Humanised models of infection in the evaluation of anti-malarial drugs

Pearson, 2008, Humanized SCID mouse models for biomedical research, Curr Top Microbiol Immunol, 324, 25, 10.1007/978-3-540-75647-7_2 Sugamura, 1996, The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID, Annu Rev Immunol, 14, 179, 10.1146/annurev.immunol.14.1.179 Hafalla, 2011, Cell biology and immunology of malaria, Immunol Rev, 240, 297, 10.1111/j.1600-065X.2010.00988.x Mercer, 2001, Hepatitis C virus replication in mice with chimeric human livers, Nat Med, 7, 927, 10.1038/90968 Azuma, 2007, Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice, Nat Biotechnol, 25, 903, 10.1038/nbt1326 Bissig, 2007, Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model, Proc Natl Acad Sci U S A, 104, 20507, 10.1073/pnas.0710528105 de Jong, 2010, New horizons for studying human hepatotropic infections, J Clin Invest, 120, 650, 10.1172/JCI42338 Bissig, 2010, Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment, J Clin Invest, 120, 924, 10.1172/JCI40094 Sacci, 1992, Mouse model for exoerythrocytic stages of Plasmodium falciparum malaria parasite, Proc Natl Acad Sci U S A, 89, 3701, 10.1073/pnas.89.9.3701 Sacci, 2002, Gene expression analysis during liver stage development of Plasmodium, Int J Parasitol, 32, 1551, 10.1016/S0020-7519(02)00183-2 Sacci, 2006, Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers, Int J Parasitol, 36, 353, 10.1016/j.ijpara.2005.10.014 Mikolajczak, 2011, Disruption of the Plasmodium falciparum liver stage antigen-1 locus causes a differentiation defect in late liver stage parasites, Cell Microbiol, 13, 1250, 10.1111/j.1462-5822.2011.01617.x Nicoll, 2011, Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase, Malar J, 10, 14, 10.1186/1475-2875-10-14 VanBuskirk, 2009, Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design, Proc Natl Acad Sci U S A, 106, 13004, 10.1073/pnas.0906387106 Morosan, 2006, Liver-stage development of Plasmodium falciparum, in a humanized mouse model, J Infect Dis, 193, 996, 10.1086/500840 Badell, 1995, A mouse model for human malaria erythrocytic stages, Parasitol Today, 11, 235, 10.1016/0169-4758(95)80088-3 Moore, 1995, Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes, J Exp Med, 181, 2265, 10.1084/jem.181.6.2265 Tsuji, 1995, Establishment of a SCID mouse model having circulating human red blood cells and a possible growth of Plasmodium falciparum in the mouse, Vaccine, 13, 1389, 10.1016/0264-410X(95)00081-B Angulo-Barturen, 2008, A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes, PLoS ONE, 3, e2252, 10.1371/journal.pone.0002252 Jiménez-Díaz, 2009, Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes, Antimicrob Agents Chemother, 53, 4533, 10.1128/AAC.00519-09 Arnold, 2011, Further improvements of the P. falciparum humanized mouse model, PLoS ONE, 6, e18045, 10.1371/journal.pone.0018045 Moreno Sabater, 2005, Experimental infection of immunomodulated NOD/LtSz-SCID mice as a new model for Plasmodium falciparum erythrocytic stages, Parasitol Res, 95, 97, 10.1007/s00436-004-1249-7 Moreno, 2001, Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies, Antimicrob Agents Chemother, 45, 1847, 10.1128/AAC.45.6.1847-1853.2001 Moreno, 2006, The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates, Int J Parasitol, 36, 361, 10.1016/j.ijpara.2005.10.012 Moreno, 2007, Plasmodium falciparum-infected mice: more than a tour de force, Trends Parasitol, 23, 254, 10.1016/j.pt.2007.04.004 Badell, 2000, Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium falciparum, J Exp Med, 192, 1653, 10.1084/jem.192.11.1653 Bouharoun-Tayoun, 2004, Plasmodium falciparum: production of human antibodies specific for the MSP-3 protein in the Hu-SPL-SCID mouse, Exp Parasitol, 108, 47, 10.1016/j.exppara.2004.07.004 Druilhe, 2005, A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum, PLoS Med, 2, e344, 10.1371/journal.pmed.0020344 Coterón, 2010, Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series, J Med Chem, 53, 6129, 10.1021/jm100556b Barker, 2011, Aminoindoles: a novel scaffold with potent activity against Plasmodium falciparum, Antimicrob Agents Chemother, 55, 2612, 10.1128/AAC.01714-10 Booker, 2010, Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model, J Biol Chem, 285, 33054, 10.1074/jbc.M110.162081 Coterón, 2011, Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential, J Med Chem, 54, 5540, 10.1021/jm200592f Cosledan, 2008, Selection of a trioxaquine as an antimalarial drug candidate, Proc Natl Acad Sci U S A, 105, 17579, 10.1073/pnas.0804338105 Yipp, 2007, Differential roles of CD36, ICAM-1, and P-selectin in Plasmodium falciparum cytoadherence in vivo, Microcirculation, 14, 593, 10.1080/10739680701404705 Yipp, 2003, Src-family kinase signaling modulates the adhesion of Plasmodium falciparum on human microvascular endothelium under flow, Blood, 101, 2850, 10.1182/blood-2002-09-2841 Yipp, 2003, Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo, Blood, 101, 331, 10.1182/blood-2002-06-1725 Legrand, 2009, Humanized mice for modeling human infectious disease: challenges, progress, and outlook, Cell Host Microbe, 6, 5, 10.1016/j.chom.2009.06.006 Rongvaux, 2011, Human thrombopoietin knock-in mice efficiently support human hematopoiesis in vivo, Proc Natl Acad Sci U S A, 108, 2378, 10.1073/pnas.1019524108 Dorner, 2011, A genetically humanized mouse model for hepatitis C virus infection, Nature, 474, 208, 10.1038/nature10168 Van Duyne, 2009, The utilization of humanized mouse models for the study of human retroviral infections, Retrovirology, 6, 76, 10.1186/1742-4690-6-76