Ginsenosides in Panax genus and their biosynthesis
Tài liệu tham khảo
Lee, 2004, Phylogeny of Panax using chloroplast trnC-trnD intergenic region and the utility of trnC-trnD in interspecific studies of plants, Mol Phylogenet Evol, 31, 894, 10.1016/j.ympev.2003.10.009
Sharma, 2009, A new species of panax L. (Araliaceae) from Sikkim himalaya, India, Syst Bot, 34, 434, 10.1600/036364409788606235
Duy, 2016, A new variety of panax (Araliaceae) from lam vien plateau, vietnam and its molecular evidence, Phytotaxa, 277, 47, 10.11646/phytotaxa.277.1.4
Pandey, 2012, Intraspecific variation in Panax assamicus Ban. populations based on internal transcribed spacer (ITS) sequences of nrDNA, Indian J Biotechnol, 11, 30
Gurung, 2018, Major ginsenoside contents in rhizomes of Panax sokpayensis and Panax bipinnatifidus, Nat Prod Res, 32, 234, 10.1080/14786419.2017.1343322
Tung, 2011, Oleanolic triterpene saponins from the roots of Panax bipinnatifidus, Chem Pharm Bull, 59, 1417, 10.1248/cpb.59.1417
Chen, 2020, Comparison of ginsenoside components of various tissues of New Zealand forest-grown Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolium L.), Biomolecules, 10, 372, 10.3390/biom10030372
Zhu, 2004, Comparative study on triterpene saponins of ginseng drugs, Planta Med, 70, 666, 10.1055/s-2004-827192
Wan, 2006, Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD, J Pharmaceut Biomed Anal, 41, 1596, 10.1016/j.jpba.2006.01.058
Jia, 2013, Comparative studies of saponins in 1‒3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples, J Nat Med, 67, 339, 10.1007/s11418-012-0691-6
Tanaka, 1985, Study on saponins of rhizomes of Panax pseudo-ginseng subsp. himalaicus collected at Tzatogang and Pari-la, Bhutan-Himalaya, Chem Pharm Bull, 33, 2323, 10.1248/cpb.33.2323
Morita, 1983, Chemical and morphological study on Chinese Panax japonicus C. A. MEYER (Zhujie-Shen), Chem Pharm Bull, 31, 3205, 10.1248/cpb.31.3205
Biswas, 2015, A dual purpose cell line of an Indian congener of ginseng-Panax sikkimensis with distinct ginsenoside and anthocyanin production profiles, Protoplasma, 252, 697, 10.1007/s00709-014-0695-z
Lee, 1981, Two-dimensional TLC analysis of ginsenosides from root of dwarf ginseng (panax trifolius L.) Araliaceae, J Pharm Sci, 70, 89, 10.1002/jps.2600700119
Le, 2015, Ginseng saponins in different parts of Panax vietnamensis, Chem Pharm Bull, 63, 950, 10.1248/cpb.c15-00369
Venugopal, 2011, Relationship between age, size, fecundity and climatic factors in Panax wangianus an endangered medicinal plant in the sacred grove forest of North-East India, J Forestry Res, 22, 427, 10.1007/s11676-011-0115-6
Morita, 1985, Saponin composition of rhizomes of Panax japonicus collected in South Kyushu, Japan, and its significance in oriental traditional medicine, Chem Pharm Bull, 33, 3852, 10.1248/cpb.33.3852
Shu, 2021, Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus, J Ginseng Res, 45, 305, 10.1016/j.jgr.2020.05.002
Morita, 1986, Saponins of plants of Panax species collected in Central Nepal and their chemotaxonomical significance. II, Chem Pharm Bull, 34, 4368, 10.1248/cpb.34.4368
Baeg, 2013, The world ginseng market and the ginseng, J Ginseng Res, 37, 1, 10.5142/jgr.2013.37.1
Yang, 2018, Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments, Pharmacol Res, 134, 1, 10.1016/j.phrs.2018.05.005
Zhang, 2015, Resource investigation of traditional medicinal plant Panax japonicus (T.Nees) C.A. Mey and its varieties in China, J Ethnopharmacol, 166, 79, 10.1016/j.jep.2015.02.051
Yang, 2018, Identification and quality analysis of Panax notoginseng and Panax vietnamensis var. fuscidicus through integrated DNA barcoding and HPLC, CHM, 10, 177
Tang, 2019, Transcriptome analysis of Panax zingiberensis identifies genes encoding oleanolic acid glucuronosyltransferase involved in the biosynthesis of oleanane-type ginsenosides, Planta, 249, 393, 10.1007/s00425-018-2995-6
Yang, 2014, Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity, Phytochemistry, 106, 7, 10.1016/j.phytochem.2014.07.012
Li, 2019, Dammarane-type triterpene oligoglycosides from the leaves and stems of Panax notoginseng and their antiinflammatory activities, J Ginseng Res, 43, 377, 10.1016/j.jgr.2017.11.008
Im, 2020, Pro-resolving effect of ginsenosides as an anti-inflammatory mechanism of Panax ginseng, Biomolecules, 10, 444, 10.3390/biom10030444
Gao, 2020, Ginsenoside Rg1 prevent and treat inflammatory diseases: A review, Int Immunopharm, 87, 106805, 10.1016/j.intimp.2020.106805
Wong, 2015, Recent advances in ginseng as cancer therapeutics: A functional and mechanistic overview, Nat Prod Rep, 32, 256, 10.1039/C4NP00080C
Sun, 2017, Anticancer effects of ginsenoside Rg3, Int J Mol Med, 39, 507, 10.3892/ijmm.2017.2857
Li, 2020, Anticancer property of ginsenoside Rh2 from ginseng, Eur J Med Chem, 203, 112627, 10.1016/j.ejmech.2020.112627
Zhou, 2019, Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis, Cells, 8, 204, 10.3390/cells8030204
Bai, 2018, Therapeutic potential of ginsenosides as an adjuvant treatment for diabetes, Front Pharmacol, 9, 423, 10.3389/fphar.2018.00423
Nabavi, 2015, Ginsenoside Rd and ischemic stroke; A short review of literatures, J Ginseng Res, 39, 299, 10.1016/j.jgr.2015.02.002
Peng, 2012, Ginsenoside Re: Pharmacological effects on cardiovascular system, Cardiovasc Ther, 30, e183, 10.1111/j.1755-5922.2011.00271.x
Gao, 2017, Hepataprotective effects of ginsenoside Rg—a review, J Ethnopharmacol, 206, 178, 10.1016/j.jep.2017.04.012
Shin, 2016, Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β3 in thrombin-induced human platelets, J Ginseng Res, 40, 359, 10.1016/j.jgr.2015.11.003
Liu, 2019, Phospholipase Cγ2 signalling contributes to the haemostatic effect of notoginsenoside Ft1, J Pharm Pharmacol, 71, 878, 10.1111/jphp.13057
Tran, 2002, Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis), Planta Med, 68, 402, 10.1055/s-2002-32069
Ahmed, 2016, Ginsenoside Rb1 as a neuroprotective agent: A review, Brain Res Bull, 125, 30, 10.1016/j.brainresbull.2016.04.002
Li, 2019, Current status and problem-solving strategies for ginseng industry, Chin J Integr Med, 25, 883, 10.1007/s11655-019-3046-2
Adil, 2018, In vitro cultivation of Panax ginseng C.A. Meyer, Ind Crop Prod, 122, 239, 10.1016/j.indcrop.2018.05.076
Shin, 2015, Chemical diversity of ginseng saponins from Panax ginseng, J Ginseng Res, 39, 287, 10.1016/j.jgr.2014.12.005
Wang, 2016, Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review, J Ethnopharmacol, 188, 234, 10.1016/j.jep.2016.05.005
Xu, 2019, Analytical methods and biological activities of Panax notoginseng saponins: Recent trends, J Ethnopharmacol, 236, 443, 10.1016/j.jep.2019.02.035
Wang, 2015, Chemical analysis of Panax quinquefolius (North American ginseng): A review, J Chromatogr A, 1426, 1, 10.1016/j.chroma.2015.11.012
Yang, 2021, Phytochemical analysis of Panax species: a review, J Ginseng Res, 45, 1, 10.1016/j.jgr.2019.12.009
Liu, 2017, Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins, J Ginseng Res, 41, 373, 10.1016/j.jgr.2017.01.001
Peng, 2018, Stereoisomers of saponins in Panax notoginseng (sanqi): A review, Front Pharmacol, 9, 188, 10.3389/fphar.2018.00188
Paek, 2009, Large scale culture of ginseng adventitious roots for production of ginsenosides, Adv Biochem Eng Biotechnol, 113, 151
Murthy, 2014, Ginsenosides: Prospective for sustainable biotechnological production, Appl Microbiol Biotechnol, 98, 6243, 10.1007/s00253-014-5801-9
Lu, 2018, Advances in ginsenoside biosynthesis and metabolic regulation, Biotechnol Appl Biochem, 65, 514, 10.1002/bab.1649
Gantait, 2020, Biotechnological interventions for ginsenosides production, Biomolecules, 10, 538, 10.3390/biom10040538
Rahimi, 2015, Production of ginseng saponins: Elicitation strategy and signal transductions, Appl Microbiol Biotechnol, 99, 6987, 10.1007/s00253-015-6806-8
Kim, 2015, Biosynthesis and biotechnological production of ginsenosides, Biotechnol Adv, 33, 717, 10.1016/j.biotechadv.2015.03.001
Wen, 1996, Phylogeny and biogeography of Panax L. (the ginseng genus, Araliaceae) inferences from ITS sequences of nuclear ribosomal DNA, Mol Phylogenet Evol, 6, 167, 10.1006/mpev.1996.0069
Choi, 2000, A phylogenetic analysis of Panax (Araliaceae) integrating cpDNA restriction site and nuclear rDNA ITS sequence data, Plant Systemat Evol, 224, 109, 10.1007/BF00985269
Zhu, 2003, Phylogenetic relationship in the genus Panax: Inferred from chloroplast trnK gene and nuclear 18S rRNA gene sequences, Planta Med, 69, 647, 10.1055/s-2003-41117
Zuo, 2011, DNA barcoding of Panax species, Planta Med, 77, 182, 10.1055/s-0030-1250166
Zuo, 2015, Evolutionary radiation of the Panax bipinnatifidus species complex (Araliaceae) in the Sino-Himalayan region of eastern Asia as inferred from AFLP analysis, J Systemat Evol, 53, 210, 10.1111/jse.12119
Zhou, 2020, Resolving complicated relationships of the Panax bipinnatifidus complex in southwestern China by RAD-seq data, Mol Phylogenet Evol, 149, 106851, 10.1016/j.ympev.2020.106851
Zuo, 2017, Intercontinental and intracontinental biogeography of the eastern Asian-Eastern North American disjunct Panax (the ginseng genus, Araliaceae), emphasizing its diversification processes in eastern Asia, Mol Phylogenet Evol, 117, 60, 10.1016/j.ympev.2017.06.016
Shi, 2015, The impacts of polyploidy, geographic and ecological isolations on the diversification of Panax (Araliaceae), BMC Plant Biol, 15, 297, 10.1186/s12870-015-0669-0
Zhang, 2016, Saponins from Panax bipinnatifidus Seem.: New strategy of extraction, isolation, and evaluation of tyrosinase inhibitory activity based on mathematical calculations, J Chromatogr B, 1039, 79, 10.1016/j.jchromb.2016.10.043
Liu, 2018, Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high performance liquid chromatography coupled with UV detector, J Ginseng Res, 42, 149, 10.1016/j.jgr.2017.01.007
Yang, 2016, Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers, Acta Pharm Sin B, 6, 568, 10.1016/j.apsb.2016.05.005
Qiu, 2017, Malonylginsenosides with potential antidiabetic activities from the flower buds of Panax ginseng, J Nat Prod, 80, 899, 10.1021/acs.jnatprod.6b00789
Shi, 2017, An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for the comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng, Anal Chim Acta, 952, 59, 10.1016/j.aca.2016.11.032
Li, 2017, Chemical and bioactive comparison of flowers of Panax ginseng Meyer, Panax quinquefolius L., and Panax notoginseng Burk, J Ginseng Res, 41, 487, 10.1016/j.jgr.2016.08.008
Wang, 2016, Complete 1H-NMR and 13C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng, J Ginseng Res, 40, 245, 10.1016/j.jgr.2015.08.003
Shin, 2019, Change of ginsenoside profiles in processed ginseng by drying, steaming, and puffing, J Microbiol Biotechnol, 29, 222, 10.4014/jmb.1809.09056
Yang, 2020, Insights into gastrointestinal microbiota-generated ginsenoside metabolites and their bioactivities, Drug Metab Rev, 52, 125, 10.1080/03602532.2020.1714645
Kim, 2018, An insight into ginsenoside metabolite compound K as a potential tool for skin disorder, Evid Based Complement Alternat Med, 2018, 8075870, 10.1155/2018/8075870
Sharma, 2020, Ginsenoside compound K: Insights into recent studies on pharmacokinetics and health-promoting activities, Biomolecules, 10, 1028, 10.3390/biom10071028
Elshafay, 2017, Ginsenoside Rk1 bioactivity: A systematic review, Peer J, 5, e3993, 10.7717/peerj.3993
Choi, 2015, Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1, J Funct Foods, 14, 613, 10.1016/j.jff.2015.02.038
Jo, 2014, Preparation of ginsenosides Rg3, Rk1, and Rg5-selectively enriched ginsengs by a simple steaming process, Eur Food Res Technol, 240, 251, 10.1007/s00217-014-2370-1
He, 2017, 20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion, Bioorg Med Chem Lett, 27, 3867, 10.1016/j.bmcl.2017.06.045
Lv, 2016, Antitumoral activity of (20R)- and (20S)-ginsenoside Rh2 on transplanted hepatocellular carcinoma in mice, Planta Med, 82, 705, 10.1055/s-0042-101764
Zhang, 2016, Notoginsenoside Ft1 promotes fibroblast proliferation via PI3K/Akt/mTOR signaling pathway and benefits wound healing in genetically diabetic mice, J Pharmacol Exp Ther, 356, 324, 10.1124/jpet.115.229369
Shen, 2014, Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries, Biochem Pharmacol, 88, 66, 10.1016/j.bcp.2014.01.007
Wang, 2018, Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng, J Ginseng Res, 42, 270, 10.1016/j.jgr.2016.08.009
Piao, 2020, Diversity of ginsenoside profiles produced by various processing technologies, Molecules, 25, 4390, 10.3390/molecules25194390
Tam, 2018, Ginsenoside Rh1: A systematic review of its pharmacological properties, Planta Med, 84, 139, 10.1055/s-0043-124087
Han, 2010, Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng, Phytochemistry, 71, 36, 10.1016/j.phytochem.2009.09.031
Tansakul, 2006, Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng, FEBS Lett, 580, 5143, 10.1016/j.febslet.2006.08.044
Huang, 2015, Production of oleanane-type sapogenin in transgenic rice via expression of β-amyrin synthase gene from Panax japonicus C. A. Mey, BMC Biotechnol, 15, 45, 10.1186/s12896-015-0166-4
Jiang, 2017, Molecular cloning and functional analysis of squalene synthase (SS) in Panax notoginseng, Int J Biol Macromol, 95, 658, 10.1016/j.ijbiomac.2016.11.070
Zhao, 2014, Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis, Plant Cell Rep, 33, 393, 10.1007/s00299-013-1538-7
Dellas, 2013, Discovery of a metabolic alternative to the classical mevalonate pathway, eLife, 2, 10.7554/eLife.00672
Henry, 2015, Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants, Proc Natl Acad Sci U S A, 112, 10050, 10.1073/pnas.1504798112
Deng, 2017, Enhancement of triterpenoid saponins biosynthesis in Panax notoginseng cells by co-overexpressions of 3-hydroxy-3-methylglutaryl CoA reductase and squalene synthase genes, Biochem Eng J, 122, 38, 10.1016/j.bej.2017.03.001
Kim, 2014, Functional analysis of 3-hydroxy-3-methylglutaryl coenzyme a reductase encoding genes in triterpene saponin-producing ginseng, Plant Physiol, 165, 373, 10.1104/pp.113.222596
Kim, 2014, Enhanced triterpene accumulation in Panax ginseng hairy roots overexpressing mevalonate-5-pyrophosphate decarboxylase and farnesyl pyrophosphate synthase, ACS Synth Biol, 3, 773, 10.1021/sb400194g
Niu, 2014, Expression profiling of the triterpene saponin biosynthesis genes FPS, SS, SE, and DS in the medicinal plant Panax notoginseng, Gene, 533, 295, 10.1016/j.gene.2013.09.045
Xu, 2018, Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng, Ind Crop Prod, 119, 132, 10.1016/j.indcrop.2018.04.010
Kim, 2011, Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng, Plant Cell Physiol, 52, 125, 10.1093/pcp/pcq179
Xu, 2017, Panax ginseng genome examination for ginsenoside biosynthesis, GigaScience, 6, 1, 10.1093/gigascience/gix093
Kim, 2018, Genome and evolution of the shade-requiring medicinal herb Panax ginseng, Plant Biotechnol J, 16, 1904, 10.1111/pbi.12926
Jiang, 2021, The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis, Plant Communications, 2, 100113, 10.1016/j.xplc.2020.100113
Xia, 2019, Structure and location studies on key enzymes in saponins biosynthesis of Panax notoginseng, Int J Mol Sci, 20, 6121, 10.3390/ijms20246121
Augustin, 2011, Molecular activities, biosynthesis and evolution of triterpenoid saponins, Phytochemistry, 72, 435, 10.1016/j.phytochem.2011.01.015
Xue, 2012, Divergent evolution of oxidosqualene cyclases in plants, New Phytol, 193, 1022, 10.1111/j.1469-8137.2011.03997.x
Thimmappa, 2014, Triterpene biosynthesis in plants, Annu Rev Plant Biol, 65, 225, 10.1146/annurev-arplant-050312-120229
Hu, 2013, Molecular cloning, expression, purification, and functional characterization of dammarenediol synthase from Panax ginseng, BioMed Res Int, 2013, 285740, 10.1155/2013/285740
Wang, 2014, The isolation and characterization of dammarenediol synthase gene from Panax quinquefolius and its heterologous co-expression with cytochrome P450 gene PqD12H in yeast, Funct Integr Genom, 14, 545, 10.1007/s10142-014-0384-1
Kim, 2009, Characterization of a dammarenediol synthase in Centella asiatica (L.) Urban, Plant Physiol Biochem, 47, 998, 10.1016/j.plaphy.2009.08.001
Han, 2006, Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng, Plant Cell Physiol, 47, 1653, 10.1093/pcp/pcl032
Shan, 2005, Enzymatic cyclization of dioxidosqualene to heterocyclic triterpenes, J Am Chem Soc, 127, 18008, 10.1021/ja055822g
Andre, 2016, Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids, New Phytol, 211, 1279, 10.1111/nph.13996
Wang, 2010, Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: Enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids, J Biol Chem, 285, 29703, 10.1074/jbc.M109.098871
Abe, 2007, Enzymatic synthesis of cyclic triterpenes, Nat Prod Rep, 24, 1311, 10.1039/b616857b
Jo, 2017, β-Amyrin synthase (EsBAS) and β-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus, Phytochemistry, 135, 53, 10.1016/j.phytochem.2016.12.011
Gao, 2015, Cloning and analysis of β-amyrin synthase gene in Bupleurum chinense, Genes Genom, 37, 767, 10.1007/s13258-015-0307-0
Chen, 2013, Cloning and characterization of the gene encoding β-amyrin synthase in the glycyrrhizic acid biosynthetic pathway in Glycyrrhiza uralensis, Acta Pharm Sin B, 3, 416, 10.1016/j.apsb.2013.09.002
Yu, 2013, Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis, Phytochemistry, 91, 122, 10.1016/j.phytochem.2012.05.002
Um, 2017, Functional characterization of the β-amyrin synthase gene involved in platycoside biosynthesis in Platycodon grandiflorum, Hortic Environ Biotechnol, 58, 613, 10.1007/s13580-017-0054-z
Kushiro, 2000, Mutational studies on triterpene synthases: Engineering lupeo synthase into β-amyrin synthase, J Am Chem Soc, 122, 6816, 10.1021/ja0010709
Zhang, 2019, Oleanane-type saponins biosynthesis in Panax notoginseng via transformation of β-amyrin synthase gene from Panax japonicus, J Agric Food Chem, 67, 1982, 10.1021/acs.jafc.8b07183
Zhao, 2015, Functional analysis of β-amyrin synthase gene in ginsenoside biosynthesis by RNA interference, Plant Cell Rep, 34, 1307, 10.1007/s00299-015-1788-7
Urlacher, 2012, Cytochrome P450 monooxygenases: An update on perspectives for synthetic application, Trends Biotechnol, 30, 26, 10.1016/j.tibtech.2011.06.012
Bathe, 2019, Cytochrome P450 enzymes: A driving force of plant diterpene diversity, Phytochemistry, 161, 149, 10.1016/j.phytochem.2018.12.003
Nelson, 2011, A P450-centric view of plant evolution, Plant J, 66, 194, 10.1111/j.1365-313X.2011.04529.x
Han, 2011, The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng, Plant Cell Physiol, 52, 2062, 10.1093/pcp/pcr150
Han, 2012, Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol-II during ginsenoside biosynthesis in Panax Ginseng, Plant Cell Physiol, 53, 1535, 10.1093/pcp/pcs106
Han, 2013, The involvement of β-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng, Plant Cell Physiol, 54, 2034, 10.1093/pcp/pct141
Fukushima, 2011, CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis, Plant Cell Physiol, 52, 2050, 10.1093/pcp/pcr146
Carelli, 2011, Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins, Plant Cell, 23, 3070, 10.1105/tpc.111.087312
Moses, 2015, Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata, Mol Plant, 8, 122, 10.1016/j.molp.2014.11.004
Tamura, 2017, CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis, Plant Cell Rep, 36, 437, 10.1007/s00299-016-2092-x
Huang, 2012, Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus, Planta, 236, 1571, 10.1007/s00425-012-1712-0
Gantt, 2011, Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions, Nat Chem Biol, 7, 685, 10.1038/nchembio.638
Bar-Peled, 2011, Plant nucleotide sugar formation, interconversion, and salvage by sugar recycling, Annu Rev Plant Biol, 62, 127, 10.1146/annurev-arplant-042110-103918
Tiwari, 2016, Plant secondary metabolism linked glycosyltransferases: An update on expanding knowledge and scopes, Biotechnol Adv, 34, 714, 10.1016/j.biotechadv.2016.03.006
Rahimi, 2019, Triterpenoid-biosynthetic UDP-glycosyltransferases from plants, Biotechnol Adv, 37, 107394, 10.1016/j.biotechadv.2019.04.016
Seki, 2015, P450s and UGTs: Key players in the structural diversity of triterpenoid saponins, Plant Cell Physiol, 56, 1463, 10.1093/pcp/pcv062
Osmani, 2009, Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling, Phytochemistry, 70, 325, 10.1016/j.phytochem.2008.12.009
Yan, 2014, Production of bioactive ginsenoside compound K in metabolically engineered yeast, Cell Res, 24, 770, 10.1038/cr.2014.28
Wei, 2015, Characterization of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts, Mol Plant, 8, 1412, 10.1016/j.molp.2015.05.010
Yang, 2020, The unprecedented diversity of UGT94-family UDP-glycosyltransferases in Panax plants and their contribution to ginsenoside biosynthesis, Sci Rep, 10, 15394, 10.1038/s41598-020-72278-y
Jung, 2014, Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd, Plant Cell Physiol, 55, 2177, 10.1093/pcp/pcu147
Wang, 2015, Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts, Metab Eng, 29, 97, 10.1016/j.ymben.2015.03.003
Lu, 2017, Functional regulation of a UDP-glucosyltransferase gene (Pq3-O-UGT1) by RNA interference and overexpression in Panax quinquefolius, Plant Cell Tissue Organ Cult, 129, 445, 10.1007/s11240-017-1190-y
Lu, 2017, Functional regulation of ginsenoside biosynthesis by RNA interferences of a UDP-glycosyltransferase gene in Panax ginseng and Panax quinquefolius, Plant Physiol Biochem, 111, 67, 10.1016/j.plaphy.2016.11.017
Lu, 2018, Characterization of UDP-glycosyltransferase involved in biosynthesis of ginsenosides Rg1 and Rb1 and identification of critical conserved amino acid residues for its function, J Agric Food Chem, 66, 9446, 10.1021/acs.jafc.8b02544
Wang, 2020, Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of Panax notoginseng using a synthetic biology platform, Metab Eng, 61, 131, 10.1016/j.ymben.2020.05.007
Yu, 2019, Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes, J Ginseng Res, 43, 116, 10.1016/j.jgr.2017.09.005
Meesapyodsuk, 2007, Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding β-amyrin synthase and a triterpene carboxylic acid glucosyltransferase, Plant Physiol, 143, 959, 10.1104/pp.106.088484
Chen, 2017, Whole-genome sequencing and analysis of the Chinese herbal plant Panax notoginseng, Mol Plant, 10, 899, 10.1016/j.molp.2017.02.010
Zhang, 2017, The medicinal herb Panax notoginseng genome provides insights into ginsenoside biosynthesis and genome evolution, Mol Plant, 10, 903, 10.1016/j.molp.2017.02.011
Rai, 2016, RNA-seq transcriptome analysis of Panax japonicus, and its comparison with other Panax species to identify potential genes involved in the saponins biosynthesis, Front Plant Sci, 7, 481, 10.3389/fpls.2016.00481
Wang, 2016, Transcriptome profiling shows gene regulation patterns in ginsenoside pathway in response to methyl jasmonate in Panax quinquefolium adventitious root, Sci Rep, 6, 37263, 10.1038/srep37263
Zhang, 2015, Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers, BMC Genom, 16, 159, 10.1186/s12864-015-1332-8
Gurung, 2016, Subtractive transcriptome analysis of leaf and rhizome reveals differentially expressed transcripts in Panax sokpayensis, Funct Integr Genom, 16, 619, 10.1007/s10142-016-0517-9
Wei, 2020, Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng, J Ginseng Res, 44, 757, 10.1016/j.jgr.2019.05.009
Bontpart, 2015, BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds, New Phytol, 208, 695, 10.1111/nph.13498
Paulsmeyer, 2018, Discovery of anthocyanin acyltransferase1 (AAT1) in maize using genotyping-by-sequencing (GBS), G3, 8, 3669, 10.1534/g3.118.200630
Kim, 2009, Molecular characterization of flavonoid malonyltransferase from Oryza sativa, Plant Physiol Biochem, 47, 991, 10.1016/j.plaphy.2009.08.004
Dhaubhadel, 2008, Identification and characterization of isoflavonoid specific glycosyltransferase and malonyltransferase from soybean seeds, J Exp Bot, 59, 981, 10.1093/jxb/ern046
Ahmad, 2017, Isoflavone malonyltransferases GmIMaT1 and GmIMaT3 differently modify isoflavone glucosides in soybean (Glycine max) under various stresses, Front Plant Sci, 8, 735, 10.3389/fpls.2017.00735
Sun, 2013, Discovery of WRKY transcription factors through transcriptome analysis and characterization of a novel methyl jasmonate-inducible PqWRKY1 gene from Panax quinquefolius, Plant Cell Tissue Organ Cult, 114, 269, 10.1007/s11240-013-0323-1
Chu, 2018, Genome-wide characterization and analysis of bHLH transcription factors in Panax ginseng, Acta Pharm Sin B, 8, 666, 10.1016/j.apsb.2018.04.004
Liu, 2019, PgMYB2, a MeJA-responsive transcription factor, positively regulates the dammarenediol synthase gene expression in Panax ginseng, Int J Mol Sci, 20, 2219, 10.3390/ijms20092219
Fonseca, 2009, (+)-7-iso-Jasmonoyl-l-isoleucine is the endogenous bioactive jasmonate, Nat Chem Biol, 5, 344, 10.1038/nchembio.161
Staswick, 2004, The oxylipin signal jasmonic acid is activated by an enzyme that conjugates it to isoleucine in Arabidopsis, Plant Cell, 16, 2117, 10.1105/tpc.104.023549
Monte, 2019, A single JAZ repressor controls the jasmonate pathway in Marchantia polymorpha, Mol Plant, 12, 185, 10.1016/j.molp.2018.12.017
Robert-Seilaniantz, 2011, Hormone crosstalk in plant disease and defense: More than just jasmonate-salicylate antagonism, Annu Rev Phytopathol, 49, 317, 10.1146/annurev-phyto-073009-114447
Ku, 2018, Plant hormone signaling crosstalks between biotic and abiotic stress responses, Int J Mol Sci, 19, 3206, 10.3390/ijms19103206
Zhang, 2017, Molecular cloning and characterization of PnbHLH1 transcription factor in Panax notoginseng, Molecules, 22, 1268, 10.3390/molecules22081268
Xiu, 2016, Molecular cloning and expression analysis of eight PgWRKY genes in Panax ginseng responsive to salt and hormones, Int J Mol Sci, 17, 319, 10.3390/ijms17030319
Wang, 2019, Effect of temperature on morphology, ginsenosides biosynthesis, functional genes, and transcriptional factors expression in Panax ginseng adventitious roots, J Food Biochem, 43
Afrin, 2015, Molecular cloning and expression profile of an abiotic stress and hormone responsive MYB transcription factor gene from Panax ginseng, Acta Biochim Biophys Sin, 47, 267, 10.1093/abbs/gmv012
Deng, 2017, An AP2/ERF family transcription factor PnERF1 raised the biosynthesis of saponins in Panax notoginseng, J Plant Growth Regul, 36, 691, 10.1007/s00344-017-9672-z
Wang, 2015, Identification of mRNA-like non-coding RNAs and validation of a mighty one named MAR in Panax ginseng, J Integr Plant Biol, 57, 256, 10.1111/jipb.12239
Wu, 2012, High-throughput sequencing and characterization of the small RNA transcriptome reveal features of novel and conserved microRNAs in Panax ginseng, PLoS One, 7
Wei, 2015, Identification of novel and conserved microRNAs in Panax notoginseng roots by high-throughput sequencing, BMC Genom, 16, 835, 10.1186/s12864-015-2010-6
Zheng, 2017, Small RNA profiles from Panax notoginseng roots differing in sizes reveal correlation between miR156 abundances and root biomass levels, Sci Rep, 7, 9418, 10.1038/s41598-017-09670-8
Mathur, 2010, Growth kinetics and ginsenosides production in transformed hairy roots of American ginseng-Panax quinquefolium L, Biotechnol Lett, 32, 457, 10.1007/s10529-009-0158-3
Thanh, 2005, Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-L balloon type bubble bioreactors, Appl Microbiol Biotechnol, 67, 197, 10.1007/s00253-004-1759-3
Gao, 2005, Induction and characterization of adventitious roots directly from the explants of Panax notoginseng, Biotechnol Lett, 27, 1771, 10.1007/s10529-005-3553-4
Wu, 1999, Production of ginseng and its bioactive components in plant cell culture: Current technological and applied aspects, J Biotechnol, 68, 89, 10.1016/S0168-1656(98)00195-3
Yu, 2001, Effects of macro elements and nitrogen source on adventitious root growth and ginsenoside production in ginseng, J Plant Biol, 44, 179, 10.1007/BF03030349
Yu, 2005, Ginsenoside production by hairy root cultures of Panax ginseng: Influence of temperature and light quality, Biochem Eng J, 23, 53, 10.1016/j.bej.2004.07.001
Li, 2017, Jasmonic acid and methyl dihydrojasmonate enhance saponin biosynthesis as well as expression of functional genes in adventitious roots of Panax notoginseng F.H. Chen, Biotechnol Appl Biochem, 64, 225, 10.1002/bab.1477
Kim, 2004, Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate, Biotechnol Lett, 26, 1619, 10.1007/s10529-004-3183-2
Hu, 2007, Role of jasmonic acid in alteration of ginsenoside heterogeneity in elicited cell cultures of Panax notoginseng, J Biosci Bioeng, 104, 513, 10.1263/jbb.104.513
Kochan, 2019, Abscisic acid regulates the 3-hydroxy-3-methylglutaryl CoA reductase gene promoter and ginsenoside production in Panax quinquefolium hairy root cultures, Int J Mol Sci, 20, 1310, 10.3390/ijms20061310
Biswas, 2018, Salicylic acid and ultrasonic stress modulated gene expression and ginsenoside production in differentially affected Panax quinquefolius (L.) and Panax sikkimensis (Ban.) cell suspensions, Plant Cell Tissue Organ Cult, 136, 575, 10.1007/s11240-018-01538-7
Dewir, 2010, Influences of polyunsaturated fatty acids (PUFAs) on growth and secondary metabolite accumulation in Panax ginseng C.A. Meyer adventitious roots cultured in air-lift bioreactors, S Afr J Bot, 76, 354, 10.1016/j.sajb.2009.10.008
Kochan, 2017, Yeast extract stimulates ginsenoside production in hairy root cultures of American ginseng cultivated in shake flasks and nutrient sprinkle bioreactors, Molecules, 22, 880, 10.3390/molecules22060880
Yu, 2016, Pathogenic fungal elicitors enhance ginsenoside biosynthesis of adventitious roots in Panax quinquefolius during bioreactor culture, Ind Crop Prod, 94, 729, 10.1016/j.indcrop.2016.09.058
Le, 2018, Biotic elicitation of ginsenoside metabolism of mutant adventitious root culture in Panax ginseng, Appl Microbiol Biotechnol, 102, 1687, 10.1007/s00253-018-8751-9
Ali, 2006, Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors, Plant Cell Rep, 25, 613, 10.1007/s00299-005-0065-6
Tewari, 2011, Salicylic acid-induced nitric oxide and ROS generation stimulate ginsenoside accumulation in Panax ginseng roots, J Plant Growth Regul, 30, 396, 10.1007/s00344-011-9202-3
Bae, 2006, Enhanced ginsenoside productivity by combination of ethephon and methyl jasmoante in ginseng (Panax ginseng C.A. Meyer) adventitious root cultures, Biotechnol Lett, 28, 1163, 10.1007/s10529-006-9071-1
Le, 2019, Low dose gamma radiation increases the biomass and ginsenoside content of callus and adventitious root cultures of wild ginseng (Panax ginseng Mayer), Ind Crop Prod, 130, 16, 10.1016/j.indcrop.2018.12.056
Huang, 2010, Selection and optimization of a high-producing tissue culture of Panax ginseng C. A. Meyer, Acta Physiol Plant, 32, 765, 10.1007/s11738-010-0461-6
Kim, 2007, Combined effects of phytohormone, indole-3-butyric acid, and methyl jasmonate on root growth and ginsenoside production in adventitious root cultures of Panax ginseng C.A. Meyer, Biotechnol Lett, 29, 1789, 10.1007/s10529-007-9442-2
Sivakumar, 2006, Enhanced production of bioactive ginsenosides from adventitious roots of Panax ginseng in bioreactor culture, J Hortic Sci Biotechnol, 81, 549, 10.1080/14620316.2006.11512102
Le, 2019, Ginsenoside accumulation profiles in long- and short-term cell suspension and adventitious root cultures in Panax ginseng, Hortic Environ Biotechnol, 60, 125, 10.1007/s13580-018-0108-x
Liang, 2015, Enhancement of ginsenoside biosynthesis and secretion by tween 80 in Panax ginseng hairy roots, Biotechnol Appl Biochem, 62, 193, 10.1002/bab.1256
Huang, 2013, Enhancement of ginsenoside biosynthesis in cell cultures of Panax ginseng by N,N′-dicyclohexylcarbodiimide elicitation, J Biotechnol, 165, 30, 10.1016/j.jbiotec.2013.02.012
Huang, 2013, Elicitation of ginsenoside biosynthesis in cell cultures of Panax ginseng by vanadate, Process Biochem, 48, 1227, 10.1016/j.procbio.2013.05.019
Demidova, 2006, Growth and biosynthetic characteristics of ginseng (Panax japonicus var. repens) deep-tank cell culture in bioreactors, Russ J Plant Physl, 53, 134, 10.1134/S1021443706010171
Kochkin, 2013, Malonyl-ginsenoside content of a cell-suspension culture of Panax japonicus var. repens, Phytochemistry, 93, 18, 10.1016/j.phytochem.2013.03.021
Hu, 2008, Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate, Process Biochem, 43, 113, 10.1016/j.procbio.2007.10.010
Yue, 2008, Manipulation of ginsenoside heterogeneity of Panax notoginseng cells in flask and bioreactor cultivations with addition of phenobarbital, Bioproc Biosyst Eng, 31, 95, 10.1007/s00449-007-0150-z
Wang, 2006, Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate, Appl Microbiol Biotechnol, 70, 298, 10.1007/s00253-005-0089-4
Kochan, 2018, The increase of triterpene saponin production induced by trans-anethole in hairy root cultures of Panax quinquefolium, Molecules, 23, 2674, 10.3390/molecules23102674
Biswas, 2016, Elicitors' influenced differential ginsenoside production and exudation into medium with concurrent Rg3/Rh2 panaxadiol induction in Panax quinquefolius cell suspensions, Appl Microbiol Biotechnol, 100, 4909, 10.1007/s00253-015-7264-z
Wang, 2010, Combination effect of lactoalbumin hydrolysate and methyl jasmonate on ginsenoside and polysaccharide production in Panax quinquefolium L. cells cultures, Acta Physiol Plant, 33, 861, 10.1007/s11738-010-0611-x
Kochan, 2011, Dynamics of ginsenoside biosynthesis in suspension culture of Panax quinquefolium, Acta Physiol Plant, 33, 911, 10.1007/s11738-010-0619-2
Trong, 2017, Biomass accumulation of Panax vietnamensis in cell suspension cultures varies with addition of plant growth regulators and organic additives, Asian Pac J Trop Med, 10, 907, 10.1016/j.apjtm.2017.08.012
Smirnova, 2010, Effect of growth regulators on ginsenoside production in the cell culture of two ginseng species, Russ J Plant Physl, 57, 430, 10.1134/S1021443710030167
Linh, 2019, Improvement of bioactive saponin accumulation in adventitious root cultures of Panax vietnamensis via culture periods and elicitation, Plant Cell Tissue Organ Cult, 137, 101, 10.1007/s11240-018-01555-6
Paddon, 2013, High-level semi-synthetic production of the potent antimalarial artemisinin, Nature, 496, 528, 10.1038/nature12051
Luo, 2019, Complete biosynthesis of cannabinoids and their unnatural analogues in yeast, Nature, 567, 123, 10.1038/s41586-019-0978-9
Li, 2019, Balancing the non-linear rosmarinic acid biosynthetic pathway by modular co-culture engineering, Metab Eng, 54, 1, 10.1016/j.ymben.2019.03.002
Dai, 2014, Producing aglycons of ginsenosides in bakers' yeast, Sci Rep, 4, 3698, 10.1038/srep03698
Dai, 2013, Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides, Metab Eng, 20, 146, 10.1016/j.ymben.2013.10.004
Zhao, 2016, Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae, Biotechnol Bioeng, 113, 1787, 10.1002/bit.25934
Zhao, 2017, Enhancing Saccharomyces cerevisiae reactive oxygen species and ethanol stress tolerance for high-level production of protopanoxadiol, Bioresour Technol, 227, 308, 10.1016/j.biortech.2016.12.061
Zhuang, 2017, Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Metab Eng, 42, 25, 10.1016/j.ymben.2017.04.009
Wang, 2019, Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Cell Discov, 5, 5, 10.1038/s41421-018-0075-5
Hu, 2019, Construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-II glucosides, Green Chem, 21, 3286, 10.1039/C8GC04066D
Liang, 2017, Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis, Metab Eng, 44, 60, 10.1016/j.ymben.2017.07.008
Gutmann, 2014, Towards the synthesis of glycosylated dihydrochalcone natural products using glycosyltransferase-catalysed cascade reactions, Green Chem, 16, 4417, 10.1039/C4GC00960F
Chen, 2018, Synthesis of rebaudioside D, using glycosyltransferase UGTSL2 and in situ UDP-glucose regeneration, Food Chem, 259, 286, 10.1016/j.foodchem.2018.03.126
Dai, 2018, One-pot synthesis of ginsenoside Rh2 and bioactive unnatural ginsenoside by coupling promiscuous glycosyltransferase from Bacillus subtilis 168 to sucrose synthase, J Agric Food Chem, 66, 2830, 10.1021/acs.jafc.8b00597
Eibl, 2018, Plant cell culture technology in the cosmetics and food industries: Current state and future trends, Appl Microbiol Biotechnol, 102, 8661, 10.1007/s00253-018-9279-8