Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway

Neuropharmacology - Tập 63 - Trang 349-361 - 2012
Jiaying Wu1, Zongfu Pan1, Zhiqiang Wang1, Wenjie Zhu1, Yuanyuan Shen2, Rong Cui1, Jiazhen Lin1, Hao Yu1, Qiongque Wang1, Jianchang Qian1, Yongping Yu1, Danyan Zhu1, Yijia Lou1
1Division of Cardio-Cerebral Vascular and Hepatic Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
2Brain Surgery Department, 2nd Affiliated Hospital at School of Medicine, Zhejiang University, China

Tài liệu tham khảo

Antoine, 2011, Evolution of breast cancer incidence in relation to hormone replacement therapy use in Belgium, Climacteric, 14, 464, 10.3109/13697137.2011.561385 Attele, 1999, Ginseng pharmacology: multiple constituents and multiple actions, Biochem. Pharmacol., 58, 1685, 10.1016/S0006-2952(99)00212-9 Bledsoe, 2002, Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition, Cell, 110, 93, 10.1016/S0092-8674(02)00817-6 Boonyaratanakornkit, 2008, The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression, Steroids, 73, 922, 10.1016/j.steroids.2008.01.010 Bourque, 2009, Neuroprotective actions of sex steroids in Parkinson’s disease, Front. Neuroendocrinol., 30, 142, 10.1016/j.yfrne.2009.04.014 Brzozowski, 1997, Molecular basis of agonism and antagonism in the oestrogen receptor, Nature, 389, 753, 10.1038/39645 Castegna, 2003, Proteomic identification of nitrated proteins in Alzheimer’s disease brain, J. Neurochem., 85, 1394, 10.1046/j.1471-4159.2003.01786.x Chan, 2002, Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng, J. Clin. Endocrinol. Metab., 87, 3691, 10.1210/jcem.87.8.8717 Cristina de Assis, 2002, Expression of inducible nitric oxide synthase in human umbilical vein endothelial cells during primary culture, Nitric Oxide, 7, 254, 10.1016/S1089-8603(02)00123-4 Das, 2009, ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice, Am. J. Physiol. Heart Circ. Physiol., 296, H1236, 10.1152/ajpheart.00100.2009 Du, 2011, Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects, J. Immunol., 10.4049/jimmunol.1002579 Du, 2009, Dynamic regulation of mitochondrial function by glucocorticoids, Proc. Natl. Acad. Sci. U.S.A., 106, 3543, 10.1073/pnas.0812671106 Dusek, 2006, The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes, J. Biol. Chem., 281, 3614, 10.1074/jbc.M508258200 German, 2006, Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway, J. Neurochem., 98, 1507, 10.1111/j.1471-4159.2006.04061.x Green, 2000, Estradiol attenuation of beta-amyloid-induced toxicity: a comparison o, J. Neurocytol., 29, 419, 10.1023/A:1007173509470 Heck, 1997, I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor, EMBO J., 16, 4698, 10.1093/emboj/16.15.4698 Hensley, 1994, A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A., 91, 3270, 10.1073/pnas.91.8.3270 Hou, 2009, Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts, J. Cell Physiol., 220, 196, 10.1002/jcp.21751 Janssen-Heininger, 1999, Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants, Am. J. Respir. Cell Mol. Biol., 20, 942, 10.1165/ajrcmb.20.5.3452 Jiang, 1996, Calcium channel blockade and anti-free-radical actions of panaxatriol saponins in cultured myocardiocytes, Zhongguo Yao Li Xue Bao, 17, 138 Jover-Mengual, 2007, MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia, Endocrinology, 148, 1131, 10.1210/en.2006-1137 Kadowaki, 2005, Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation, Cell Death Differ., 12, 19, 10.1038/sj.cdd.4401528 Kalaitzidis, 2005, Transcription factor cross-talk: the estrogen receptor and NF-kappaB, Trends Endocrinol. Metab., 16, 46, 10.1016/j.tem.2005.01.004 Kassel, 2001, Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1, EMBO J., 20, 7108, 10.1093/emboj/20.24.7108 Kimura, 2007, Proapoptotic nitric oxide production in amyloid beta protein-treated cerebral microvascular endothelial cells, Microcirculation, 14, 89, 10.1080/10739680601131127 Kumar, 2009, Dexamethasone ameliorates renal ischemia-reperfusion injury, J. Am. Soc. Nephrol., 20, 2412, 10.1681/ASN.2008080868 Lee, 2008, Hormone effects on specific and global brain functions, J. Physiol. Sci., 58, 213, 10.2170/physiolsci.RV007008 Lee, 1997, Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor, Mol. Cell Endocrinol., 133, 135, 10.1016/S0303-7207(97)00160-3 Leung, 2007, Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity, Neuropharmacology, 52, 827, 10.1016/j.neuropharm.2006.10.001 Li, 2006, Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion, Apoptosis, 11, 923, 10.1007/s10495-006-6305-6 Lo, 2002, Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages, Carcinogenesis, 23, 983, 10.1093/carcin/23.6.983 Ma, 2010, Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury, Neurosci. Lett., 478, 66, 10.1016/j.neulet.2010.04.064 Marchetti, 2005, Glucocorticoid receptor-nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia-neuron interactions, Brain Res. Brain Res. Rev., 48, 302, 10.1016/j.brainresrev.2004.12.030 Marcus, 2003, Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB, Glia, 41, 152, 10.1002/glia.10168 Melcangi, 2009, Neuroactive steroids: an update of their roles in central and peripheral nervous system, Psychoneuroendocrinology, 34, S1, 10.1016/j.psyneuen.2009.11.001 Meltser, 2009, Glucocorticoid receptor and mitogen-activated protein kinase activity after restraint stress and acoustic trauma, J. Neurotrauma, 26, 1835, 10.1089/neu.2008.0874 Mihm, 2001, Free 3-nitrotyrosine causes striatal neurodegeneration in vivo, J. Neurosci., 21, RC149, 10.1523/JNEUROSCI.21-11-j0003.2001 Numakawa, 2007, 17beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium, Endocrinology, 148, 627, 10.1210/en.2006-1210 Reed, 2008, Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule, J. Cell Mol. Med. Ribble, 2005, A simple technique for quantifying apoptosis in 96-well plates, BMC Biotechnol., 5, 12, 10.1186/1472-6750-5-12 Sawe, 2008, Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke, J. Neurosci. Res., 86, 1659, 10.1002/jnr.21604 Shiau, 1998, The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen, Cell, 95, 927, 10.1016/S0092-8674(00)81717-1 Sweatt, 2004, Mitogen-activated protein kinases in synaptic plasticity and memory, Curr. Opin. Neurobiol., 14, 311, 10.1016/j.conb.2004.04.001 Tanenbaum, 1998, Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains, Proc. Natl. Acad. Sci. U.S.A., 95, 5998, 10.1073/pnas.95.11.5998 Tugcu, 2006, Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin, BJU Int., 98, 680, 10.1111/j.1464-410X.2006.06321.x Venkatachalam, 2003, LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites, J. Mol. Graph. Model., 21, 289, 10.1016/S1093-3263(02)00164-X Wang, 2007, Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway, Neuroscience, 145, 911, 10.1016/j.neuroscience.2006.12.059 Wenzel, 2001, Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor, Invest. Ophthalmol. Vis. Sci., 42, 1653 Wollen, 2010, Alzheimer’s disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners, Altern. Med. Rev., 15, 223 Wu, 2010, Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury, Acta Pharmacol. Sin., 31, 1523, 10.1038/aps.2010.186 Xu, 2010, Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells, J. Cell Biochem., 10.1002/jcb.22885 Yamakura, 1998, Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine, J. Biol. Chem., 273, 14085, 10.1074/jbc.273.23.14085 Yamamoto, 2001, Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer, J. Clin. Invest., 107, 135, 10.1172/JCI11914 Zigmond, 2006, Triggering endogenous neuroprotective mechanisms in Parkinson’s disease: studies with a cellular model, J. Neural. Transm. Suppl., 439, 10.1007/978-3-211-45295-0_66