Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

British Journal of Nutrition - Tập 108 Số 5 - Trang 801-809 - 2012
Ana Paula Boroni Moreira1, Tatiana Fiche Salles Texeira1, Alessandra Barbosa Ferreira1, Maria do Carmo Gouveia Pelúzio1, Rita de Cássia Gonçalves Alfenas1
1Federal University of Viçosa, Minas Gerais..

Tóm tắt

Lipopolysaccharide (LPS) may play an important role in chronic diseases through the activation of inflammatory responses. The type of diet consumed is of major concern for the prevention and treatment of these diseases. Evidence from animal and human studies has shown that LPS can diffuse from the gut to the circulatory system in response to the intake of high amounts of fat. The method by which LPS move into the circulatory system is either through direct diffusion due to intestinal paracellular permeability or through absorption by enterocytes during chylomicron secretion. Considering the impact of metabolic diseases on public health and the association between these diseases and the levels of LPS in the circulatory system, this review will mainly discuss the current knowledge about high-fat diets and subclinical inflammation. It will also describe the new evidence that correlates gut microbiota, intestinal permeability and alkaline phosphatase activity with increased blood LPS levels and the biological effects of this increase, such as insulin resistance. Although the majority of the studies published so far have assessed the effects of dietary fat, additional studies are necessary to deepen the understanding of how the amount, the quality and the structure of the fat may affect endotoxaemia. The potential of food combinations to reduce the negative effects of fat intake should also be considered in future studies. In these studies, the effects of flavonoids, prebiotics and probiotics on endotoxaemia should be investigated. Thus, it is essential to identify dietetic strategies capable of minimising endotoxaemia and its postprandial inflammatory effects.

Từ khóa


Tài liệu tham khảo

10.1038/msb.2010.46

10.1017/S0007114510003363

10.1258/ebm.2010.009377

10.2337/dc09-1630

10.1172/JCI28898

10.1152/ajpendo.00314.2011

10.1054/clnu.2001.0430

10.1016/j.tox.2007.04.014

10.1017/S0007114510001303

10.1590/S0004-27302008000600006

10.1136/gut.2010.211706

10.1007/s10620-006-9384-x

10.1186/1475-2859-10-S1-S10

10.1111/j.1753-4887.2010.00292.x

10.1161/hc0702.104178

10.1038/nature09922

10.1016/j.beem.2005.07.003

10.1016/j.ecl.2008.06.007

10.2337/dc08-s264

10.1073/pnas.0902380106

10.1097/MCO.0b013e3283478727

10.1152/ajplung.00381.2003

10.1590/S0004-27302009000500017

Moreira, 2012, The influence of endotoxemia on the molecular mechanisms of insulin resistance, Nutr Hosp, 27, 382

10.1016/j.pharmthera.2011.01.012

10.1038/sj.ijo.0802502

10.1093/ajcn.81.2.341

10.2337/dc10-0556

10.1016/j.freeradbiomed.2005.04.026

10.1053/jhep.2003.50116

10.1073/pnas.0804437105

10.1007/s11695-007-9398-2

10.1053/j.gastro.2005.11.046

10.1016/j.femsre.2004.09.003

10.1136/gut.2008.165886

Suzuki, 2010, Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats, Nutr Metab, 12, 7

10.2353/ajpath.2006.060681

10.1111/j.1365-2982.2010.01498.x

10.1097/MCO.0b013e3283476e74

Tso, 1986, Formation and transport of chylomicrons by enterocytes to the lymphatics, Am J Physiol, 250, G715

10.1002/ibd.21403

10.1172/JCI116259

10.4049/jimmunol.170.3.1399

10.1146/annurev.biochem.71.110601.135414

10.1007/s11892-011-0191-1

10.1016/j.phrs.2009.11.001

10.1097/MCO.0b013e328347924a

10.1152/ajpendo.00302.2006

10.1210/jc.2007-0955

10.1023/A:1010377900745

10.1159/000233282

10.1097/01.SLA.0000048450.44868.B1

10.1152/ajpgi.00024.2006

10.1111/j.1365-2796.2010.02270.x

10.1210/er.2009-0030

10.1371/journal.pone.0009085

10.1016/0966-842X(96)10057-3

10.1128/MCB.23.21.7525-7530.2003

10.1007/s00535-005-1747-0

10.2337/dc09-0979

10.1080/13813450902949012

10.1152/ajpgi.00147.2005

10.1073/pnas.0712140105

10.1016/j.it.2003.10.013

10.2337/dc10-0929

10.3109/00365529509096312

10.1093/ajcn/87.5.1219

10.1016/j.chom.2007.10.010

10.1146/annurev.me.27.020176.001015

10.2337/db09-0367

10.1093/jn/138.8.1452

Kvietys, 1991, Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion, Am J Physiol, 261, G384

10.1016/j.metabol.2009.07.009

Sefcíková, 2008, Different functional responsibility of the small intestine to high-fat/high-energy diet determined the expression of obesity-prone and obesity-resistant phenotypes in rats, Physiol Res, 57, 467, 10.33549/physiolres.931117

Schromm, 1998, The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity, J Immunol, 161, 5464, 10.4049/jimmunol.161.10.5464

10.1093/dnares/dsn033

10.2337/db10-1210

10.1182/blood-2006-06-032961

10.2337/dc10-1676

10.3748/wjg.v10.i11.1619

10.1093/jn/132.12.3642

Bastard, 2006, Recent advances in the relationship between obesity, inflammation, and insulin resistance, Eur Cytokine Netw, 17, 4

10.1016/j.bbrc.2006.05.170

10.1016/j.jnutbio.2009.11.011

10.1016/j.atherosclerosis.2008.06.018

Grimaldi, 2009, Proinflammatory signal transduction pathway induced by Shigella flexneri porins in Caco-2 cells, Braz J Microbiol, 40, 701, 10.1590/S1517-83822009000300036

10.1161/hc0902.104353

10.1194/jlr.M800156-JLR200

10.1152/ajpgi.00043.2007

10.2337/db07-1403

10.2337/db06-1491

10.1161/01.STR.0000226901.34927.10

10.1093/ajcn/86.5.1286

10.1016/j.biochi.2010.04.016

10.3945/ajcn.2009.28584

10.1097/01.CCM.0000284586.84952.FB

10.1007/s00125-009-1394-8

10.1074/jbc.M109.044065

10.1152/ajpgi.00098.2010

10.1097/01.ta.0000196574.70614.27

10.1016/S0735-1097(99)00448-9

10.1096/fasebj.8.2.8119492

10.1023/B:DDAS.0000026302.92898.ae

10.1210/jcem.85.10.6914

10.1007/s00125-010-1684-1

10.1016/j.coph.2009.06.016

10.2337/diacare.27.3.813

10.2337/diabetes.52.7.1799

10.1007/s00125-007-0791-0

10.1099/00222615-31-2-73

10.1385/MB:19:3:279

Thông tin
Thông tin xuất bản

British Journal of Nutrition

Tập 108 Số 5

801-809

Thông tin tác giả