Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis

Akbari, 2007, The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze, Peptides, 28, 650, 10.1016/j.peptides.2006.11.002 Akbari, 2008, The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task, Behav Brain Res, 187, 172, 10.1016/j.bbr.2007.09.019 Aou, 2003, Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats, Neuroscience, 119, 1221, 10.1016/S0306-4522(02)00745-5 Bengzon, 1997, Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures, Proc Natl Acad Sci USA, 94, 10432, 10.1073/pnas.94.19.10432 Casanova, 2013, The effects of early-life seizures on hippocampal dendrite development and later-life learning and memory, Brain Res Bull Chin, 2002, Transforming growth factor beta1 alters synapsin distribution and modulates synaptic depression in Aplysia, J Neurosci, 22, RC220, 10.1523/JNEUROSCI.22-09-j0004.2002 Coras, 2010, Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans, Brain, 133, 3359, 10.1093/brain/awq215 Czubak, 2010, Cognitive effects of GABAergic antiepileptic drugs, Arzneimittelforschung, 60, 1 Deng, 2009, Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain, J Neurosci, 29, 13532, 10.1523/JNEUROSCI.3362-09.2009 Diehl, 1984, Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs, Epilepsia, 25, 506, 10.1111/j.1528-1157.1984.tb03452.x Doreulee, 2010, Orexinergic system and pathophysiology of epilepsy, Georgian Med News, 74 Erken, 2012, Orexins cause epileptic activity, Peptides, 37, 161, 10.1016/j.peptides.2012.06.012 Gray, 1998, Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat, Brain Res, 790, 52, 10.1016/S0006-8993(98)00030-4 Haynes, 1999, Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat, Peptides, 20, 1099, 10.1016/S0196-9781(99)00105-9 Helmstaedter, 2002, Effects of chronic epilepsy on declarative memory systems, Prog Brain Res, 135, 439, 10.1016/S0079-6123(02)35041-6 Huang, 2002, Pentylenetetrazol-induced recurrent seizures in rat pups: time course on spatial learning and long-term effects, Epilepsia, 43, 567, 10.1046/j.1528-1157.2002.29101.x Jaeger, 2002, Effects of orexin-A on memory processing, Peptides, 23, 1683, 10.1016/S0196-9781(02)00110-9 Jessberger, 2009, Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats, Learn Mem, 16, 147, 10.1101/lm.1172609 Jia, 2011, Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats, Neurol Sci, 32, 609, 10.1007/s10072-011-0561-0 Kim, 2010, Angiogenic role of orexin-A via the activation of extracellular signal-regulated kinase in endothelial cells, Biochem Biophys Res Commun, 403, 59, 10.1016/j.bbrc.2010.10.115 Kortunay, 2012, Orexins increase penicillin-induced epileptic activity, Peptides, 34, 419, 10.1016/j.peptides.2012.02.013 Manabe, 1993, Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus, J Neurophysiol, 70, 1451, 10.1152/jn.1993.70.4.1451 Mortazavi, 2005, Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats, Epilepsy Behav, 7, 629, 10.1016/j.yebeh.2005.08.019 Nakagawa, 2000, Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy, Epilepsia, 41, 10, 10.1111/j.1528-1157.2000.tb01498.x Omrani, 2007, Naloxone improves impairment of spatial performance induced by pentylenetetrazol kindling in rats, Neuroscience, 145, 824, 10.1016/j.neuroscience.2006.12.049 Park, 2003, Chronic activation of CREB and p90RSK in human epileptic hippocampus, Exp Mol Med, 35, 365, 10.1038/emm.2003.48 Rejdak, 2009, Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures, Epilepsia, 50, 1641, 10.1111/j.1528-1167.2008.01990.x Rodgers, 2002, Orexins and appetite regulation, Neuropeptides, 36, 303, 10.1016/S0143-4179(02)00085-9 Sakurai, 2005, Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis, Sleep Med Rev, 9, 231, 10.1016/j.smrv.2004.07.007 Scott, 2000, Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures, Exp Neurol, 165, 231, 10.1006/exnr.2000.7458 Selbach, 2010, Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases, Acta Physiol, 198, 277, 10.1111/j.1748-1716.2009.02021.x Selcher, 2003, A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1, Learn Mem, 10, 26, 10.1101/lm.51103 Smialowski, 1980, The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol, Neurosci Lett, 19, 331, 10.1016/0304-3940(80)90283-9 Smith, 2005, Orexin-saporin lesions of the medial septum impair spatial memory, Neuroscience, 132, 261, 10.1016/j.neuroscience.2004.12.037 Soffin, 2002, SB-334867-A antagonises orexin mediated excitation in the locus coeruleus, Neuropharmacology, 42, 127, 10.1016/S0028-3908(01)00156-3 Sutcliffe, 2000, The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding, J Neurosci Res, 62, 161, 10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1 Tang, 2008, The signalling profile of recombinant human orexin-2 receptor, Cell Signal, 20, 1651, 10.1016/j.cellsig.2008.05.010 Telegdy, 2002, The action of orexin A on passive avoidance learning, involvement of transmitters, Regul Pept, 104, 105, 10.1016/S0167-0115(01)00341-X Walling, 2004, Orexin-A infusion in the locus ceruleus triggers norepinephrine (ne) release and ne-induced long-term potentiation in the dentate gyrus, J Neurosci, 24, 7421, 10.1523/JNEUROSCI.1587-04.2004 Wang, 2008, Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats, Brain Res, 1238, 108, 10.1016/j.brainres.2008.07.103 Wu, 2004, Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons, J Neurosci, 24, 3527, 10.1523/JNEUROSCI.5364-03.2004 Xi, 2007, Extracellular signal-regulated protein kinase in human intractable epilepsy, Eur J Neurol, 14, 865, 10.1111/j.1468-1331.2007.01777.x Yang, 2008, Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats, Hippocampus, 18, 460, 10.1002/hipo.20409 Yang, 2013, Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice, J Neurosci, 33, 5275, 10.1523/JNEUROSCI.3200-12.2013 Yokobori, 2011, Stimulatory effect of intracerebroventricular administration of orexin A on food intake in the zebrafish, Danio rerio, Peptides, 32, 1357, 10.1016/j.peptides.2011.05.010