Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

Radiotherapy and Oncology - Tập 92 Số 3 - Trang 411-416 - 2009
Kasper M.A. Rouschop1, Chantal H.M.A. Ramaekers1,2,3, Marco B.E. Schaaf1, Tom G. Keulers1, Kim G.M. Savelkouls1, Philippe Lambin1, Marianne Koritzinsky1,2,3, Bradly G. Wouters1,2,3
1Maastricht Radiation Oncology (MaastRo) Lab, Grow-School for Oncology and Developmental Biology, University of Maastricht, The Netherlands
2Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada
3Selective Therapeutics Program, Ontario Institute for Cancer Research, Toronto, Canada

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Fyles, 2006, Long-term performance of intestinal fluid pressure and hypoxia as prognostic factors in cervix cancer, Radiother Oncol, 80, 132, 10.1016/j.radonc.2006.07.014

Nordsmark, 2005, Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study, Radiother Oncol, 77, 18, 10.1016/j.radonc.2005.06.038

Nordsmark, 2006, The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study, Radiother Oncol, 80, 123, 10.1016/j.radonc.2006.07.010

Durand, 2001, Clinical relevance of intermittent tumour blood flow, Acta Oncol, 40, 929, 10.1080/02841860152708206

Brown, 1979, Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation, Br J Radiol, 52, 650, 10.1259/0007-1285-52-620-650

Dewhirst, 2007, Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting, Cancer Res, 67, 854, 10.1158/0008-5472.CAN-06-4744

Dewhirst, 1998, Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats, Int J Radiat Oncol Biol Phys, 42, 723, 10.1016/S0360-3016(98)00304-6

Chaplin, 1987, Intermittent blood flow in a murine tumor: radiobiological effects, Cancer Res, 47, 597

Dewhirst, 2008, Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response, Nat Rev Cancer, 8, 425, 10.1038/nrc2397

Toffoli, 2008, Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours, FEBS J, 275, 2991, 10.1111/j.1742-4658.2008.06454.x

Mizushima, 2005, The pleiotropic role of autophagy: from protein metabolism to bactericide, Cell Death Differ, 12, 1535, 10.1038/sj.cdd.4401728

Tanida, 2004, LC3 conjugation system in mammalian autophagy, Int J Biochem Cell Biol, 36, 2503, 10.1016/j.biocel.2004.05.009

Kuma, 2004, The role of autophagy during the early neonatal starvation period, Nature, 432, 1032, 10.1038/nature03029

Mizushima, 2002, Autophagosome formation in mammalian cells, Cell Struct Funct, 27, 421, 10.1247/csf.27.421

Klionsky, 2008, Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes, Autophagy, 4, 151, 10.4161/auto.5338

Boya, 2005, Inhibition of macroautophagy triggers apoptosis, Mol Cell Biol, 25, 1025, 10.1128/MCB.25.3.1025-1040.2005

Yamamoto, 1998, Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells, Cell Struct Funct, 23, 33, 10.1247/csf.23.33

Klionsky, 2000, Autophagy as a regulated pathway of cellular degradation, Science, 290, 1717, 10.1126/science.290.5497.1717

Tan, 2008, Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases, Hum Mol Genet, 17, 431, 10.1093/hmg/ddm320

Mukhopadhyay, 2007, Proteasome-independent functions of ubiquitin in endocytosis and signaling, Science, 315, 201, 10.1126/science.1127085

Zhang, 2008, Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia, J Biol Chem, 283, 10892, 10.1074/jbc.M800102200

Chiu, 2006, Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations, PLoS Genet, 2, e116, 10.1371/journal.pgen.0020116

Koritzinsky, 2007, Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia, Radiother Oncol, 83, 353, 10.1016/j.radonc.2007.04.031

Li, 2002, Reactive species mechanisms of cellular hypoxia-reoxygenation injury, Am J Physiol Cell Physiol, 282, C227, 10.1152/ajpcell.00112.2001

Wouters, 2004, Targeting hypoxia tolerance in cancer, Drug Resist Updat, 7, 25, 10.1016/j.drup.2003.12.004

Deffieu, 2009, Glutathione participates in the regulation of mitophagy in yeast, J Biol Chem, 284, 14828, 10.1074/jbc.M109.005181

Kim, 2008, A critical role of superoxide anion in selenite-induced mitophagic cell death, Autophagy, 4, 76, 10.4161/auto.5119

Lum, 2005, Autophagy in metazoans: cell survival in the land of plenty, Nat Rev Mol Cell Biol, 6, 439, 10.1038/nrm1660

Wouters, 2008, Hypoxia signalling through mTOR and the unfolded protein response in cancer, Nat Rev Cancer, 10.1038/nrc2501

Pursiheimo, 2009, Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62, Oncogene, 28, 334, 10.1038/onc.2008.392

Mathew, 2007, Role of autophagy in cancer, Nat Rev Cancer, 7, 961, 10.1038/nrc2254

Karantza-Wadsworth, 2007, Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis, Genes Dev, 21, 1621, 10.1101/gad.1565707

Mathew, 2007, Autophagy suppresses tumor progression by limiting chromosomal instability, Genes Dev, 21, 1367, 10.1101/gad.1545107