Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

Neuron - Tập 97 - Trang 1032-1048.e5 - 2018
C.Y. Daniel Lee1,2,3, Anthony Daggett1,2,3, Xiaofeng Gu1,2,3, Lu-Lin Jiang4, Peter Langfelder1, Xiaoguang Li4, Nan Wang1,2,3, Yingjun Zhao4, Chang Sin Park1,2,3, Yonatan Cooper1,2,3, Isabella Ferando5, Istvan Mody3,5,6, Giovanni Coppola1,2,3,5, Huaxi Xu4, X. William Yang1,2,3
1Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
2Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
3Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA
4Neuroscience and Aging Research Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA
5Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
6Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

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