The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

Anis, 1983, The dissociative anesthetics, ketamine and phenclyclidine, selectively reduce excitation of central mammalian neurons by N-methyl-aspartate, Br. J. Pharmacol., 71, 565, 10.1111/j.1476-5381.1983.tb11031.x Barrell, 1975, The perception of first and second pain as a function of psychological set, Percept. Psychophys., 17, 163, 10.3758/BF03203881 Bem, 1992, Dextromethorphan: an overview of safety issues, Drug Safety, 7, 190, 10.2165/00002018-199207030-00004 Bennett, 1991, Evidence from animal models on the pathogenesis of painful peripheral neruopathy, and its relevance for pharmacotherapy, 365 Byas-Smith, 1993, Intravenous ketamine and alfentanyl in patients with chronic causalgic pain and allodynia, 454 Campbell, 1983, Latency to detection of first pain, Brain Res., 266, 203, 10.1016/0006-8993(83)90650-9 Choi, 1987, Dextrorphan and levarphenol selectively block N-methyl-d-aspartate receptor-mediated neurotoxicity on cortical neurons, J. Pharmacol. Exp. Ther., 242, 713 Davies, 1987, Evidence for involvement of N-metyl-d-aspartate receptors in ‘windup’ of class 2 neurons in the dorsal horn of the rat, Brain Res., 424, 402, 10.1016/0006-8993(87)91487-9 Dickenson, 1987, Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons follwing C fiber stimulation, Neuropharmacology, 26, 1235, 10.1016/0028-3908(87)90275-9 Dickenson, 1990, Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurons in the rat, Brain Res., 506, 31, 10.1016/0006-8993(90)91195-M Dickenson, 1991, Dextromethorphan and Levorphanol on dorsal horn nociceptive neurons in the rat, Neuropharmacology, 30, 1303, 10.1016/0028-3908(91)90027-9 Dubner, 1991, Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury, Vol. 5, 263 Dubner, 1987, Idiopathic trigeminal neuralgia: sensory features and pain mechanisms, Pain, 31, 23, 10.1016/0304-3959(87)90003-0 Ferkany, 1988, Dextromethorphan inhibits NMDA-induced convulsions, Eur. J. Pharmacol., 151, 151, 10.1016/0014-2999(88)90707-8 George, 1988, Dextromethorphan reduces neocortical ischemie damage in vivo, Brain Res., 440, 375, 10.1016/0006-8993(88)91011-6 Gracely, 1992, Painful neuropathy: altered central processing maintained dynamically by peripheral input, Pain, 51, 175, 10.1016/0304-3959(92)90259-E Hylden, 1989, Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms, Pain, 37, 243, 10.1016/0304-3959(89)90135-8 Kelstein, 1990, Evidence that substance P selectively modulates C-fiber evoked discharges of dorsal horn nociceptive neurons, Brain Res., 26, 291, 10.1016/0006-8993(90)91234-8 Klepstad, 1990, Evidence of a role for NMDA receptors in pain perception, Eur. J. Pharmacol., 187, 513, 10.1016/0014-2999(90)90379-K Mao, J., Price, D. D. and Mayer, D. J., Mechanisms of hyperalgesia and opiate tolerance: a current view of their possible interactions, submitted. Mendell, 1966, Physiological properties of unmyelinated fiber projections to the spinal cord, Exp. Neurol., 16, 971, 10.1016/0014-4886(66)90068-9 Noordenbos, 1959 Palecek, 1992, Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy, J. Neurophysiol., 67, 1562, 10.1152/jn.1992.67.6.1562 Park, 1993, Effects of intravenous ketamine and alfentanil on hyperalgesia induced by intradermal capsaicin, 454 Price, 1972, Characteristics of second pain and flexion reflexes indicative of prolonged central summation, Exp. Neurol., 37, 371, 10.1016/0014-4886(72)90081-7 Price, 1988 Price, 1988, Effects of heterotopic conditioning stimuli on first and second pain: a psychophysical evaluation in humans, Pain, 34, 245, 10.1016/0304-3959(88)90119-4 Price, 1971, Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli, Exp. Neurol., 33, 291, 10.1016/0014-4886(71)90022-7 Price, 1977, Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses, Pain, 3, 57, 10.1016/0304-3959(77)90035-5 Price, 1978, Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensation, J. Neurophysiol., 41, 933, 10.1152/jn.1978.41.4.933 Price, 1979, Functional relationships between neurons of marginal and substantia gelatinosa layers of primate dorsal horn, J. Neurophysiol., 41, 933, 10.1152/jn.1978.41.4.933 Price, 1985, A psychophysical analysis of morphine analgesia, Pain, 22, 261, 10.1016/0304-3959(85)90026-0 Price, 1989, Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block, Pain, 36, 209, 10.1016/0304-3959(89)90086-9 Price, 1992, Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy, Pain, 49, 163, 10.1016/0304-3959(92)90139-3 Price, 1992, The psychophysical attributes of heat-induced pain and their relationships to neural mechanisms, J. Cogni. Neurosci., 4, 1, 10.1162/jocn.1992.4.1.1 Price, 1994, Central neural mechanisms of normal and abnormal pain states, 61 Price, 1994, A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales, Pain, 56, 217, 10.1016/0304-3959(94)90097-3 Ren, 1985, The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation, Pain, 50, 331, 10.1016/0304-3959(92)90039-E Thompson, 1990, Primary afferent-evoked prolonged potentials in the spinal cord and their central summation: role of the NMDA receptor Urban, 1984, Slow excitatory transmission in rat dorsal horn: possible mediation by peptides, Brain Res., 290, 336, 10.1016/0006-8993(84)90952-1 Wagman, 1969, Responses of dorsal horn cells of M. mulatta to cutaneous and sural nerve A and C fiber stimuli, J. Neurophysiol., 32, 803, 10.1152/jn.1969.32.6.803 Wilcox, 1991, Excitatory neurotransmitters and pain, 97 Willis, 1985 Woolf, 1991, The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states, Pain, 44, 293, 10.1016/0304-3959(91)90100-C