Seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens enhances sexual performance and improves male reproductive damages in ethanol-induced rats

Adler, 1996, Comparison of the duration of spermatogenesis between male rodents and humans, Mutat. Res., 352, 169, 10.1016/0027-5107(95)00223-5 Agmo, 1997, Male rat sexual behavior, Brain Res. Protoc., 1, 203, 10.1016/S1385-299X(96)00036-0 Ahmad, 2008, Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men, Fertil. Steril., 90, 627, 10.1016/j.fertnstert.2007.07.1314 Akbari, 2017, The protective effect of hydroalcoholic extract of Zingiber officinale Roscoe (ginger) on ethanol-induced reproductive toxicity in male rats, J. Evid. Based. Complementary. Altern. .Med., 22, 609, 10.1177/2156587216687696 Aronowski, 2003, Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience, Stroke, 34, 1246, 10.1161/01.STR.0000068170.80517.B3 Arun, 2016, Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats, Int. J. Reprod. Biomed., 14, 443, 10.29252/ijrm.14.7.2 Arun, 2018, Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress, J. Zhejiang Univ. - Sci. B, 19, 948, 10.1631/jzus.B1800362 Atli, 2017, Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms, Asian J. Androl., 19, 672, 10.4103/1008-682X.192637 Bendahmane, 2002, Assessment of acrosomal status in rat spermatozoa: studies on carbohydrate and non-carbohydrate agonists, Arch. Biochem. Biophys., 404, 38, 10.1016/S0003-9861(02)00278-3 Boyd, 2010, Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis, J. Neurochem., 112, 784, 10.1111/j.1471-4159.2009.06509.x Burawat, 2018, Effects of Leucaena leucocephala (Lamk.) shoot tips plus young leaf extract containing mimosine on reproductive system of male rats, J. Morphol., 36, 1062 Castaneda, 2020, Vibrational spectra and theoretical calculations of a natural pentacyclic triterpene alcohol isolated from Mucuna pruriens, Struct. Chem., 31, 599, 10.1007/s11224-019-01431-9 Chaichun, 2019, Mimosine increases the expressions of tyrosine phosphorylated protein in mouse seminal vesicles, J. Morphol., 37, 1463 Chaimontri, 2021, The effect of Dolichandrone serrulata (wall. ex DC.) Seem. flower extract containing antioxidant capacity and terpenoids on the male reproductive system, Andrologia, 53, 10.1111/and.13966 Chen, 2019, Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction, Andrologia, 51, 10.1111/and.13160 Choi, 2008, A new preparation protocol for measurement of testicular sperm production, J. Reprod. Dev., 54, 90, 10.1262/jrd.19123 Choowong-In, 2021, Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS, Andrologia, 53, 10.1111/and.13977 Creasy, 1997, Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging, Toxicol. Pathol., 25, 119, 10.1177/019262339702500201 Dominguez, 2005, Dopamine, the medial preoptic area, and male sexual behavior, Physiol. Behav., 86, 356, 10.1016/j.physbeh.2005.08.006 Fernandez-Pastor, 2019, Quantitative NMR analysis of L-Dopa in seeds from two varieties of Mucuna pruriens, Phytochem. Anal., 30, 89, 10.1002/pca.2793 Giuliano, 2001, Dopamine and male sexual function, Eur. Urol., 40, 601, 10.1159/000049844 Haider, 1985, Morphological and enzyme histochemical observations on alcohol induced disturbances in testis of two patients, Andrologia, 17, 532, 10.1111/j.1439-0272.1985.tb01709.x Heijkoop, 2018, Assessment of sexual behavior in rats: the potentials and pitfalls, Behav. Brain Res., 352, 70, 10.1016/j.bbr.2017.10.029 Horibe, 2019, Ethanol-induced autophagy in sertoli cells is specifically marked at androgen-dependent stages of the spermatogenic cycle: potential mechanisms and implications, Int. J. Mol. Sci., 20, 184, 10.3390/ijms20010184 Iamsaard, 2020, Evaluation of antioxidant capacity and reproductive toxicity of aqueous extract of Thai Mucuna pruriens seeds, J. Integr. Med., 18, 265, 10.1016/j.joim.2020.03.003 Iamsaard, 2014, Antioxidant activity and protective effect of Clitoria ternatea flower extract on testicular damage induced by ketoconazole in rats, J. Zhejiang Univ. - Sci. B, 15, 548, 10.1631/jzus.B1300299 Iamsaard, 2013, Anethum graveolens Linn. (dill) extract enhances the mounting frequency and level of testicular tyrosine protein phosphorylation in rats, J Zhejiang Univ Sci B., 14, 247, 10.1631/jzus.B1200287 Iamsaard, 2011, Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization, J. Cell. Physiol., 226, 2817, 10.1002/jcp.22626 Iamsaard, 2018, Methotrexate changes the testicular tyrosine phosphorylated protein expression and seminal vesicle epithelia of adult rats, J. Morphol., 36, 737 Johnson, 1983, Enhanced daily sperm production in the remaining testis of aged rats following hemicastration, J. Androl., 4, 162, 10.1002/j.1939-4640.1983.tb00743.x Kanazawa, 2000, High content of dopamine, a strong antioxidant, in Cavendish banana, J. Agric. Food Chem., 48, 844, 10.1021/jf9909860 Khosravanian, 2014, Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp70-2 protein expression and ameliorated biochemical alterations, J. Assist. Reprod. Genet., 31, 341, 10.1007/s10815-013-0165-0 Komārabhacca, 2015 Lampariello, 2012, The magic velvet bean of Mucuna pruriens, J. Tradi.t Complement. Med., 2, 331, 10.1016/S2225-4110(16)30119-5 Li, 2010, Adult exposure to sasanguasaponin induces spermatogenic cell apoptosis in vivo through increased oxidative stress in male mice, Toxicol. Ind. Health, 6, 691 Lin, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists, Bioorg. Med. Chem. Lett, 24, 3626, 10.1016/j.bmcl.2014.05.039 López, 2015, L-DOPA stabilization on sol-gel silica to be used as neurological nanoreservoirs: structural and spectroscopic studies, Mater. Lett., 161, 160, 10.1016/j.matlet.2015.08.015 Maneesh, 2006, Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males, Indian J. Physiol. Pharmacol., 50, 291 Margolesky, 2020, From Mucuna Pruriens to deep brain stimulation: a two-decade case history, Park. Relat. Disord., 77, 26, 10.1016/j.parkreldis.2020.06.014 Mennella, 2006, Short-term effects of alcohol consumption on the hormonal milieu and mood states in nulliparous women, Alcohol, 38, 29, 10.1016/j.alcohol.2006.03.006 Muthusami, 2005, Effect of chronic alcoholism on male fertility hormones and semen quality, Fertil. Steril., 84, 919, 10.1016/j.fertnstert.2005.04.025 Mutwedu, 2019, Effect of dietary inclusion of small quantities of Mucuna pruriens seed meal on sexual behavior, semen characteristics, and biochemical parameters in rabbit bucks (Oryctolagus cuniculus), Trop. Anim. Health Prod., 51, 1195, 10.1007/s11250-019-01808-2 Nayak, 2017, The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia, Neuroreport, 28, 1195, 10.1097/WNR.0000000000000888 Nishi, 2018, Protective effects of p-coumaric acid on ethanol induced male reproductive toxicity, Life Sci, 209, 1, 10.1016/j.lfs.2018.07.045 Oliva, 2006, Impairment of adult male reproductive function in rats exposed to ethanol since puberty, Reprod. Toxicol., 22, 599, 10.1016/j.reprotox.2006.04.017 Paiz, 2010, Glucose-lowering effect of xoconostle (Opuntia joconostle A. Web., Cactaceae) in diabetic mice, J. Med. Plants Res., 4, 2326 Pathania, 2020, An assessment of potential nutritive and medicinal properties of Mucuna pruriens: a natural food legume, 3 Biotech., 10, 261, 10.1007/s13205-020-02253-x Rai, 2020, Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective, 3 Biotech., 10, 522, 10.1007/s13205-020-02532-7 Reddy, 2015, Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats, Toxicol. Res., 4, 223, 10.1039/C4TX00121D Saba, 2009, Spermatozoa morphology and characteristics of male Wistar rats administered with ethanolic extract of Lagenaria Breviflora Roberts, Afr. J. Biotechnol., 8, 1170 Sadeghzadeh, 2018, The effect of chronic ethanol consumption on sexual motivation and behavior of adult male wistar rats in the copulatory phase, Addict Health, 10, 190 Sahin, 2016, Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats, BMC Compl. Alternative Med., 16, 318, 10.1186/s12906-016-1303-x Samat, 2014, Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats, BMC Compl. Alternative Med., 14, 146, 10.1186/1472-6882-14-146 Sampannang, 2019, Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: an experimental study, Int. J. Reprod. Biomed., 17, 567 Sawatpanich, 2018, Localization and changes of tyrosine phosphorylated proteins and ß actin in epididymis of rats treated with valproic acid, J. Morphol., 36, 835 Shukla, 2010, Mucuna pruriens reduces stress and improves the quality of semen in infertile men. Evid.-Based Complement, Alternative Med., 7, 137 Shukla, 2009, Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis, Fertil. Steril., 92, 1934, 10.1016/j.fertnstert.2008.09.045 Siervo, 2015, Spermatic and testicular damages in rats exposed to ethanol: influence of lipid peroxidation but not testosterone, Toxicology, 330, 118, 10.1016/j.tox.2015.01.016 Singh, 2013, Mucuna pruriens and its major constituent L-DOPA recover spermatogenic loss by combating ROS, loss of mitochondrial membrane potential and apoptosis, PLoS One, 8 Singh, 2013, An overview of the current methodologies used for evaluation of aphrodisiac agents, J. Acute Dis., 2, 85, 10.1016/S2221-6189(13)60105-5 Sinha, 2018, Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling, J. Ethnopharmacol., 217, 23, 10.1016/j.jep.2018.02.006 Sönmez, 2016, Protective effects of propolis on methotrexate-induced testis injury in rat, Biomed. Pharmacother., 79, 44, 10.1016/j.biopha.2016.02.002 Sukhorum, 2017, Changes in testicular function proteins and sperm acrosome status in rats treated with valproic acid, Reprod. Fertil. Dev., 29, 1585, 10.1071/RD16205 Suresh, 2012, Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat, J. Sex. Med., 9, 3066, 10.1111/j.1743-6109.2010.01831.x Suresh, 2009, Dose- and time-dependent effects of ethanolic extract of Mucuna pruriens Linn. seed on sexual behaviour of normal male rats, J. Ethnopharmacol., 122, 497, 10.1016/j.jep.2009.01.032 Suresh, 2013, Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction and DNA damage in epididymal sperm of streptozotocin induced diabetic rat, J. Ethnopharmacol., 145, 32, 10.1016/j.jep.2012.10.030 Tahir, 2011, Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities, Alcohol Alcohol, 46, 383, 10.1093/alcalc/agr038 Tangsrisakda, 2020, Effect of ethanol on the changes in testicular protein expression in adult male rats, Andrologia, 52, 10.1111/and.13784 Tongpan, 2019, Valproic acid changes the expression of tyrosine-phosphorylated proteins in rat seminal vesicle, Andrologia, 51, 10.1111/and.13303 Uygur, 2014, Effects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats, Andrologia, 46, 356, 10.1111/and.12085 Vendramini, 2014, Reproductive function of the male obese Zucker rats: alteration in sperm production and sperm DNA damage, Reprod. Sci., 21, 221, 10.1177/1933719113493511 Witkiewitz, 2012, Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility, Therapeut. Clin. Risk Manag., 8, 45, 10.2147/TCRM.S23184 World Health Organization, 2010 Woźniak, 2015, Ursolic acid--a pentacyclic triterpenoid with a wide spectrum of pharmacological activities, Molecules, 20, 20614, 10.3390/molecules201119721 Yahn, 2013, vol. 6, 1 Yannasithinon, 2021, Dolichandrone serrulata flower extract ameliorates male reproductive damages in type 2 diabetic rats, Andrologia, 53, 10.1111/and.13911 Yari, 2018, The protective effects of Arctium lappa L. extract on testicular injuries induced by ethanol in rats, Andrologia, 50, e13086, 10.1111/and.13086