Estrogen-containing hormone therapy and Alzheimer’s disease risk: Understanding discrepant inferences from observational and experimental research

Alkayed, 2000, Neuroprotective effects of female gonadal steroids in reproductively senescent female rats, Stroke, 31, 161, 10.1161/01.STR.31.1.161 Amaducci, 1986, Risk factors for clinically diagnosed Alzheimer’s disease, Neurology, 36, 922, 10.1212/WNL.36.7.922 Anderson, 2004, Effects of conjugated equine estrogen in postmenopausal women with hysterectomy, JAMA, 291, 1701, 10.1001/jama.291.14.1701 Asthana, 2001, High-dose estradiol improves cognition for women with AD, Neurology, 57, 605, 10.1212/WNL.57.4.605 Bagger, 2005, Early postmenopausal hormone replacement therapy may prevent cognitive impairment later in life, Menopause, 12, 12, 10.1097/00042192-200512010-00005 Baldereschi, 1998, Estrogen-replacement therapy and Alzheimer’s disease in the Italian Longitudinal Study on Aging, Neurology, 50, 996, 10.1212/WNL.50.4.996 Binder, 2001, Effects of hormone replacement therapy on cognitive performance in elderly women, Maturitas, 38, 137, 10.1016/S0378-5122(00)00214-0 Bishop, 1995, Estradiol enhances brain glucose uptake in ovariectomized rats, Brain Res Bull, 36, 315, 10.1016/0361-9230(94)00208-I Brenner, 1994, Postmenopausal estrogen replacement therapy and the risk of Alzheimer’s disease, Am J Epidemiol, 140, 262, 10.1093/oxfordjournals.aje.a117245 Brett, 2001 Brinton, 1997, Equilin, a principal component of the estrogen replacement therapy Premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism, Exp Neurol, 147, 211, 10.1006/exnr.1997.6619 Brinton, 1997, 17 β-Estradiol enhances the outgrowth and survival of neocortical neurons in culture, Neurochem Res, 22, 1339, 10.1023/A:1022015005508 Broe, 1990, A case-control study of Alzheimer’s disease in Australia, Neurology, 40, 1698, 10.1212/WNL.40.11.1698 Cushman, 1999, Effect of postmenopausal hormones on inflammation-sensitive proteins, Circulation, 100, 717, 10.1161/01.CIR.100.7.717 Derby, 1993, Correlates of postmenopausal estrogen use and trends through the 1980s in two southeastern New England communities, Am J Epidemiol, 137, 1125, 10.1093/oxfordjournals.aje.a116616 Doraiswamy, 1997, The Alzheimer’s disease assessment scale, Neurology, 48, 1511, 10.1212/WNL.48.6.1511 Elias, 2000, The preclinical phase of Alzheimer’s disease, Arch Neurol, 57, 808, 10.1001/archneur.57.6.808 Espeland, 2004, Conjugated equine estrogens and global cognitive function in postmenopausal women, JAMA, 291, 2959, 10.1001/jama.291.24.2959 Foy, 2000, Estrogen and neural plasticity, Curr Direct Psychol Sci, 9, 148, 10.1111/1467-8721.00081 Gao, 1998, The relationships between age, sex, and incidence of dementia and Alzheimer disease, Arch Gen Psychiatry, 55, 809, 10.1001/archpsyc.55.9.809 Gibbs, 2000, Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats, Neurobiol Aging, 21, 107, 10.1016/S0197-4580(00)00103-2 Gillum, 2000, Ischemic stroke risk with oral contraceptives, JAMA, 284, 72, 10.1001/jama.284.1.72 Goodman, 1996, Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons, J Neurochem, 66, 1836, 10.1046/j.1471-4159.1996.66051836.x Grady, 2002, Effect of postmenopausal hormone therapy on cognitive function, Am J Med, 113, 543, 10.1016/S0002-9343(02)01270-6 Graves, 1994, The epidemiology of dementia, 23 Hagnell, 1992, Incidence of dementia in the Lundby study, Neuroepidemiology, 11, 61, 10.1159/000110981 Hebert, 2003, Alzheimer disease in the US population, Arch Neurol, 60, 1119, 10.1001/archneur.60.8.1119 Henderson, 2000 Henderson, 2005, Postmenopausal hormone therapy and Alzheimer’s disease risk, J Neurol Neurosurg Psychiatry, 76, 103, 10.1136/jnnp.2003.024927 Henderson, 2003, Estrogen exposures and memory at midlife, Neurology, 60, 1369, 10.1212/01.WNL.0000059413.75888.BE Henderson, 1994, Estrogen replacement therapy in older women, Arch Neurol, 51, 896, 10.1001/archneur.1994.00540210068014 Henderson, 2000, Estrogen for Alzheimer’s disease in women, Neurology, 54, 295, 10.1212/WNL.54.2.295 Henderson, 1996, Cognitive skills associated with estrogen replacement in women with Alzheimer’s disease, Psychoneuroendocrinology, 21, 421, 10.1016/0306-4530(95)00060-7 Herrington, 2001, Estrogen replacement and brachial artery flow-mediated vasodilation in older women, Arterioscler Thromb Vasc Biol, 21, 1955, 10.1161/hq1201.100241 Heyman, 1984, Alzheimer’s disease, Ann Neurol, 15, 335, 10.1002/ana.410150406 Hodis, 2003, Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women, N Engl J Med, 349, 535, 10.1056/NEJMoa030830 Hodis, 2001, Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial, Ann Intern Med, 135, 939, 10.7326/0003-4819-135-11-200112040-00005 Hogervorst, 2000, The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women, Neuroscience, 101, 485, 10.1016/S0306-4522(00)00410-3 Jezierski, 2001, Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation, Neurobiol Aging, 22, 309, 10.1016/S0197-4580(00)00230-X Jorm, 1987, The prevalence of dementia, Acta Psychiatr Scand, 76, 465, 10.1111/j.1600-0447.1987.tb02906.x Kawas, 1997, A prospective study of estrogen replacement therapy and the risk of developing Alzheimer’s disease, Neurology, 48, 1517, 10.1212/WNL.48.6.1517 Kokmen, 1996, Epidemiology of dementia in Rochester, Minnesota, Mayo Clin Proc, 71, 275, 10.4065/71.3.275 Launer, 1999, Rates and risk factors for dementia and Alzheimer’s disease, Neurology, 52, 78, 10.1212/WNL.52.1.78 LeBlanc, 2001, Hormone replacement therapy and cognition, JAMA, 285, 1489, 10.1001/jama.285.11.1489 Lerner, 1997, Smoking and oestrogen-replacement therapy as protective factors for Alzheimer’s disease [letter], Lancet, 349, 403, 10.1016/S0140-6736(97)80025-6 Luine, 1985, Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats, Exp Neurol, 89, 484, 10.1016/0014-4886(85)90108-6 Mack, 2004, Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause, Fertil Steril, 82, 391, 10.1016/j.fertnstert.2004.01.034 Matthews, 1999, Estrogen replacement therapy and cognitive decline in older community women, J Am Geriatr Soc, 47, 518, 10.1111/j.1532-5415.1999.tb02563.x Matthews, 1996, Prior to use of estrogen replacement therapy, are users healthier than nonusers?, Am J Epidemiol, 143, 971, 10.1093/oxfordjournals.aje.a008678 McKinlay, 1992, The normal menopause transition, Maturitas, 14, 103, 10.1016/0378-5122(92)90003-M Meyer, 2003, A population-based longitudinal study of cognitive functioning in the menopausal transition, Neurology, 61, 801, 10.1212/01.WNL.0000079051.91602.E2 Mortel, 1995, Lack of postmenopausal estrogen replacement therapy and the risk of dementia, J Neuropsychiatry Clin Neurosci, 7, 334, 10.1176/jnp.7.3.334 Mulnard, 2000, Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease, JAMA, 283, 1007, 10.1001/jama.283.8.1007 Nilsen, 2003, Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling, Proc Natl Acad Sci USA, 100, 10506, 10.1073/pnas.1334098100 2004, Treatment of menopause-associated vasomotor symptoms, Menopause, 11, 11, 10.1097/01.GME.0000108177.85442.71 Ohkura, 1995, Estrogen increases cerebral and cerebellar blood flows in postmenopausal women, Menopause, 2, 13, 10.1097/00042192-199502010-00003 Paganini-Hill, 1996, Estrogen replacement therapy and risk of Alzheimer’s disease, Arch Intern Med, 156, 2213, 10.1001/archinte.1996.00440180075009 Petanceska, 2000, Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in brain, Neurology, 54, 2212, 10.1212/WNL.54.12.2212 Petersen, 2001, Current concepts in mild cognitive impairment, Arch Neurol, 58, 1985, 10.1001/archneur.58.12.1985 Phillips, 1992, Effects of estrogen on memory function in surgically menopausal women, Psychoneuroendocrinology, 17, 485, 10.1016/0306-4530(92)90007-T Rapp, 2003, The effect of estrogen with progestin treatment on global cognitive function in postmenopausal women, JAMA, 289, 2663, 10.1001/jama.289.20.2663 Rasool, 1986, Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer’s disease, Ann Neurol, 20, 482, 10.1002/ana.410200407 Resnick, 2002, Hormone therapy and risk of Alzheimer disease, JAMA, 288, 2170, 10.1001/jama.288.17.2170 Rigaud, 2003, No additional benefit of HRT on response to rivastigmine in menopausal women with AD, Neurology, 60, 148, 10.1212/WNL.60.1.148-a Rosendaal, 2002, Female hormones and thrombosis, Arterioscler Thromb Vasc Biol, 22, 201, 10.1161/hq0202.102318 Rossouw, 2002, Risks and benefits of estrogen plus progestin in healthy postmenopausal women, JAMA, 288, 321, 10.1001/jama.288.3.321 Savonenko, 2003, The cognitive effects of ovariectomy and estrogen replacement are modulated by aging, Neuroscience, 119, 821, 10.1016/S0306-4522(03)00213-6 Selkoe, 2001, Alzheimer’s disease, Physiol Rev, 81, 741, 10.1152/physrev.2001.81.2.741 Seshadri, 2001, Postmenopausal estrogen replacement therapy and the risk of Alzheimer’s disease, Arch Neurol, 58, 435, 10.1001/archneur.58.3.435 Shaywitz, 2003, Better oral reading and short-term memory in midlife, postmenopausal women taking estrogen, Menopause, 10, 420, 10.1097/01.GME.0000060241.02837.29 Shughrue, 1997, Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system, J Comp Neurol, 388, 507, 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6 Shughrue, 2000, Estrogen binding and estrogen receptor characterization (ERα and ERβ) in the cholinergic neurons of the rat basal forebrain, Neuroscience, 96, 41, 10.1016/S0306-4522(99)00520-5 Shumaker, 2004, Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women, JAMA, 291, 2947, 10.1001/jama.291.24.2947 Shumaker, 2003, Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women, JAMA, 289, 2651, 10.1001/jama.289.20.2651 Silva, 2003, Onset of estrogen replacement has a critical effect on synaptic density of CA1 hippocampus in ovariectomized adult rats, Menopause, 10, 406, 10.1097/01.GME.0000064816.74043.E9 Slooter, 1999, Estrogen use and early onset Alzheimer’s disease, J Neurol Neurosurg Psychiatry, 67, 779, 10.1136/jnnp.67.6.779 Small, 2000, The course of cognitive impairment in preclinical Alzheimer disease, Arch Neurol, 57, 839, 10.1001/archneur.57.6.839 Tang, 1996, Effect of oestrogen during menopause on risk and age at onset of Alzheimer’s disease, Lancet, 348, 429, 10.1016/S0140-6736(96)03356-9 Toran-Allerand, 2000, Estrogen as treatment for Alzheimer disease [letter], JAMA, 284, 307, 10.1001/jama.284.3.307 Toran-Allerand, 2004, Minireview: a plethora of estrogen receptors in the brain: where will it end, Endocrinology, 145, 1069, 10.1210/en.2003-1462 Torgerson, 2001, Hormone replacement therapy and prevention of nonvertebral fractures, JAMA, 285, 2891, 10.1001/jama.285.22.2891 Trévoux, 1986, Endometrium and plasma hormone profile in the peri-menopause and post-menopause, Maturitas, 8, 309, 10.1016/0378-5122(86)90039-3 Walsh, 1991, Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins, N Engl J Med, 325, 1196, 10.1056/NEJM199110243251702 Wang, 2000, Effects of estrogen on cognition, mood, and cerebral blood flow in AD, Neurology, 54, 2061, 10.1212/WNL.54.11.2061 Waring, 1999, Postmenopausal estrogen replacement therapy and risk of AD, Neurology, 52, 965, 10.1212/WNL.52.5.965 Wassertheil-Smoller, 2003, Effect of estrogen plus progestin on stroke in postmenopausal women: the Women’s Health Initiative: a randomized trial, JAMA, 289, 2673, 10.1001/jama.289.20.2673 Woods, 2000, Memory functioning among midlife women, Menopause, 7, 257, 10.1097/00042192-200007040-00008 Woolley, 1990, Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons, J Neurosci, 10, 4035, 10.1523/JNEUROSCI.10-12-04035.1990 Yaffe, 1998, Estrogen therapy in postmenopausal women, JAMA, 279, 688, 10.1001/jama.279.9.688 Zandi, 2002, Hormone replacement therapy and incidence of Alzheimer’s disease on older women, JAMA, 288, 2123, 10.1001/jama.288.17.2123 Zegura, 2003, Double blind, randomized study of estradiol replacement therapy on markers of inflammation, coagulation and fibrinolysis, Atherosclerosis, 168, 123, 10.1016/S0021-9150(03)00088-1 Zekry, 2002, Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly, Acta Neuropathol (Berl), 103, 481, 10.1007/s00401-001-0493-5