The mechanism of action of aspirin

Thrombosis Research - Tập 110 - Trang 255-258 - 2003
J.R Vane1, R.M Botting1
1The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK

Tài liệu tham khảo

Maclagan, 1876, The treatment of acute rheumatism by salicin, Lancet, i, 342, 10.1016/S0140-6736(02)46434-3 Dreser, 1899, Pharmacologisches über Aspirin (Acetylsalicyl-saüre), Pflugers Arch., 76, 306, 10.1007/BF01662127 Beaver, 1965, Mild analgesics: a review of their clinical pharmacology, Am. J. Med. Sci., 250, 577, 10.1097/00000441-196511000-00011 Guzman, 1964, Narcotic and non-narcotic analgesics which block visceral pain evoked by intra-arterial injections of bradykinin and other algesic agents, Arch. Int. Pharmacodyn., 149, 571 Lim, 1964, Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin-evoked visceral pain, Arch. Int. Pharmacodyn., 152, 25 Whitehouse, 1965, Some biochemical and pharmacological properties of anti-inflammatory drugs, Prog. Drug Res., 8, 321 Piper, 1969, Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs, Nature, 223, 29, 10.1038/223029a0 Vane, 1964, The use of isolated organs for detecting active substances in the circulating blood, Br. J. Pharmacol. Chemother., 23, 360, 10.1111/j.1476-5381.1964.tb01592.x Hamberg, 1975, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. U. S. A., 72, 2994, 10.1073/pnas.72.8.2994 Piper, 1969, The release of prostaglandins during anaphylaxis in guinea-pig isolated lungs, 15 Änggård, 1965, Biosynthesis of prostaglandins from arachidonic acid in guinea-pig lung, J. Biol. Chem., 240, 3518, 10.1016/S0021-9258(18)97174-7 Vane, 1971, Inhibition of prostaglandin synthesis as a mechanism of action for Aspirin-like drugs, Nat. New Biol., 231, 232, 10.1038/newbio231232a0 Smith, 1971, Aspirin selectively inhibits prostaglandin production in human platelets, Nature, 231, 235 Ferreira, 1971, Indomethacin and Aspirin abolish prostaglandin release from spleen, Nature, 231, 237 Collier, 1971, Effect of Aspirin on human seminal prostaglandins, Lancet, ii, 852, 10.1016/S0140-6736(71)90225-X Milton, 1970, A possible role for prostaglandin E1 as a modulator of temperature regulation in the central nervous system of the cat, J. Physiol., 207, 76 Di Rosa, 1971, Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine, J. Physiol., 104, 15 Flower, 1972, The effects of anti-inflammatory drugs on a cell-free prostaglandin synthetase system from dog spleen, Nature, 238, 104 Hemler, 1976, Purification of the cyclooxygenase that forms prostaglandins: demonstration of two forms of iron in the holoenzyme, J. Biol. Chem., 251, 5575, 10.1016/S0021-9258(17)33098-3 Smith, 1986, Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells, Annu. Rev. Physiol., 48, 251, 10.1146/annurev.ph.48.030186.001343 Roth, 1975, The mechanism of the effect of Aspirin on human platelets: 1. Acetylation of a particulate fraction protein, J. Clin. Invest., 56, 624, 10.1172/JCI108132 Smith, 1989, The eicosanoids and their biochemical mechanisms of action, Biochem. J., 259, 315, 10.1042/bj2590315 De Witt, 1990, The Aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases, J. Biol. Chem., 265, 5192, 10.1016/S0021-9258(19)34105-5 Raz, 1988, Regulation of fibroblast cyclooxygenase synthesis by interleukin-1, J. Biol. Chem., 263, 3022, 10.1016/S0021-9258(18)69170-7 Raz, 1989, Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases, Proc. Natl. Acad. Sci. U. S. A., 86, 1657, 10.1073/pnas.86.5.1657 Xie, 1991, Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing, Proc. Natl. Acad. Sci. U. S. A., 88, 2692, 10.1073/pnas.88.7.2692 Vane, 1998, Cyclooxygenases 1 and 2, Annu. Rev. Pharmacol. Toxicol., 38, 97, 10.1146/annurev.pharmtox.38.1.97 Silverstein, 2000, Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomised controlled trial. Celecoxib Long-term Arthritis Safety Study, J. Am. Med. Assoc., 284, 1247, 10.1001/jama.284.10.1247 Bombardier, 2000, Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis, N. Engl. J. Med., 343, 1520, 10.1056/NEJM200011233432103 Dequeker, 1998, Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the safety and efficacy large-scale evaluation of COX-inhibiting therapies (SELECT) trial in osteoarthritis, Br. J. Rheumatol., 37, 946, 10.1093/rheumatology/37.9.946 Fiorucci, 2003, Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study, Gastroenterology, 124, 600, 10.1053/gast.2003.50096 Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proc Natl Acad Sci U S A 99:13926–13931.