A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

Keene, J. A. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155, 768–782 (1982).

Mitchison, N. A. & O'Malley, C. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur. J. Immunol. 17, 1579–1583 (1987).

Bennett, S. R., Carbone, F. R., Karamalis, F., Miller, J. F. & Heath, W. R. Induction of a CD8 cytotoxic T lymphocyte response by cross-priming requires cognate CD4 T cell help. J. Exp. Med. 186, 65–70 (1997).

Guerder, S. & Matzinger, P. Activation versus tolerance: a decision made by helper T cells. Cold Spring Harb. Symp. Quant. Biol. 54, 799 (1989).

Rees, M. A., Rosenberg, A. S., Munitz, T. I. & Singer, A. In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help. Proc. Natl Acad. Sci. USA 87, 2765–2769 (1990).

Guerder, S. & Matzinger, P. Afail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176, 553–564 (1992).

Simpson, E. & Gordon, R. D. Responsiveness to H-Y antigen: Ir gene complementation and target cell specificity. Immunol. Rev. 35, 59–75 (1977).

Gray, D. & Matzinger, P. Tcell memory is short-lived in the absence of antigen. J. Exp. Med. 174, 969–974 (1991).

Fuchs, E. J. & Matzinger, P. Bcells turn off virgin but not memory T cells. Science 258, 1156–1159 (1992).

Ridge, J. P., Fuchs, E. J. & Matzinger, P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells [see comments]. Science 271, 1723–1726 (1996).

Boog, C. J. et al. Abolition of specific immune response defect by immunization with dendritic cells. Nature 318, 59–62 (1985).

Saeland, S., Duvert, V., Moreau, I. & Banchereau, J. Human B cell precursors proliferate and express CD23 after CD40 ligation. J. Exp. Med. 178, 113–120 (1993).

Cella, M. et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747–752 (1996).

Yang, Y. & Wilson, J. M. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signalling through CD40. Science 273, 1862–1864 (1996).

Bendelac, A. et al. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15, 535–562 (1997).

Buller, R. M., Holmes, K. L., Hugin, A., Frederickson, T. N. & Morse III, H. C. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 328, 77–79 (1987).

Hou, S., Mo, X. Y., Hyland, L. & Doherty, P. C. Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J. Virol. 69, 1429–1434 (1995).

Tripp, R. A., Sarawar, S. R. & Doherty, P. C. Characteristics of the influenza virus-specific CD8 T cell responses in mice homozygous for disruption of the H-2IAb gene. J. Immunol. 155, 2955–2959 (1995).

Ahmed, R., Butler, L. D. & Bhatti, L. T4 T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T cell and antibody responses. J. Virol. 62, 2102–2106 (1988).

Yong, J. L. et al. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2, 239–248 (1995).

Wu, Y. & Liu, Y. Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses. Curr. Biol. 4, 499–505 (1994).

Paliard, X. et al. Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4 and CD8 T cell clones. J. Immunol. 141, 849–855 (1988).

Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991–1045 (1994).

Katona, I. M., Urban, J. F. J, Kang, S. S., Paul, W. E. & Finkelman, F. D. IL-4 requirements for the generation of secondary in vivo IgE responses. J. Immunol. 146, 4215–4221 (1991).

Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A. & Weiner, H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237–1240 (1994).

Stavnezer, J. Regulation of antibody production and class switching by TGF-beta. J. Immunol. 155, 1647–1651 (1995).

Liu, L., Rich, B. E., Inobe, J., Chen, W. & Weiner, H. L. Apotential pathway of Th2 development during the primary immune response: IL-10 pretreated dendritic cells prime naive CD4+ T cells to secrete IL-4. Adv. Exp. Med. Biol. 417, 375–381 (1997).

Wilbanks, G. A. & Streilein, J. W. Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-beta. Eur. J. Immunol. 22, 1031–1036 (1992).

Janeway, C. A. J Approaching the asymptote? Evolution and revolution in immunology. Cold. Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

Nonacs, R., Humborg, C., Tam, J. P. & Steinman, R. M. Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes. J. Exp. Med. 176, 519–529 (1997).