Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Cell - Tập 182 - Trang 1295-1310.e20 - 2020
Tyler N. Starr1, Allison J. Greaney1,2,3, Sarah K. Hilton1,2, Daniel Ellis4,5,6, Katharine H.D. Crawford1,2,3, Adam S. Dingens1, Mary Jane Navarro5, John E. Bowen5, M. Alejandra Tortorici5, Alexandra C. Walls5, Neil P. King4,5, David Veesler5, Jesse D. Bloom1,2,7
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
3Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA
4Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
5Department of Biochemistry, University of Washington, Seattle, WA 98195 USA
6Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195 USA
7Howard Hughes Medical Institute, Seattle, WA 98109 USA

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Cell

Tập 182

1295-1310.e20

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