Preparation, characterization, and in vitro efficacy of O-carboxymethyl chitosan conjugate of melphalan

Anitha, 2011, Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells, Carbohydrate Polymers, 83, 452, 10.1016/j.carbpol.2010.08.008 Beyer, 1998, Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil, Journal of Medicinal Chemistry, 41, 2701, 10.1021/jm9704661 Bielawski, 2011, Cytotoxic activity of G3 PAMAM-NH2 dendrimer-chlorambucil conjugate in human breast cancer cells, Environmental Toxicology and Pharmacology, 32, 364, 10.1016/j.etap.2011.08.002 Bonifacino, 2009 Chau, 2004, Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX, Bioconjugate Chemistry, 15, 931, 10.1021/bc0499174 David, 1999, New injectable melphalan formulations utilizing (SBE)7m-β-CD or HP-β-CD, International Journal of Pharmaceutics, 189, 227, 10.1016/S0378-5173(99)00255-0 Ding, 2012, PEG prodrug of gambogic acid: Amino acid and dipeptide spacer effects, Polymer, 53, 1694, 10.1016/j.polymer.2012.02.022 Duncan, 1991, Macromolecular prodrugs for use in targeted cancer chemotherapy: Melphalan covalently coupled to N-(2-hydroxypropyl) methacrylamide copolymers, Journal of Controlled Release, 16, 121, 10.1016/0168-3659(91)90036-D Fu, 2011, Effects of carboxymethyl chitosan on the blood system of rats, Biochemical and Biophysical Research Communications, 408, 110, 10.1016/j.bbrc.2011.03.130 Gong, 2012, Preparation characterization and in vitro release study of a glutathione-dependent polymeric prodrug cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan, International Journal of Pharmaceutics, 43, 240, 10.1016/j.ijpharm.2012.06.043 Greenwald, 2001, PEG drugs: An overview, Journal of Controlled Release, 74, 159, 10.1016/S0168-3659(01)00331-5 Khandare, 2006, Polymer–drug conjugates: Progress in polymeric prodrugs, Progress in Polymer Science, 31, 359, 10.1016/j.progpolymsci.2005.09.004 Kratz, 1998, Albumin conjugates of the anticancer drug chlorambucil: Synthesis, characterization and in vitro efficacy, Archive der Pharmazie Pharmaceutical & Medicinal Chemistry, 331, 47, 10.1002/(SICI)1521-4184(199802)331:2<47::AID-ARDP47>3.0.CO;2-R Lee, 2009, In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration, Journal of Controlled Release, 140, 79, 10.1016/j.jconrel.2009.08.014 Mahato, 2011, Prodrugs for improving tumor targetability and efficiency, Advanced Drug Delivery Reviews, 63, 659, 10.1016/j.addr.2011.02.002 Mehvar, 2000, Kinetics of hydrolysis of dextran-methylprednisolone succinate, a macromolecular prodrug of methylprednisolone, in rat blood and liver lysosomes, Journal of Controlled Release, 68, 53, 10.1016/S0168-3659(00)00234-0 Miot-Noirault, 2011, Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents, Invest New Drugs, 29, 424, 10.1007/s10637-009-9371-0 Mitsunori, 2000, Determinants for the drug release from T-0128 camptothecin analogue-carboxymethyl dextran conjugate, Journal of Controlled Release, 69, 399, 10.1016/S0168-3659(00)00321-7 Mittal, 2004, Prolidase, a potential enzyme target for melanoma: Design of proline-containing dipeptide-like prodrugs, Molecular Pharmaceutics, 2, 37, 10.1021/mp049922p Morris, 1997, The synthesis of novel melphalan derivatives as potential antineoplastic agents, European Journal of Medicinal Chemistry, 32, 343, 10.1016/S0223-5234(97)89087-3 Peyrode, 2012, Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: In vitro and in vivo preclinical studies, Invest New Drugs, 30, 1782, 10.1007/s10637-011-9663-z Repnik, 2012, Lysosomes and lysosomal cathepsins in cell death, Biochimica et Biophysica Acta, 1824, 22, 10.1016/j.bbapap.2011.08.016 Sabaa, 2010, Synthesis, characterization and antimicrobial activity of poly (N-vinyl imidazole) grafted carboxymethyl chitosan, Carbohydrate Polymers, 79, 998, 10.1016/j.carbpol.2009.10.024 Sartania, 1999, Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative, European Journal of Pharmacology, 373, 241, 10.1016/S0014-2999(99)00248-4 Scutaru, 2011, Bivalent bendamustine and melphalan derivatives as anticancer agents, European Journal of Medicinal Chemistry, 46, 1604, 10.1016/j.ejmech.2011.02.008 Tsay, 1987, Phase I study of beta-alanyl-melphalan as a potent anticancer drug, Cancer Chemotherapy and Pharmacology, 19, 190, 10.1007/BF00252971 Tokura, 1994, Induction of drug specific antibody and the controlled release of drug by 6-O-carboxymethyl-chitin, Journal of Controlled Release, 28, 235, 10.1016/0168-3659(94)90170-8 Wang, 2011, Self-assembled nanoparticles of methotrexate conjugated O-carboxymethyl chitosan: Preparation, characterization and drug release behavior in vitro, Carbohydrate Polymers, 86, 1665, 10.1016/j.carbpol.2011.06.080 Yasunori, 1984, Antitumor agent poly (amino acid) conjugates as a drug carrier in cancer chemotherapy, Journal of Pharmacobio-dynamics, 7, 688, 10.1248/bpb1978.7.688 Zhao, 2010, Novel melphalan and chlorambucil derivatives of 2,2,6,6-tetramethyl-1-piperidinyloxy radicals: Synthesis, characterization, and biological evaluation in vitro, Chemical and Pharmaceutical Bulletin, 58, 332, 10.1248/cpb.58.332 Zheng, 2011, Synthesis, characterization and biological safety of O-carboxymethyl chitosan used to treat Sarcoma 180 tumor, Carbohydrate Polymer, 86, 231, 10.1016/j.carbpol.2011.04.038 Zheng, 2011, Preparation, characterization, and in vitro drug release behavior of 6-mercaptopurine-carboxymethyl chitosan, Carbohydrate Polymer, 83, 1952, 10.1016/j.carbpol.2010.10.069