EGFR, KRAS and ROS1 variants coexist in a lung adenocarcinoma patient

Lung Cancer - Tập 95 - Trang 94-97 - 2016
Lixia Ju1, Mingquan Han1, Chao Zhao2, Xuefei Li2
1Department of Integrative Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
2Department of Lung Cancer and Immunology, Tongji University Medical School Cancer Institute, Medical Center, Shanghai, People’s Republic of China

Tài liệu tham khảo

Malvezzi, 2012, European cancer mortality predictions for the year 2012, Ann. Oncol., 23, 1044, 10.1093/annonc/mds024 Cardarella, 2012, The introduction of systematic genomic testing for patients with non-small-cell lung cancer, J. Thorac. Oncol., 7, 1767, 10.1097/JTO.0b013e3182745bcb Ihle, 2012, Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome, J. Natl. Cancer Inst., 104, 228, 10.1093/jnci/djr523 Wen, 2014, Concurrent oncogene mutation profile in Chinese patients with stage Ib lung adenocarcinoma, Medicine (Baltimore), 93, e296, 10.1097/MD.0000000000000296 Fiala, 2013, The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer, Cancer Genet., 206, 26, 10.1016/j.cancergen.2012.12.003 Choughule, 2014, Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer, Br. J. Cancer, 111, 2203, 10.1038/bjc.2014.401 Bergethon, 2012, ROS1 rearrangements define a unique molecular class of lung cancers, J. Clin. Oncol., 30, 863, 10.1200/JCO.2011.35.6345 Rimkunas, 2012, Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion, Clin. Cancer Res., 18, 4449, 10.1158/1078-0432.CCR-11-3351 Takeuchi, 2012, RET,ROS1 and ALK fusions in lung cancer, Nat. Med., 18, 378, 10.1038/nm.2658 Zhu, 2015, Clinicopathologic characteristics of patients with ROS1 fusion gene in non-small cell lung cancer: a meta-analysis, Transl. Lung Cancer Res., 4, 300 Davies, 2012, Identifying and targeting ROS1 gene fusions in non-small cell lung cancer, Clin. Cancer Res., 18, 4570, 10.1158/1078-0432.CCR-12-0550 Shaw, 2015, Crizotinib in ROS1-rearranged non-small-cell lung cancer, N. Engl. J. Med., 372, 683, 10.1056/NEJMc1415359 Takeuchi, 2012, RET, ROS1 and ALK fusions in lung cancer, Nat. Med., 18, 378, 10.1038/nm.2658 Sun, 2010, Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases, J. Clin. Oncol., 28, 4616, 10.1200/JCO.2010.29.6038 Yoshida, 2013, ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases, Am. J. Surg. Pathol., 37, 554, 10.1097/PAS.0b013e3182758fe6 Shaw, 2014, Crizotinib in ROS1-rearranged non-small-cell lung cancer, N. Engl. J. Med., 371, 1963, 10.1056/NEJMoa1406766 Yang, 2014, Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation, Clin. Cancer Res., 20, 1383, 10.1158/1078-0432.CCR-13-0699 Won, 2015, Concomitant ALK translocation and EGFR mutation in lung cancer: a comparison of direct sequencing and sensitive assays and the impact on responsiveness to tyrosine kinase inhibitor, Ann. Oncol., 26, 348, 10.1093/annonc/mdu530 Baldi, 2014, Concomitant EGFR mutation and ALK rearrangement in lung adenocarcinoma is more frequent than expected: report of a case and review of the literature with demonstration of genes alteration into the same tumor cells, Lung Cancer, 86, 291, 10.1016/j.lungcan.2014.09.011 Campos-Gomez, 2015, Lung adenocarcinoma with concurrent KRAS mutation and ALK rearrangement responding to crizotinib: case report, Int. J. Biol. Markers, 30, e254, 10.5301/jbm.5000127 Devarakonda, 2015, Genomic alterations in lung adenocarcinoma, Lancet Oncol., 16, e342, 10.1016/S1470-2045(15)00077-7 Brugger, 2011, Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer, J. Clin. Oncol., 29, 4113, 10.1200/JCO.2010.31.8162 Mao, 2010, KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies, Lung Cancer., 69, 272, 10.1016/j.lungcan.2009.11.020 Linardou, 2008, Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer, Lancet Oncol., 9, 962, 10.1016/S1470-2045(08)70206-7 Benesova, 2010, Multiplicity of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors, Anticancer Res., 30, 1667