borges, 2017, Mechanical ventilation weaning protocol improves medical adherence and results, J. Crit. Care, 41, 296, 10.1016/j.jcrc.2017.07.014 Kumar, 2016, Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: biochemical, pharmacokinetic and biodistribution evidences, Int. J. Pharm., 515, 307, 10.1016/j.ijpharm.2016.10.024 de Oliveira Pedro, 2018, Synergistic effect of quercetin and pH-responsive DEAE-chitosan carriers as drug delivery system for breast cancer treatment, Int. J. Biol. Macromol., 106, 579, 10.1016/j.ijbiomac.2017.08.056 Tiwari, 2019, Functionalized graphene oxide as a nanocarrier for dual drug delivery applications: the synergistic effect of quercetin and gefitinib against ovarian cancer cells, Colloids Surf. B Biointerfaces, 178, 452, 10.1016/j.colsurfb.2019.03.037 Selvaraj, 2021, Facile synthesis and characterization of quercetin-loaded alginate nanoparticles for enhanced in vitro anticancer effect against human leukemic cancer U937 cells, J. Cluster Sci., 32, 1507, 10.1007/s10876-020-01913-5 Halevas, 2020, Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity, J. Inorg. Biochem., 213, 10.1016/j.jinorgbio.2020.111271 Patel, 2020, Mycophenolate co-administration with quercetin via lipid-polymer hybrid nanoparticles for enhanced breast cancer management, Nanomed. Nanotechnol. Biol. Med., 24, 10.1016/j.nano.2019.102147 Imran, 2020, Topical nanostructured lipid carrier gel of quercetin and resveratrol: formulation, optimization, in vitro and ex vivo study for the treatment of skin cancer, Int. J. Pharm., 587, 10.1016/j.ijpharm.2020.119705 Ahmadi, 2021, Ultra pH-sensitive nanocarrier based on Fe2O3/chitosan/montmorillonite for quercetin delivery, Int. J. Biol. Macromol., 191, 738, 10.1016/j.ijbiomac.2021.09.023 Nematollahi, 2021, Synthesis and characterization of chitosan/polyvinylpyrrolidone coated nanoporous γ-Alumina as a pH-sensitive carrier for controlled release of quercetin, Int. J. Biol. Macromol., 183, 600, 10.1016/j.ijbiomac.2021.04.160 Siepmann, 2012, Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Adv. Drug Deliv. Rev., 64, 163, 10.1016/j.addr.2012.09.028 Zhao, 2019, A pH-sensitive microemulsion-filled gellan gum hydrogel encapsulated apigenin: characterization and in vitro release kinetics, Colloids Surf. B Biointerfaces, 178, 245, 10.1016/j.colsurfb.2019.03.015 Gurunathan, 2019, Evaluation of graphene oxide induced cellular toxicity and transcriptome analysis in human embryonic kidney cells, Nanomaterials, 9, 969, 10.3390/nano9070969 Vercellino, 2022, The assembly, regulation and function of the mitochondrial respiratory chain, Nat. Rev. Mol. Cell Biol., 23, 141, 10.1038/s41580-021-00415-0 Esmaeili, 2020, Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms, Sci. Rep., 10, 1, 10.1038/s41598-020-75090-w Huang, 2021, Near-infrared light enhanced starvation therapy to effectively promote cell apoptosis and inhibit migration, Mater. Adv., 2, 3981, 10.1039/D1MA00148E Gong, 2022, Fluorescent COFs with a highly conjugated structure for combined starvation and gas therapy, ACS Appl. Mater. Interfaces, 14, 46201, 10.1021/acsami.2c11423 Matiyani, 2022, Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells, RSC Adv., 12, 2574, 10.1039/D1RA05382E Mousavi, 2019, Applications of graphene oxide in case of nanomedicines and nanocarriers for biomolecules: review study, Drug Metab. Rev., 51, 12, 10.1080/03602532.2018.1522328 Caro, 2022, Nanomaterials loaded with Quercetin as an advanced tool for cancer treatment, J. Drug Deliv. Sci. Technol., 10.1016/j.jddst.2022.103938 Safari, 2022, Magnetically targeted delivery of Quercetin-loaded Ca1–xMnxFe2O4 nanocarriers: synthesis, characterization and in vitro study on HEK 293-T and MCF-7 cell lines, Appl. Phys. A, 128, 1, 10.1007/s00339-022-05612-y Sharma, 2020, Functionalized graphene oxide for chemotherapeutic drug delivery and cancer treatment: a promising material in nanomedicine, Int. J. Mol. Sci., 21, 6280, 10.3390/ijms21176280