Endogenous growth factor stimulation of hemocyte proliferation induces resistance to <i>Schistosoma mansoni</i> challenge in the snail host

Emmanuel A. Pila1, Michelle A. Gordy1, Valerie K. Phillips1, Alèthe L. Kaboré1, Sydney P. Rudko1, Patrick C. Hanington1
1School of Public Health, University of Alberta, Edmonton, AB, Canada T6G2G7

Tóm tắt

Significance Snails serve as hosts for the larval development of many medically and agriculturally important parasitic flatworms, including schistosomes, blood flukes that collectively infect more than 260 million people globally. Here, we functionally characterize a granulin-like snail growth factor that drives the development of snail immune cells, thereby making a schistosome-susceptible snail resistant to infection. This study presents the functional characterization of an endogenous gastropod growth factor as well as demonstrated reversal of a susceptible snail phenotype toward resistance using a defined snail factor.

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