Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans

American Journal of Sports Medicine - Tập 43 Số 10 - Trang 2522-2527 - 2015
Ferenc Tóth1, Mikko J. Nissi2,3,4,5, Jutta Ellermann3, Luning Wang3, Kevin G. Shea6,7, John D. Polousky8, Cathy S. Carlson1
1Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA
2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
3Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA
4Department of Radiology, Institute of Diagnostics, University of Oulu, Oulu, Finland
5Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
6Department of Orthopedics, University of Utah, Salt Lake City, Utah, USA
7St Luke's Health System, Boise, Idaho, USA
8The Rocky Mountain Hospital for Children, Denver, Colorado, USA

Tóm tắt

Background: Understanding the pathogenesis of osteochondrosis/osteochondritis dissecans and other developmental orthopaedic diseases that are thought to occur secondary to defects in vascular supply to growth/epiphyseal cartilage has been hampered by the inability to image the vasculature in this tissue. This is particularly true in human beings due to limitations of current imaging techniques and the lack of availability of appropriate cadaveric samples for histological studies. Hypothesis: Susceptibility-weighted imaging, an MRI sequence, allows identification of characteristic differences in the vascular architecture in species that are affected by osteochondrosis/osteochondritis dissecans on the femoral condyle (humans and pigs) versus a species that is free of the disease (goat). Study Design: Controlled laboratory study. Materials: Distal femora from cadavers of juvenile humans (n = 5), pigs (n = 3), and goats (n = 3) were scanned in a 9.4-T MRI scanner using susceptibility-weighted imaging. Three-dimensional reconstructions were created, and minimum intensity projections were calculated in 3 planes to enhance visualization of the vascular architecture. Results: Susceptibility-weighted imaging allowed clear visualization of the epiphyseal vasculature in all species. Vascular architecture, with vessels primarily arising from the perichondrium, was similar in humans and pigs, which are predisposed to osteochondrosis/osteochondritis dissecans, and was starkly different from that present in goats, a species in which there are no reports of osteochondrosis/osteochondritis dissecans. Furthermore, vessels in the distal femoral predilection site disappeared with age in humans in a pattern similar to that reported previously in pigs. Conclusion: Nearly identical vascular architecture at the shared primary predilection site of osteochondrosis/osteochondritis dissecans in the femoral condyles in human beings and pigs suggests that vascular failure, which is known to be central to the pathogenesis of this disease in pigs, may also play a role in humans. Clinical Relevance: This assumption of a shared pathogenesis is supported by the pattern of disappearance of vessels with age at the primary predilection site of osteochondritis dissecans in humans, which is essentially identical to that which has been reported in pigs. Susceptibility-weighted imaging will likely help further elucidate this potential relationship in the future.

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Tài liệu tham khảo

10.5435/00124635-199507000-00006

10.1002/jor.1100090303

10.5435/00124635-200602000-00004

10.1007/s11999-012-2290-y

Haines RW, 1933, J Anat, 68, 45

10.1007/s00330-011-2058-x

10.2214/ajr.182.2.1820353

10.1016/j.matbio.2014.04.001

10.1016/j.tvjl.2013.03.035

10.2746/042516408X297453

10.1016/j.joca.2013.08.011

10.1371/journal.pone.0132167

10.1002/mrm.24863

10.1016/j.joca.2013.02.005

10.1002/jor.20375

10.2746/042516408X300269

10.2746/042516407X239836

10.1177/0300985811398250

10.1016/j.joca.2014.11.009

10.1002/jor.22449

Visco DM, 1990, J Anat, 171, 25

10.1002/ar.1091730107

10.1016/j.orthres.2004.03.006

10.1354/vp.44-4-429

10.1016/j.bone.2003.07.011

10.1016/j.bone.2004.08.016

10.1111/j.1439-0442.2004.00621.x

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Thông tin xuất bản

American Journal of Sports Medicine

Tập 43 Số 10

2522-2527

Thông tin tác giả