Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

Lu, 2013, Bioengineered skin substitutes: key elements and novel design for biomedical applications, Int Wound J, 10, 365, 10.1111/j.1742-481X.2012.01105.x Papanas, 2012, Advances in the topical treatment of diabetic foot ulcers, Curr Diabetes Rev, 8, 209, 10.2174/157339912800563963 You, 2012, Treatment of diabetic foot ulcers using cultured allogeneic keratinocytes–a pilot study, Wound Repair Regen, 20, 491 Marston, 2003, Dermagraft Diabetic Foot Ulcer Study G. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial, Diabetes Care, 26, 1701, 10.2337/diacare.26.6.1701 Warriner, 2011, Human fibroblast-derived dermal substitute: results from a treatment investigational device exemption (TIDE) study in diabetic foot ulcers, Adv Skin Wound Care, 24, 306, 10.1097/01.ASW.0000399647.80210.61 Uccioli, 2011, Two-step autologous grafting using HYAFF scaffolds in treating difficult diabetic foot ulcers: results of a multicenter, randomized controlled clinical trial with long-term follow-up, Int J Low Extrem Wounds, 10, 80, 10.1177/1534734611409371 Steinberg, 2010, Confirmatory data from EU study supports Apligraf for the treatment of neuropathic diabetic foot ulcers, J Am Podiatr Med Assoc, 100, 73, 10.7547/1000073 Kim, 2010, Effect of human bone marrow stromal cell allograft on proliferation and collagen synthesis of diabetic fibroblasts in vitro, J Plast Reconstr Aesthet Surg, 63, 1030, 10.1016/j.bjps.2009.04.006 Lee, 2007, Effect of human bone marrow stromal cells and dermal fibroblasts on collagen synthesis and epithelization, Ann Plast Surg, 59, 713, 10.1097/SAP.0b013e318036aadf Han, 2006, The effect of human bone marrow stromal cells and dermal fibroblasts on angiogenesis, Plast Reconstr Surg, 117, 829, 10.1097/01.prs.0000201458.80364.31 Han, 2005, Potential of human bone marrow stromal cells to accelerate wound healing in vitro, Ann Plast Surg, 55, 414, 10.1097/01.sap.0000178809.01289.10 Zebardast, 2010, Human umbilical cord perivascular cells (HUCPVC): A mesenchymal cell source for dermal wound healing, Organogenesis, 6, 197, 10.4161/org.6.4.12393 Oh, 2008, Immunological properties of umbilical cord blood-derived mesenchymal stromal cells, Cell Immunol, 251, 116, 10.1016/j.cellimm.2008.04.003 Malgieri, 2010, Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art, Int J Clin Exp Med, 3, 248 Kim, 2010, Application of human umbilical cord blood-derived mesenchymal stem cells in disease models, World J Stem Cells, 2, 34, 10.4252/wjsc.v2.i2.34 Tark, 2010, Effects of human cord blood mesenchymal stem cells on cutaneous wound healing in leprdb mice, Ann Plast Surg, 65, 565, 10.1097/SAP.0b013e3181d9aae2 Liao, 2014, Human Cord Blood Derived Unrestricted Somatic Stem Cells Promote Wound Healing and Have Therapeutic Potential for Patients With Recessive Dystrophic Epidermolysis Bullosa, Cell Transplant, 23, 303, 10.3727/096368913X663569 Chotinantakul, 2013, Enhancement of wound closure in diabetic mice by ex vivo expanded cord blood CD34+ cells, Cell Mol Biol Lett, 18, 263, 10.2478/s11658-013-0089-9 Shohara, 2012, Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms, Cytotherapy, 14, 1171, 10.3109/14653249.2012.706705 Elsharawy, 2012, Human CD34+ stem cells promote healing of diabetic foot ulcers in rats, Interact Cardiovasc Thorac Surg, 14, 288, 10.1093/icvts/ivr068 Cabrera, 2012, The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells, Ann N Y Acad Sci, 1270, 93, 10.1111/j.1749-6632.2012.06727.x Reddi, 2011, The use of human umbilical cord blood for wound healing, burns, and brain injury in combat zones, Mil Med, 176, 361, 10.7205/MILMED-D-10-00229 Luo, 2010, Promotion of cutaneous wound healing by local application of mesenchymal stem cells derived from human umbilical cord blood, Wound Repair Regen, 18, 506, 10.1111/j.1524-475X.2010.00616.x Branski, 2009, A review of gene and stem cell therapy in cutaneous wound healing, Burns, 35, 171, 10.1016/j.burns.2008.03.009 Yang, 2004, Mesenchymal stem/progenitor cells developed in cultures from UC blood, Cytotherapy, 6, 476, 10.1080/14653240410005041 Edmonds, 2009, Apligraf in the treatment of neuropathic diabetic foot ulcers, Int J Low Extrem Wounds, 8, 11, 10.1177/1534734609331597 Han, 2004, Clinical application of fresh fibroblast allografts for the treatment of diabetic foot ulcers: a pilot study, Plast Reconstr Surg, 114, 1783, 10.1097/01.PRS.0000142415.57470.DF Han, 2009, Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers, Dermatol Surg, 35, 1342, 10.1111/j.1524-4725.2009.01239.x Zhao, 2013, Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats, Int J Biol Sci, 10, 80, 10.7150/ijbs.7237 Li, 2013, Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies, Curr Pharm Des, 19, 4893, 10.2174/13816128113199990326 Lerman, 2003, Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia, Am J Pathol, 162, 303, 10.1016/S0002-9440(10)63821-7 You, 2014, Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers, J Wound Care, 23 Lee, 2014, Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo, Biochem Biophys Res Commun, 446, 983, 10.1016/j.bbrc.2014.03.051