Hydroxamic acid polymers. II. Design of a polymeric chelating agent for iron

Wiley - Tập 14 Số 9 - Trang 2155-2165 - 1976
Anthony Winston1, Glenn R. McLaughlin1
1Department of Chemistry, West Virginia University, Morgantown, West Virginia, 26506

Tóm tắt

AbstractThe iron chelating ability of hydroxamic acid polymers was studied as a function of the atomic chain spacing separating neighboring hydroxamic acid units. Two polymers were prepared, one having the hydroxamic acid group separated by 11 atoms and the other by three atoms. The iron binding of these polymers was compared with the model compound desferrioxamine B (DFO) and with a previously prepared polymer having a nine‐atom spacing. Mole ratio plots indicated the following order of stability: DFO ≈ 11 atom > 9 atom > 3 atom. These results are in accordance with the picture derived from molecular models which shows that with a spacing of 11 atoms, three neighboring hydroxamic acids can fit the octahedral arrangement of the iron (III) complex without appreciable strain. Some strain is introduced when the spacing becomes only nine atoms, and with three atoms, complex formation between three neighboring groups becomes virtually impossible.

Từ khóa


Tài liệu tham khảo

10.1021/cr60106a002

Mathis F., Bull. Soc. Chim. France, 1953, D9

10.1007/BFb0119549

10.1351/pac197128040603

10.1002/hlca.19630460436

Waxman H. S., 1969, Progress in Hematology, 338

10.1080/10601327308060480

R. S.RamirezandJ. D.Andrade paper presented at the 167th Meeting of the American Chemical Society Los Angeles Calif. April 1974;

1974, Polym. Preprints, 15, 391

10.1002/pol.1975.170130906

10.1016/0032-3861(72)90084-5

10.1002/ange.19570690502

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Thông tin xuất bản

Wiley

Tập 14 Số 9

2155-2165

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