Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

Journal of Psychiatric Research - Tập 34 - Trang 171-181 - 2000
Astrid W Zobel1, Thomas Nickel1, Heike E Künzel1, Nibal Ackl1, Annette Sonntag1, Marcus Ising1, Florian Holsboer1
1Max Planck Institute of Psychiatry, Kraepelinstr. 2–10, D-80804, Munich, Germany

Tài liệu tham khảo

Chalmers, 1996, Corticotropin-releasing factor receptors: from molecular biology to drug design, Trends Pharmacol. Sci., 17, 166, 10.1016/0165-6147(96)81594-X Chen, 1993, Expression cloning of a human corticotropin-releasing factor receptor, Proc. Natl. Acad. Sci. USA, 90, 8967, 10.1073/pnas.90.19.8967 Coplan, 1996, Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders, Proc. Natl. Acad. Sci. USA, 93, 1619, 10.1073/pnas.93.4.1619 Davis, 1992, The role of the amygdala in fear and axiety, Ann. Rev. Neurosci., 15, 353, 10.1146/annurev.ne.15.030192.002033 De Goeij, 1991, Repeated stress-induced activation of corticotropin-releasing factor neurons enhances vasopressin stores and colocalization with corticotropin-releasing factor in the median eminence of rats, Neuroendocrinology, 53, 150, 10.1159/000125712 Gold, 1984, Psychiatric implications of basic and clinical studies with corticotropin-releasing factor, Am. J. Psychiatry, 14, 619 Grigoriadis, 1998, Small molecule CRF1 receptor antagonists: characterization and clinical application, 36 Heinrichs, 1997, Corticotropin-releasing factor CRF1, but not CRF2 receptors mediate anxiogenic-like behavior, Regul. Peptides, 71, 15, 10.1016/S0167-0115(97)01005-7 Holsboer, 1995, Neuroendocrinology of mood disorders, 957 Holsboer, 1999, The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety, J. Psychiat. Res., 33, 181, 10.1016/S0022-3956(98)90056-5 Holsboer, 1996, Antidepressants and HPA regulation, Endocrine Rev., 17, 187, 10.1210/edrv-17-2-187 Holsboer, 1984, Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression, N. Engl. J. Med., 311, 1127, 10.1056/NEJM198410253111718 Holsboer, 1986, Human corticotropin-releasing hormone in depression, Biol. Psychiatry, 21, 601, 10.1016/0006-3223(86)90121-6 Holsboer, 1992, The role of corticotropin-releasing hormone in the pathogenesis of Cushing’s disease, anorexia nervosa, alcoholism, affective disorders and dementia, Prog. Brain Res., 93, 385, 10.1016/S0079-6123(08)64586-0 Kalin, 1985, Biological effects of corticotropin-releasing hormone administered to rhesus monkeys, Fed. Proc., 44, 249 Keck FE, Holsboer F (2000): Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides (In press). Liebsch, 1995, Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats, Regul. Peptides, 59, 220, 10.1016/0167-0115(95)00099-W Liebsch, 1998, Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour, Behav. Brain Res., 94, 301, 10.1016/S0166-4328(97)00198-8 Liebsch, 1999, Differential behavioural effects of chronic infusion of CRH1 and CRH2 receptor antisense oligonucleotides into the rat brain, J. Psychiat. Res., 33, 153, 10.1016/S0022-3956(98)80047-2 Malkoski, 1999, Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene, Mol. Endocrinol., 13, 1629, 10.1210/me.13.10.1629 Nemeroff, 1984, Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients, Science, 226, 1342, 10.1126/science.6334362 Nemeroff, 1988, Reduced corticotropin-releasing factor binding sites in the frontal cortex of suicide victims, Arch. Gen. Psychiatry, 45, 577, 10.1001/archpsyc.1988.01800300075009 Owens, 1991, The physiology and pharmacology of corticotropin-releasing factor, Pharmacol. Rev., 43, 425 Plotsky, 1991, Pathways to the secretion of adrenocorticotropin: a view from the portal, J. Neuroendocrinol., 3, 1, 10.1111/j.1365-2826.1991.tb00231.x Potter, 1994, Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary, Proc. Natl. Acad. Sci. USA, 91, 8777, 10.1073/pnas.91.19.8777 Raadsheer, 1994, Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients, Neuroendocrinology, 60, 433, 10.1159/000126778 Sánchez, 1999, Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain, J. Comp. Neurol., 408, 365, 10.1002/(SICI)1096-9861(19990607)408:3<365::AID-CNE5>3.0.CO;2-N Schulkin, 1998, Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load, Psychoneuroendocrinology, 23, 219, 10.1016/S0306-4530(97)00099-1 Schulz, 1996, CP-154.526: A potent and selective nonpeptide antagonist of corticotropin-releasing factor receptors, Proc. Natl. Acad. Sci. USA, 93, 10477, 10.1073/pnas.93.19.10477 Shaham, 1998, CP-15.526, a selective, nonpeptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroine-trained rats, Psychopharmacology, 137, 184, 10.1007/s002130050608 Skutella, 1994, Antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA reduces anxiety in shuttlebox performance, Neuroreport, 5, 2181, 10.1097/00001756-199410270-00048 Skutella, 1998, Corticotropin-releasing hormone receptor (type 1) antisense targeting reduces anxiety, Neuroscience, 85, 795, 10.1016/S0306-4522(97)00682-9 Smith, 1998, Corticotropin-releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development, Neuron., 20, 1093, 10.1016/S0896-6273(00)80491-2 Steckler, 1999, Corticotropin-releasing hormone receptor subtypes and emotion, Biological Psychiatry, 46, 1480, 10.1016/S0006-3223(99)00170-5 Stenzel-Poore, 1994, Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior, J. Neurosci., 14, 2579, 10.1523/JNEUROSCI.14-05-02579.1994 Swanson, 1989, Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the parventricular nucleus: a hybridization histochemical study in the rat, J. Comp. Neurol., 285, 415, 10.1002/cne.902850402 Timpl, 1998, Impaired stress response and rduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1, Nature Genet., 19, 162, 10.1038/520 Vale, 1981, Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin, Science, 213, 1394, 10.1126/science.6267699 Valentino, 1993, The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses, Ann. NY Acad. Sci., 697, 173, 10.1111/j.1749-6632.1993.tb49931.x Webster, 1996, In vivo and in vitro characterization of antalarmin, a non-peptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation, Endocrinology, 137, 5747, 10.1210/en.137.12.5747 Wotjak, 1996, Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion?, J. Neuroscience, 16, 7725, 10.1523/JNEUROSCI.16-23-07725.1996