Using mice to model cognitive deficits in neurologic disorders: Narrowing in on Rett syndrome

Chen RZ, Akbarian S, Tudor M, Jaenish R: Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 2001, 27:327–331.

Dunn HG, MacLeod PM: Rett syndrome: review of biological abnormalities. Can J Neurol Sci 2001, 28:16–29.

Shahbazian MD, Zoghbi HY: Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations. Curr Opin Neurol 2001, 14:171–176.

Carter AR, Segal RA: Rett syndrome model suggests MECP2 gives neurons the quiet they need to think. Nat Neurosci 2001, 4:342–43.

Guy J, Hendrich B, Holmes M, et al.: A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 2001, 27:322–326.

Shahbazian MD, Young JI, Yuva-Paylor LA, et al.: Mice with truncated MeCP2 recapitulate many Rett Syndrome features and display hyperacetylation of histone H3.Neuron 2002, 35:243–254.

Crawley JN: What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. Hoboken, NJ: Wiley Press; 2000.

Stearns NA, Floerke-Nashner L, Berger-Sweeney J: Behavioral characterization of MECP2 mice—a Rett syndrome model. Soc Neurosci Abs 2002.

Self DW: Comparison of transgenic strategies for behavioral neuroscience studies in rodents. Psychopharmacology 1999, 147:35–37.

Schauwecker PE: Complications associated with genetic background effects in models of experimental epilepsy. Prog Brain Res 2002, 135:139–148.

Anagnostopoulos AV: It’s a knockout! Male infertility and neuropathology. Trends Genet 2002, 18:8–10.